Effects of high- vs moderate-intensity exercise on natural killer cell activity

Nieman, David C.; Miller, Amanda J.; Henson, Dru A.; Warren, Beverly J.; Gusewitch, G.; Johnson, Robert; Davis, James H.; Butterworth, D. E.; Nehlsen-Cannarella, Sandra L.

doi:10.1249/00005768-199310000-00008

Cited by 128 publications

(102 citation statements)

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“…Aerobic activity in Karacabey study was 30 minutes running on treadmill with intensity 60 to 70 percent of maximal oxygen uptake that is very similar to the present study in terms of intensity and duration [18]. Factors like type, duration, intensity, and program of the exercise and the use of different subjects, various complex mechanisms including hormonal, metabolic and psychoneural stress are also known to have effects on the immune system and discrepancy between this study and other studies [32]. According to the conducted studies, it has been determined that body activities are one of the effective factors in changing of immune system process, which depends on the intensity, time, training plan, and body athleticism.…”

Section: Discussionsupporting

confidence: 72%

“…As seen in study of Gleeson et al (2007), missing one night of sleep is not uncommon amongst athletes travelling across time zones, recreational athletes with nocturnal work habits and military personnel during training and operations [9]. Several factors such as type, duration, intensity, and program of exercise have also important effects on immune response to exercise [32]. showed that aerobic exercise led to changes in immunoglobulin's associated to elevated level of cortisol hormone level [18].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Sleep Deprivation on Serum Igg Responses to Aerobic Activity in College Student Athletes

Saeed

Mirza

2014

PES

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Background & Aims: Sleep is a restorative process for the immune system. There are many situations in which sleep is disturbed prior to an athletic event. However, the effect of sleep deprivation on immune indices in response to exercise remains unknown. The aim of this study was to investigate the effects of sleep deprivation on serum IgG responses to aerobic activity. Materials & Methods: In this quasi-experimental study, 10 male physical education students were voluntarily participated. Study was performed in two separate occasions; control and experimental within two weeks. In the control occasion, normal sleep and aerobic activity and in the experimental occasion, sleep deprivation and aerobic activity was applied. Aerobic activity was performed on bicycle ergometer for 30 minutes at intensity of 70 to 75 percent of maximum heart rate. Changes in serum IgG concentrations in pre-test, before and after aerobic activity in both occasions were analyzed by the two repeated measures ANOVA and dependent T-test using SPSS software. Results: The results showed that sleep deprivation not significantly effect on Serum IgG response to aerobic activity (p=0.130). Also, aerobic activity not significantly effect on Serum IgG concentration (p=0.357). But sleep deprivation caused a significantly increase in serum IgG concentration (p=0.035). Conclusion: No significant effect of sleep deprivation on serum IgG concentrations response to aerobic activity.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

The Effect of Sleep Deprivation on Serum Igg Responses to Aerobic Activity in College Student Athletes

Saeed

Mirza

2014

PES

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“…4). Some reports suggested that the NK cells activity on a per NK cells basis is unchanged during exercise (Nieman et al, 1993;Palmo et al, 1995) or reduced (Ostrowski et al, 1998b) depending on exercise intensity. These results also a consistent finding in this study and supplementation of EBE in exercise group significantly increased NK cells activity.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of Eisenia bicyclis on Innate Immune Cells in Acute Exercise-Stress Rat Model

Namkoong¹,

Cheoung²,

Joo³

et al. 2011

Korean Journal of Plant Resources

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-In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis on innate immune cells to evaluate the possibilities as an immunomoulator in exercise stress. Twenty male SD rats were divided into four groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) (200 mg/kg) intake and maintained at rest ; B, no EBE intake and undergoing exercise ; C, EBE intake and undergoing exercise ; D, EBE intake and maintained at rest. After 5 weeks of oral supplementation, rats were undergoing intensive swimming exercises for 2 h and sacrificed to assess the effects on peritoneal macrophages, spleen cells and natural killer (NK) cells. We showed increasing effects on nitric oxide-inducible nitric oxide synthase (NO-iNOS) production by macrophages and no effects of NK tumoricidal activity and suppressive effects on spleen cell proliferation in exercise group. However, EBE supplementation suppressed NO-iNOS production by macrophages and increased NK tumoricidal activity and spleen cell proliferative response to mitogen in exercise group. Overall, these results that EBE supplementation has differential effects on innate immune response and could be useful as sports nutrition.

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“…In fact, Baslund et al [23] showed a good effect of 8 wks of bicycle training on the immune system of patients with rheumatoid arthritis, although they pointed out that it would need to be clearly established whether benefit occurs through direct modulation of cell counts and cytokines, or through changes in the activity of transcription factors for pro-inflammatory cytokines. In general, increased levels of T and B lymphocyte subclasses have been found during acute exercise [14,24,25], while controversial data have been obtained in the activity of NK cells since they have been found to increase during exercise [26], subsequently decreasing at the end of the effort [27], remain unchanged [28,29], or be reduced [30]. A metaanalysis of 94 studies evaluating NK cell counts showed that there is a marked increase at the end of exercise, and a catecholamin-mediated demargination of cells has been considered as being responsible for this occurrence [31].…”

Section: Generalitiesmentioning

confidence: 99%

Natural killer cells responsiveness to physical exercise: A brief review

Crisafulli¹,

Tocco²,

Melis³

et al. 2013

OJI

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Natural killer cells (NK) are a group of peripheral blood lymphocytes which display cytotoxic activity against a wide range of tumour cells. They are a consistent part of the inflammatory response that is activated when either internal or external injuries occur as they are able to synthesize perforins. An important role is played by NK cells in the host defence against tumours without expressing any antigen-binding recaptor in their membrane which, however, distinguish T and B lymphocytes. NK activity appears early in the immune response, thus providing immediate protection during the time required for the activation and proliferation of cytotoxic T lymphocytes and for their differentiation into functional cells. Even though much research regarding the effects of aerobic training exercise on NK cell numbers and function, there appears to be much controversy regarding its effect. NK cells are rapidly mobilized into circulation in response to acute exercise, most likely by increased shear stress and catecholamine-induced down-regulation of adhesion molecule expression. However, tissue injury and inflammation which often accompanies strenuous exercise have been associated to post-exercise NK cell suppression. Scientific evidence indicates exercise-induced changes in NK cell redistribution and function should be strongly influenced by stress hormones including catecholamines, cortisol and prolactin as well as by soluble mediators such as cytokines and prostaglandins. The role of exercise therapy in cancer patients and survivors rehabilitation is becoming increasingly important as it is thought to modulate immunity and inflammation. However, more knowledge about the effects of exercise on immune function in these patients is needed.

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Effects of high- vs moderate-intensity exercise on natural killer cell activity

Cited by 128 publications

References 0 publications

The Effect of Sleep Deprivation on Serum Igg Responses to Aerobic Activity in College Student Athletes

The Effect of Sleep Deprivation on Serum Igg Responses to Aerobic Activity in College Student Athletes

Immunomodulatory Effects of Eisenia bicyclis on Innate Immune Cells in Acute Exercise-Stress Rat Model

Natural killer cells responsiveness to physical exercise: A brief review

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