Effects of HMG-CoA reductase inhibitors on continuous post-inflammatory vascular remodeling late after Kawasaki disease

Abstract

The results of this study suggested that HMG-CoA reductase inhibitors are useful as an alternative therapeutic strategy for stabilizing continuous post-inflammatory vascular remodeling that results in the development of arteriosclerosis late after KD or early onset of atherosclerosis in the future.

Pediatric Interventions Using Noninvasive Vascular Health Indices

“…56 Two of these interventions reported significant improvement in FMD (∆ in FMD, +1.58 to +3.8%; P<0.05) and PWV (1027.2±166.4 versus 1175.4±277.3 cm/s; P=0.001). 44,55 Furthermore, in these studies, statin treatment resulted in significant total cholesterol reduction (∆ in mean total cholesterol, −0.6993 to −2.16 mmol/L; P<0.0001). 45,55 Earlier initiation of statin treatment for subjects with familial hypercholesterolemia was associated with significantly thinner CIMT values compared with later initiation (P=0.016).…”

“…44,55 Furthermore, in these studies, statin treatment resulted in significant total cholesterol reduction (∆ in mean total cholesterol, −0.6993 to −2.16 mmol/L; P<0.0001). 45,55 Earlier initiation of statin treatment for subjects with familial hypercholesterolemia was associated with significantly thinner CIMT values compared with later initiation (P=0.016). 44 Two nonstatin drug interventions targeted obese subjects with nondiabetic/nonhormonal obesity and polycystic ovary syndrome.…”

“…21 Carotid IMT (CIMT) is a significant predictor of stroke and myocardial infarction in adults. 22 Children with hypertension, obesity, and familial hypercholesterolemia demonstrate higher IMT values than healthy children. [23][24][25] Increased IMT values in the femoral artery are also considered a cardiovascular risk factor, although the femoral IMT is studied less frequently than CIMT.…”

“…44,45,55,56 Statin treatments were tested on adolescents and children with familial hypercholesterolemia, 44,45 Kawasaki disease, 55 and obesity. 56 Two of these interventions reported significant improvement in FMD (∆ in FMD, +1.58 to +3.8%; P<0.05) and PWV (1027.2±166.4 versus 1175.4±277.3 cm/s; P=0.001).…”

Premature Atherosclerosis Long After Kawasaki Disease

“…This experimental result suggests that post arteritis tissue may more easily develop atherosclerosis. Intriguingly, they also demonstrated the anti-inflammatory activities of HMG-CoA reductase inhibitors against the progress of acute arteritis (Hamaoka et al, 2010).…”