Effects of Hot and Cold Foods on Signals of Heart Rate Variability and Nail Fold Microcirculation of Healthy Young Humans: A Pilot Study

Abstract

Down-regulation of microglial activation represents a practical strategy for combating diverse brain disorders such as stroke and neurodegenerative diseases. In the present study, we showed evidence that isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP), a new bioactive metabolite of Danshen (Salvia miltiorrhiza Bunge), exerted an anti-inflammatory effect in lipopolysaccharide (LPS)- induced microglia. Our data showed that IDHP significantly reduced the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in LPS-induced BV-2 cells and rat primary microglia in a dose-dependent manner. IDHP also suppressed mRNA expression of LPSinduced inducible nitric oxide synthase (iNOS), TNF-α and IL-1β. Moreover, IDHP significantly suppressed the production of reactive oxygen species (ROS), nuclear factor κB (NF-κB) translocation and DNA binding activity induced by LPS treatment in BV-2 cells. These findings indicated that IDHP might be of value in the treatment of various microglia-mediated neuroinflammatory diseases.

Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro

“…In general, it is well accepted that NF-κB activation is one of the principal pathways that induce expression of inflammatory molecules in microglia (Wang et al, 2012, Park et al, 2013). Interestingly, increasing evidence suggests the NF-κB pathway as a possible mechanism in which inhibition of autophagy results in attenuation of inflammatory responses (Jiang et al, 2012, Deretic et al, 2013).…”

Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology

“…Several teams of scientists reported its potential physiological basis, by showing that hot-cold medicinal plants may influence differently various parameters: the capillary red blood cell velocity in nail fold microcirculation, pulse characteristics on sphygmogram, hormonal concentrations (serum thyroxin, triiodothyronine, corticosterone, and urine vanillylmandelic acid), metabolic parameters (serum glucose, triglycerides), body weight, enzymatic activities (liver succinate dehydrogenase, liver Na + -K + -ATPase), muscle glycogen, and so on. [334, 339–342]. …”

The low‐FODMAP diet in the management of functional dyspepsia in East and Southeast Asia

“…It is common to use Traditional Chinese Medicine and to add specific ingredients including mushrooms, cumquat peel, and lily bulbs to cure specific health conditions and/or restore balance to the body. [10][11][12][13] In the management of FD, it appears that clinicians in the West and Asia routinely dispense lifestyle and dietary advice, probably in response to the patient's association between food bs_bs_banner and their FD symptoms. 14,15 A study by Miura and colleagues, which surveyed the practices of clinicians involved in the treatment of FD in the Asia-Pacific region, found that between 79% and 95% dispensed lifestyle or dietary advice in the treatment of FD and IBS.…”

“…Cultural beliefs related to healing-provoking or illness-provoking qualities of food are manifest in the pervasive concepts of the "cold" and "heaty" essence of food. [10][11][12][13] Frequently, East and Southeast Asians will attempt to restore balance in their health by brewing tonics and soups including items such as dried ginseng, lily bulbs, and black fungus. Patients may delay their presentation to a clinician (frequently referred to as a Western Medicine Practitioner as opposed to a Chinese Medicine Practitioner) in an attempt to selfheal.…”

“…Patients may delay their presentation to a clinician (frequently referred to as a Western Medicine Practitioner as opposed to a Chinese Medicine Practitioner) in an attempt to selfheal. [10][11][12][13] In terms of societal factors, there is a strong cultural bias in East Asia against the suggestion of mental disorders, and unfortunately, most patients in this region tend to be resistant to a diagnosis of a FGID. In the study by Tan and colleagues, the utilization of an antidepressant to treat FD resulted in large dropouts in part related to the cultural bias against a functional disorder.…”