Effects of high-intensity interval training in patients with coronary artery disease after percutaneous coronary intervention: a systematic review and meta-analysis

Abstract

Background: High-intensity interval training, for its characteristic of short-time high oxygen-consumption exercise interphase with periods of low-intensity training or rest for recovery, is easier to persist and execute in cardiac rehabilitation. However, it is little known whether HIIT program has an advantageous effect on patients after percutaneous coronary intervention or not. Methods: Randomized controlled trials (RCTs) focusing on HIIT program in patients after PCI were searched in Cochrane Library, Web of Science Core Collection, EMbase, PubMed, China National Knowledge Infrastructure (CNKI) and SinoMed from the inception to March 24, 2020. Two reviewers conducted the literature retrieval, data extraction, and quality assessment independently. Standard Mean difference (SMD) and 95% confidence intervals (CI) were performed to summarize the effect sizes. Results: 6 RCTs (247 patients) met the criteria. HIIT program had a statistically significant effect on raising left ventricular ejection function (LVEF) (SMD=0.38, 95%CI[0.03, 0.73], p=0.03), VO2peak (SMD=0.94, 95%CI[0.61, 1.28], p<0.01), as well as improving the serum level of high-density lipoprotein (SMD=0.55, 95%CI[0.06, 1.03], p=0.03) and late luminal loss (SMD=-0.65, 95%CI[-1.07, -0.23], p<0.01). But HIIT had no prominent effect on improving heart rate (SMD=-0.04, 95%CI[-0.29, 0.21], p=0.73). Conclusions: HIIT program might be favorable for CAD patients after PCI by improving cardiopulmonary function, such as LVEF and VO2peak, as well as reducing late luminal loss in per stented arteries. Nevertheless, HIIT had no advantage for adjusting heart rate. More researches with rigorous methods are warranted to explore the controversy about lipid profiles.

The Effectiveness of Bax/Bcl-2 Gene Expression Ratio, Cardiac Function and Pulmonary Hemodynamics Indexes caused by Cardiopulmonary Rehabilitation Nursing

“…Fu C et al (11) believed that rehabilitation exercise after PCI could reduce the risk of coronary artery restenosis and avoid lumen loss at the later stage of the stent coronary artery segment. A Chinese scholar found that personalized exercise training in cardiac rehabilitation could improve cardiac function and exercise endurance, which is an important means of secondary prevention after PCI (12). Therefore, in the perioperative period of PCI for coronary heart disease patients, individualized exercise rehabilitation nursing can be used to reduce the risk of postoperative readmission and promote the improvement of cardiac function indexes.…”