2001
DOI: 10.1016/s0378-5122(01)00196-7
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Effects of hormonal replacement therapy in postmenopausal hypertensive patients

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Cited by 44 publications
(23 citation statements)
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“…Overall, pooled analysis of randomized placebo-controlled studies indicated that clinic BPs were unchanged whereas 24-hour ambulatory BPs were reduced by 4-5/2-3 mm Hg with transdermal estradiol (Table 2) [19,31,38,[64][65][66][67][68][69][70]. This reduction in ambulatory BP was seen in both normotensive [31,38,69] and hypertensive women [66].…”
Section: Effects Of Estrogen On Blood Pressure In Postmenopausal Womenmentioning
confidence: 96%
“…Overall, pooled analysis of randomized placebo-controlled studies indicated that clinic BPs were unchanged whereas 24-hour ambulatory BPs were reduced by 4-5/2-3 mm Hg with transdermal estradiol (Table 2) [19,31,38,[64][65][66][67][68][69][70]. This reduction in ambulatory BP was seen in both normotensive [31,38,69] and hypertensive women [66].…”
Section: Effects Of Estrogen On Blood Pressure In Postmenopausal Womenmentioning
confidence: 96%
“…Combined with transdermal NETA, none of the five studies found a significant change. Combined with an oral progestogen, 11 of the 14 studies did not find a significant effect, 3 studies found decreases up to 9% to be significant from baseline (74,78) or compared with placebo (66,74,78). Among the two studies using intranasal HT, one using unopposed intranasal E 2 (97) found nonsignificant changes and one study using intranasal E 2 plus oral dydrogesterone (101) found a slight but significant increase from baseline.…”
Section: Fertility and Sterility âmentioning
confidence: 99%
“…Among these, five studies included women with CHD (31,32,36,84,95), 12 included women with established risk factors (diabetes, impaired glucose tolerance, or metabolic syndrome in 5 studies) (34,53,55,75,81), hypertension in 3 studies (45,74,78), and (mild) hypercholesterolemia in 4 studies (29,67,85,89), one included women who had undergone a hysterectomy for cervical cancer (27) and the other 52 studies included healthy postmenopausal women (including women hysterectomized for benign reasons).…”
Section: Study Characteristicsmentioning
confidence: 99%
“…The selection of a specific antihypertensive drug in these patients should be grounded on the results of trials specifically aimed at hypertension in the older woman, taking into consideration aspects of safety and tolerability. There is increasing evidence that ACE inhibitors seem to be the medications of first choice in this population, not just because they are effective, but also because they do not cause further deterioration in the parameters of the menopausal metabolic syndrome, and since they may act in synergy with estrogen replacement therapy [31,49].…”
Section: Discussionmentioning
confidence: 99%
“…Early studies reported that menopausal women using hormone replacement therapy have lower blood pressures than controls [29,30]. In a more recent report, Affinito et al [31] found that hormone replacement therapy brought a significant reduction of blood pressure values as shown by ambulatory monitoring. Blood pressure decreased in both estrogenic and progestinic phases, and the decrease was particularly evident in daytime measurements.…”
Section: Estrogen Replacement Therapy and Hypertensionmentioning
confidence: 99%