Effects of high fructose corn syrup on intestinal microbiota structure and obesity in mice

Abstract

High fructose corn syrup (HFCS)-associated health problems have raised concerns. We investigated the effects of HFCS-containing drinking water on body fat, intestinal microbiota structure of mice, and the relationships between them. HFCS drinking water significantly increased body fat content and altered the intestinal microbiome. The Christensenellaceae R-7 group negatively correlated with body weight, perirenal fat, epididymal fat, and liver fat percentage.

Seasonal variations in gut microbiota of semiprovisioned rhesus macaques (Macaca mulatta) living in a limestone forest of Guangxi, China

“…We also discovered that the cellulose-fermenting bacteria belonging to Firmicutes, such as UCG-002 , UCG-005 , and unclassified_f__Lachnospiraceae, is still high in relative abundance during the rainy season ( Guo et al, 2020 ; Liao et al, 2021 ; Wang et al, 2022 ). This trend is consistent with their multifaceted diet with provisioned and natural foods.…”

“…Specifically, the macaques in limestone forests primarily obtain leaves as food ( Wang et al, 1994 ), in which the decomposition of cellulose is inseparable from their gut microbiota. Proteobacteria, Actinobacteria, and Spirochaetes are the common taxa in the animal guts ( Hicks et al, 2018 ; Li et al, 2019 ; Wang et al, 2022 ). Although some bacteria in Proteobacteria are associated with diseases ( Marchesi et al, 2016 ; Orkin et al, 2019 ), we discovered that the Succinivibrio , which dominates, is committed to breaking down the polysaccharides and enhancing the degradation of food ( Baniel et al, 2021 ).…”

“…The dominant bacterial taxa’s approximate change in relative abundance was consistent with prediction 2. The proportion of Firmicutes was significantly higher in the dry season than in the rainy season, and the common taxa in Firmicutes, such as Lachnospiraceae and Clostridiaceae, are necessary for cellulose decomposition in herbivorous animals ( Ley et al, 2008 ; Wang et al, 2022 ). Notably, these bacteria can degrade numerous complex polysaccharides to produce short-chain fatty acids for easy absorption, provide energy to the host ( Zhu et al, 2011 ; Hale et al, 2019 ).…”

“…Further research has shown that the diversity and composition of the gut microbiota affect the host’s health ( Marchesi et al, 2016 ), digestion ( Zhu et al, 2011 ; Flint et al, 2012 ), and behavior ( Hsiao et al, 2013 ), and that it may even be considered in other essential organs ( O’Hara and Shanahan, 2006 ). Many factors affect the composition and diversity of the gut microbiota, including diet ( Filippo et al, 2010 ; David et al, 2014 ; Merra et al, 2021 ; Wang et al, 2022 ), host characteristics ( Goodrich et al, 2014 ; Li et al, 2021 ), social contacts ( Sarkar et al, 2020 ), and environment ( Li et al, 2019 ; Wu et al, 2022 ). The diet is the most significant factor and even outweighs host genetics ( Hale et al, 2018 ).…”

Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs

“…In growing pigs, the relative abundance of Lachnospiraceae XPB1014 group was negatively associated with body fat weight [ 29 ]. Moreover, a decreased Christensenellaceae R-7 group was regarded as a contributor to high fructose corn syrup-induced obesity, and a positive association was found between changes in body weight and Christensenellaceae R-7 group [ 30 , 31 ]. At the genus level, the increased relative abundances of the Lachnospiraceae XPB1014 group and the Christensenellaceae R-7 group were achieved in the −10% group and the −20% group.…”