Effects of high-tryptophan diet on pre- and postnatal development in rats: a morphological study

Castrogiovanni, Paola; Musumeci, Giuseppe; Trovato, Francesca M.; Avola, Rosanna; Magro, Gaetano; Imbesi, Rosa

doi:10.1007/s00394-013-0528-4

Cited by 41 publications

(21 citation statements)

References 39 publications

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“…Even the excess of L-Tp in diet of pregnant rats, showed adverse effects on their descendants [25], in particular on muscle tissue development. Indeed, this amino acid has been shown to limit the production of IGF-I by the liver [26], therefore, we could hypothesize the existence of a real 5HT/growth hormone (GH)/IGF-I axis [27]. In humans, there are numerous clinical observations in pregnancy, which may confirm these experimental conclusions.…”

Section: Endocrine and Paracrine Factorssupporting

confidence: 68%

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

Musumeci¹,

Castrogiovanni²,

Trovato³

et al. 2015

J Histol Histopathol

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The purpose of this brief narrative review is to highlight the role of nutrition during the gestation period. We focused on the possible effects of imbalance of some nutrients in normal course of pregnancy and embryonic development. We discussed about changes in nutritional and/or hormonal embryonic microenvironment, which represent the basis of a phenomenon known as "fetal programming". We strongly believe that the understanding of these events can be a valuable tool in order to prevent the onset of disorders and diseases in postnatal life.

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Section: Endocrine and Paracrine Factorssupporting

confidence: 68%

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

Musumeci¹,

Castrogiovanni²,

Trovato³

et al. 2015

J Histol Histopathol

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“…In this hypothesis, the inhibited development of 5HT neurons and the anatomic and functional alterations of the brain could lead to a lower production of pituitary GH, that will mean lower hepatic IGF-I production with related consequences on development and growth (Figure 2). In the CNS, the excess of 5HT prevents the normal differentiation of serotonergic neurons of the raphe nuclei with Our recent study 37 also supports the negative effects of hyperserotonemia on pre-and post-natal development. An excess intake of l-Trp in maternal diet may result in dysregulation of the peripheral 5HT homeostasis, leading to high concentrations of 5HT in blood.…”

Section: Gh/igfssupporting

confidence: 82%

“…IGFs are detectable in many foetal tissues since the first trimester of pregnancy and their concentrations in foetal circulation increases during all pregnancy. Though IGFs are not necessary for survival, their lack has consequences on muscular and osteoblastic tissue differentiation that is on body growth 37 .…”

Section: Gh/igfsmentioning

confidence: 99%

Serotonin/growth hormone/insulin-like growth factors axis on pre- and post-natal development: A contemporary review

Musumeci¹,

Trovato²,

Avola³

et al. 2013

OA Anatomy

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Introduction l-tryptophan is the precursor of serotonin. Serotonin regulates the secretion of pituitary growth hormonewhich in turn stimulates production of insulin-like growth factors (IGFs). IGFs are necessary for development and growth.We reviewed the most recent literature regarding the role of serotonin/growth hormone/IGF-I axis on development and growth. The link between serotonin, growth hormone and IGF production is widely reported in the literature. Many studies demonstrate impaired growth and development in off spring of pregnant rats with low levels of plasmatic serotonin. The most recent literature shows the possible negative influence of serotonin in excess on differentiation of serotonergic neurons with consequent reduction in pituitary growth hormone production, which has a direct effect on hepatic production of IGF-I, particularly in the post-natal period. Recent literature also shows that hyperserotonemia in pregnant rats causes disorders in offspring, such as lower body mass and a lower survival rate. In addition, data show that high serotonin levels could inhibit development of serotonin neurons and lead to

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“…These molecules are considered the most potent regulators of cell proliferation, apoptosis, oogenesis, embryogenesis, and ovarian secretion [17]. During intrauterine life, IGFs play an important role in regulating the nutrient metabolism (the later stages of gestation), while in the immediately neonatal period, they promote and control the use of energy for growth and for the definitive differentiation of tissues, such as musculoskeletal and nervous ones, and the progressive adaptation to the extrauterine environment [18]. IGFs perform essential functions, such as increasing protein synthesis and, at the same time, limiting their catabolism.…”

Section: Developmental Origins Of Health and Disease (Dohad)mentioning

confidence: 99%

The Role of Malnutrition during Pregnancy and Its Effects on Brain and Skeletal Muscle Postnatal Development

Castrogiovanni

Imbesi

2017

JFMK

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"Foetal programming" refers to nutritional and hormonal variations during pregnancy. A maternal proper diet has a fundamental role in decreasing pregnancy complications and to prevent possible diseases in postnatal life. In our narrative review, we analyze and discuss the role of malnutrition during pregnancy and its effects on pre-and postnatal development of embryos. Our review proposes a comprehensive and careful analysis of the studies in this field regarding malnutrition and foetal programming. Evidence shows that nutrient imbalance before implantation may result in somatic hypoevolutism at birth, and endocrine and metabolic dysfunctions in postnatal life. In addition, the maternal malnutrition could exert a suppressive effect on the maternal and foetal immune response. It could also affect both the proliferation of myogenic precursors reducing the number of muscle fibres and the future reproductive maturation with possible consequent impaired fertility and quality of gametes. In conclusion, it is necessary to develop dietary strategies to optimize nutrition, not only during pregnancy but already when it is programmed, in order to improve the outcomes of pregnancy, promote growth, healthy child development, reduce the risk of chronic diseases, and slow down the metabolic decline associated with aging.

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Effects of high-tryptophan diet on pre- and postnatal development in rats: a morphological study

Cited by 41 publications

References 39 publications

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

Serotonin/growth hormone/insulin-like growth factors axis on pre- and post-natal development: A contemporary review

The Role of Malnutrition during Pregnancy and Its Effects on Brain and Skeletal Muscle Postnatal Development

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