Effects of homeopathic medications Eupatorium perfoliatum and Arsenicum album on parasitemia of Plasmodium berghei-infected mice

Lira-Salazar, Guadalupe; Marines-Montiel, E.; Torres-Monzón, Jorge Aurelio; Hernández-Hernández, Fidel de la Cruz; Salas-Benito, Juan Santiago

doi:10.1016/j.homp.2006.06.003

Cited by 26 publications

(25 citation statements)

References 30 publications

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“…An alkaline-soluble polysaccharide fraction was shown to exhibit immunostimulating activities under in vitro conditions [14,15,16]. Furthermore, investigations concerning antiinflammatory [17, 18], cytotoxic and antibacterial [19] as well as antiprotozoal [20] activities have been carried out. The few clinical studies dealing with different preparations of E. perfoliatum only partly support the phytotherapeutic indications [21,22,23].…”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Derivatives from Eupatorium perfoliatum L.

2008

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From the ethyl acetate soluble fraction of a methanol/water extract of the herb Eupatorium perfoliatum L. (Asteraceae) six caffeic acid derivatives have been isolated and identified by 1D- and 2D-NMR spectroscopic data. Besides the common quinic acid derivatives 5-caffeoylquinic acid (chlorogenic acid), 3-caffeoylquinic acid (neochlorogenic acid) and 3,5-dicaffeoylquinic acid, three up to now unknown depsides of caffeic acid with glucaric acid have been isolated: 2,5-dicaffeoylglucaric acid, 3,4-dicaffeoylglucaric acid, and 2,4- or 3,5-dicaffeoylglucaric acid.

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Section: Introductionmentioning

confidence: 99%

Caffeic Acid Derivatives from Eupatorium perfoliatum L.

2008

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“…Consistent with this claim, animal studies demonstrate an ability of homeopathic Eupatorium perfoliatum or Arsenicum album to inhibit Plasmodium parasite multiplication [178]. Combinations of other common homeopathic remedies in mice (i.e., Bryonia alba, Thuja occidentalis, Aconitum napellus, Arsenicum album, and Lachesis ) can inhibit experimental infection with Leishmania amazonensis [179], as can other types of nanoparticles [49, 180–182].…”

Section: Resultsmentioning

confidence: 96%

Advances in integrative nanomedicine for improving infectious disease treatment in public health

Bell

Schwartz

Boyer³

et al. 2013

European Journal of Integrative Medicine

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Introduction Infectious diseases present public health challenges worldwide. An emerging integrative approach to treating infectious diseases is using nanoparticle (NP) forms of traditional and alternative medicines. Advantages of nanomedicine delivery methods include better disease targeting, especially for intracellular pathogens, ability to cross membranes and enter cells, longer duration drug action, reduced side effects, and cost savings from lower doses. Methods We searched Pubmed articles in English with keywords related to nanoparticles and nanomedicine. Nanotechnology terms were also combined with keywords for drug delivery, infectious diseases, herbs, antioxidants, homeopathy, and adaptation. Results NPs are very small forms of material substances, measuring 1–100 nanometers along at least one dimension. Compared with bulk forms, NPs’ large ratio of surface-area-to-volume confers increased reactivity and adsorptive capacity, with unique electromagnetic, chemical, biological, and quantum properties. Nanotechnology uses natural botanical agents for green manufacturing of less toxic NPs. Discussion Nanoparticle herbs and nutriceuticals can treat infections via improved bioavailability and antiinflammatory, antioxidant, and immunomodulatory effects. Recent studies demonstrate that homeopathic medicines may contain source and/or silica nanoparticles because of their traditional manufacturing processes. Homeopathy, as a form of nanomedicine, has a promising history of treating epidemic infectious diseases, including malaria, leptospirosis and HIV/AIDS, in addition to acute upper respiratory infections. Adaptive changes in the host’s complex networks underlie effects. Conclusions Nanomedicine is integrative, blending modern technology with natural products to reduce toxicity and support immune function. Nanomedicine using traditional agents from alternative systems of medicine can facilitate progress in integrative public health approaches to infectious diseases.

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“…3 In previous studies, the effect of homeopathic medicines in parasitic diseases has shown good results regarding the clinical evolution of experimental infections in mice. This could be seen in Plasmodium bergei, 4 Trypanosoma cruzi 5,6 and Leishmania amazonensis 7 experimental infection. Considering the natural infection treatment, just one case of a dog infected with Leishmania (L.) amazonensis and treated with Zincum iodatum was found in the literature.…”

Section: Introductionmentioning

confidence: 94%