Effects of high levels of Brussels sprouts in the diet of rats

Groot, A. P. De; Willems, M.I.; Vos, Rudi H. De

doi:10.1016/0278-6915(91)90110-s

Cited by 31 publications

(10 citation statements)

References 32 publications

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“…An old animal study shows that intake of large amount of brussels sprouts, which contains highest amount of goitrin among brassica vegetables, suppresses thyroid function in rats. ( 26 ) However, a clinical trial conducted later showed that daily consumption of 150 g of brussels sprouts for 4 weeks did not impair thyroid function in humans. ( 27 ) A recent report have estimated that daily intake of 100 g brassica vegetables does not increase the plasma goitrin level to impair thyroid functions in humans.…”

Section: Discussionmentioning

confidence: 99%

Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects

Yanaka

2018

J. Clin. Biochem. Nutr.

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Chronic oxidative stress impairs regular defecation. Sulforaphane (SFN) enhances anti-oxidant systems, ameliorating oxidative injury. SFN inhibits overgrowth of anaerobic microflora and protects small intestine from oxidative injury. We assessed whether daily intake of SFN-rich broccoli sprouts (BS) improves defecation in humans. Forty-eight subjects, with a constipation scoring system (CSS) >2 points, were assigned to either the BS group (n = 24) or the alfalfa sprouts (AS) group (n = 24), and were requested to eat 20 g daily of raw BS or AS, respectively, for 4 weeks. BS contains 4.4 mg/g sulforaphane glucosinolates (SGS), while AS contains no SGS. CSS-based questionnaires were performed to evaluate bowel habit. Stool samples were collected to evaluate intestinal microflora using a terminal restriction fragment length polymorphism flora analysis. Intervention with BS, but not AS, caused a significant decrease in the duration of attempted defecation and the total CSS score. Intervention with BS decreased the percentage of Bifidobacterium in the stool. These results suggest that daily intake of BS improves bowel habit in human subjects. Since BS treatment enhance antioxidant enzyme activities, these effects of BS appear to relate with the SFN-mediated modulation of the intestinal motility during exposure to oxidative stress. (UMIN Clinical Trial Registration Number: UMIN-000021207)

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Section: Discussionmentioning

confidence: 99%

Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects

Yanaka

2018

J. Clin. Biochem. Nutr.

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“…When glucosinolate values were expressed as mmol/100 g, the average molecular weight of glucosinolates as reported in the study was used in the conversion to mg/100 g based on the appropriate equation (mol ¼ mass/molecular weight). If the study did not report a molecular weight, it was excluded from the database (Carlson et al 1981;Tiedink et al 1988;De Groot et al 1991;Shattuck et al 1991;Rosa & Heaney, 1993;Shattuck & Wang, 1994;Hansen et al 1997;Kushad et al 1999;Rodrigues & Rosa, 1999). Data expressed as mg/kg and parts per million were also converted to mg/100 g (Daxenbichler et al 1979;Lewis & Fenwick, 1988).…”

Section: Methodsmentioning

confidence: 99%

Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables

2003

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Evidence indicates that cruciferous vegetables are protective against a range of cancers with glucosinolates and their breakdown products considered the biologically active constituents. To date, epidemiological studies have not investigated the intakes of these constituents due to a lack of food composition databases. The aim of the present study was to develop a database for the glucosinolate content of cruciferous vegetables that can be used to quantify dietary exposure for use in epidemiological studies of diet -disease relationships. Published food composition data sources for the glucosinolate content of cruciferous vegetables were identified and assessed for data quality using established criteria. Adequate data for the total glucosinolate content were available from eighteen published studies providing 140 estimates for forty-two items. The highest glucosinolate values were for cress (389 mg/100 g) while the lowest values were for Pe-tsai chinese cabbage (20 mg/100 g). There is considerable variation in the values reported for the same vegetable by different studies, with a median difference between the minimum and maximum values of 5·8-fold. Limited analysis of cooked cruciferous vegetables has been conducted; however, the available data show that average losses during cooking are approximately 36 %. This is the first attempt to collate the available literature on the glucosinolate content of cruciferous vegetables. These data will allow quantification of intakes of the glucosinolates, which can be used in epidemiological studies to investigate the role of cruciferous vegetables in cancer aetiology and prevention.

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“…Oxalates may reduce the bioavailability of calcium and magnesium and are a potential risk factor for kidney stone development 12. Cytotoxic activity associated with BITC includes decreased levels of blood haemoglobin, impaired kidney functions and microscopic hepatic changes 13–15. Irreversible neurological disorders have been documented with regular dietary intake of HCN 16–19.…”

Section: Introductionmentioning

confidence: 99%

Assessment of compositional changes during ripening of transgenic papaya modified for protection against papaya ringspot virus

et al. 2008

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BACKGROUND: Papaya (Carica papaya L.) production is limited by over 20 viruses, the most damaging of which is papaya ringspot virus (PRSV). Owing to a lack of suitable PRSV-resistant sources in Carica germplasm, transgenic resistance using the coat protein (cp) gene of a local PRSV strain is being developed to manage the disease in Jamaica. For assurance of food safety, the nutritional and antinutritional composition of transgenic papayas during ripening was compared with that of unmodified control samples.

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Effects of high levels of Brussels sprouts in the diet of rats

Cited by 31 publications

References 32 publications

Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects

Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects

Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables

Assessment of compositional changes during ripening of transgenic papaya modified for protection against papaya ringspot virus

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