Effects of homoeopathic ultrahigh dilutions of Aconitum napellus on Baker's yeast-induced fever in rabbits

Ahmad, Saeed; Rehman, Tayyeba; Abbasi, Waheed Mumtaz

doi:10.1016/s2095-4964(17)60329-7

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…It has action on a specific cyclooxygenase (COX) isoenzyme in the CNS [43] . Results are in accordance with other study results [28] , [39] , [44] .…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, administration of baker's yeast in rabbits caused significant elevation of temperature in 4 h. Our results matched to earlier studies reporting fever induced by baker's yeast in rats and rabbits [26] , [30] , [39] . In the classical model of fever pathogenesis, the release of pyrogenic cytokines such as interleukin IL-1, IL-6, TNF-α and interferons into the blood, induced fever [40] .…”

Section: Discussionsupporting

confidence: 92%

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In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

Ahmad

Rehman

Abbasi

2018

Journal of Ayurveda and Integrative Medicine

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BackgroundHomeopathy is a controversial alternative system of medicine. The action of homeopathic medicines is considered slow and it is assumed that homeopathic medicines are ineffective in acute conditions such as fever.ObjectiveIn the present study, effects of 3 homeopathic medicines on baker's yeast induced fever were investigated.Materials and methods42 local strain rabbits were equally divided into 7 groups. Normal saline was orally administered to group 1 (normal control) rabbits without fever induction. Group 2 underwent baker's yeast-induced fever (negative control). Groups 3, 4, 5, 6 and 7 underwent baker's yeast-induced fever and were thereafter treated orally with paracetamol, Nux vomica 200C and 1M, Calcarea phos 200C and Belladonna 200C respectively. Rectal temperature was checked hourly. The abdominal writhing and frequency of loose stools were also monitored. ANOVA was applied for checking statistical significance. p ≤ 0.05 was considered significant.ResultsThe rectal temperature increased significantly (p < 0.05) in the negative control group when compared to the normal control. Abdominal writhing and loose stools monitoring showed increased writhing and loose stools frequency of group 2, 3, 6 and 7 rabbits. However, treatment of paracetamol significantly reduced rectal temperature. Group 4 & 5 showed significant reduction of rectal temperature together with abatement of abdominal writhing and loose stools.ConclusionN. vomica ultra-high dilutions have normalized rectal temperature and prevented the abdominal writhing and loose stools in baker's yeast-induced fever model of rabbits. It could be due to antidotal activity of N. vomica ultra-high dilutions. Therefore, N. vomica ultra-high dilutions can be useful antipyretic agents and can treat conditions associated with gastrointestinal symptoms. However, fixed conclusion can't be asserted due to caveat of small sample size.

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“…It has action on a specific cyclooxygenase (COX) isoenzyme in the CNS [43] . Results are in accordance with other study results [28] , [39] , [44] .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

Ahmad

Rehman

Abbasi

2018

Journal of Ayurveda and Integrative Medicine

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“…Our study results are matching to other studies that have also shown reduction of temperature in rabbits by paracetamol at same dose. 10 , 16 Antipyretics and non-steroidal anti-inflammatory drugs (NSAIDS) reduce temperature by inflammation reduction in the peripheral and CNS thermoregulatory sites. 17…”

Section: Discussionmentioning

confidence: 99%

Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of hydro-methanolic extract of Cleome scaposa leaves

Abbasi

Ahmad

Perveen

et al. 2018

Journal of Traditional and Complementary Medicine

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Cleome scaposa has been associated with the prevention of many diseases as fever, abdominal complaints and cancer. But its antipyretic effect is not reported so far. The aim of this study was to assess the efficacy of C. scaposa in reducing temperature in Baker's yeast-induced fever model of rabbits. Rabbits were randomized into 4 groups (n = 24). Fever was induced in by Saccharomyces cerevisae (3 mL/kg of 10% suspension subcutaneous) in all study groups. Afterward, group 1, 2, 3 and 4 were orally administered with paracetamol 150 mg/kg b. wt., distilled water, C. scaposa 250 and 500 mg/kg b. wt. respectively. 500 mg/kg dosage was selected after dose fixation study. The standard control was paracetamol. Rectal temperature was recorded with the help of a digital thermometer. ANOVA followed by post hoc test was applied for statistical analysis of results. Results of the study indicate that C. scaposa possesses antipyretic activity comparable to that of standard drug paracetamol as it exhibited comparable antipyretic potential against baker's yeast-induced fever in rabbits. This study confirms the traditional use of C. scaposa in fever. So, it can be an alternative therapeutic choice in fever. However, specific constituents responsible for its antipyretic activity should be evaluated.

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“…However, fever should be controlled with immediate attention as it could result in serious consequences [10,11] . Several complimentary therapies like Homeopathy can also control fever when applied according to its philosophy and principles [12][13][14] .…”

Section: Treatment Of Fevermentioning

confidence: 99%

Thermoregulation and fever: A brief review

Ahmad¹,

Rehman²

2018

Int. J. Homoeopathic Sci.

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Thermoregulation is a homeostatic mechanism that maintains the body temperature at a prime level. Fever is produced when thermoregulation is not attained due to some reasons and is characterized by elevated body temperature above the normal range, associated with increased pulse, aches, chills, tissue destructions, restlessness and other symptoms. When infectious stimuli meet the body, it increases proinflammatory cytokines and consequently increased production of prostaglandins that in turn stimulate hypothalamus to raise body temperature. Treatment of fever is done mainly by antipyretic drugs that could have control fever efficiently however have serious side effects. So, attempts are made to find alternative medical fields that could treat fever with least side effects.

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Effects of homoeopathic ultrahigh dilutions of Aconitum napellus on Baker's yeast-induced fever in rabbits

Cited by 12 publications

References 24 publications

In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle

Preliminary phytochemical analysis and in vivo evaluation of antipyretic effects of hydro-methanolic extract of Cleome scaposa leaves

Thermoregulation and fever: A brief review

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