Effects of High-Fat Diets from Different Sources on Serum and Thymus Lipid Profile: Study in an Experimental Model

Silva, Carolina; Perris, Paula; Fernandez, Inés; Godoy, María Fernanda; Mambrin, Cecilia; Slobodianik, Nora; Feliu, Marı́a Susana

doi:10.2174/1871530314666140519160607

Cited by 4 publications

(3 citation statements)

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“…Trabajos previos de nuestro grupo han demostrado que, la administración al destete de dietas ricas en ácidos grasos saturados como es el caso de la manteca y con alto contenido de Kcal lipídicas (F% 40) durante 10 días post destete, así como, dietas normocalóricas (F% 15) pero administradas por un tiempo mayor (40 días), afectan la concentración de TG en suero, provocando un incremento significativo de esta fracción, con posibilidad de aumento del riesgo de padecer enfermedades crónicas 30,31 . Sin embargo, en la presente investigación no se observaron diferencias significativas en la concentración de TG séricos, independientemente de la fuente de suplemento utilizado.…”

Section: Resultsunclassified

Efecto de la suplementación con ácidos grasos n-3 sobre el perfil de lípidos séricos de ratas

et al. 2021

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Section: Resultsunclassified

Efecto de la suplementación con ácidos grasos n-3 sobre el perfil de lípidos séricos de ratas

et al. 2021

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“…Among these, HFD 3, characterized by the highest content of saturated fatty acids and total calories, along with the group containing solely the trans fatty acid component, exhibited the highest values, followed by HFD 2 and HFD 1. Different diets containing high fat levels will result in different levels of profile lipid [34]. Moreover, the effect of a high-fat diet on body weight was also analyzed.…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diet Enhances Platelet Activation and Is Associated with Proprotein Convertase Subtilisin Kexin 9: An Animal Study

Saputri,

Azmi,

Puteri

et al. 2023

Nutrients

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Platelet activation and proprotein convertase subtilisin kexin 9 (PCSK9) play pivotal roles in the progression of atherosclerosis to cardiovascular events. It has been reported that hyperlipidemia, a well-documented risk factors for cardiovascular diseases, tends increase platelet activation and PCSK9 expression. However, little is known about this specific mechanism, particularly how nutrition affects platelet activation and PCSK9 levels in hyperlipidemia conditions. This study aimed to assess how a high-fat diet influences platelet activation, its association with PCSK9, and the effects on blood pressure in an animal model. Here, male Wistar rats were divided into four groups, subjected to different high-fat diets for ten weeks with varying nutrient components. The results showed that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia significantly increased the plasma levels of β-thromboglobulin (β-TG), p-selectin, and platelet factor 4 (PF-4). The blood pressure readings were also elevated post high-fat diet induction. Interestingly, the group with the highest percentage of saturated fatty acid and trans-fat exhibited the highest PCSK9 levels, along with the highest increase in plasma cholesterol, triglycerides, and platelet activation parameters. These findings confirm that high-fat diet-induced hypercholesterolemia and hypertriglyceridemia stimulate platelet activity and PCSK9 levels. Moreover, our results suggest that PCSK9, implicated in hypercholesterolemia and hypertriglyceridemia, may synergistically mediate platelet hyperactivity, aligning with clinical studies. Notably, our results highlight the association between a high-fat diet and PCSK9, providing insights for drug discovery targeting platelet activation in atherosclerosis-induced cardiovascular diseases.

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“…It is well known that adult human thymus degenerates into fat tissue. 15 A recent experimental study by Silva revealed that high-fat diets resulted in the abnormal thymus lipid profile, 16 indicating that the lipid metabolism produces great effects on the structure and function of thymus. The excessive accumulation of fat in thymus presumably would increase the likelihood of malignant transformation of thymic epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Pulmonary Function in Thymoma Subjects: A 20-Year Retrospective Cohort Study

Liu

Yang

Shang

et al. 2022

Thorac Cardiovasc Surg

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Background Thymoma is the most common tumor of the anterior mediastinum. However, the correlation between thymoma stage and pulmonary function was not assessed. Our objective in this study was to describe the pulmonary function in thymoma subjects stratified with different staging systems. Methods A total of 143 subjects with a diagnosis of thymoma who underwent extended thymectomy for thymoma between January 2001 and December 2019 were reviewed retrospectively. All the subjects experienced pulmonary function tests (PFTs) using Master Screen PFT system and total respiratory resistance measurement. Results We evaluated 143 subjects with a diagnosis of thymoma; the significant differences were observed in mean values of vital capacity, inspiratory volume (IC), total lung capacity (TLC), ratio of residual volume to total lung capacity (RV/TLC), forced vital capacity, forced expiratory volume in 1 second, ratio of forced expiratory volume in 1 second to forced vital capacity, peak expiratory flow, peak inspiratory flow, maximum ventilation volume, total airway resistance, and diffusing capacity for carbon monoxide (DLCO) across upper airway obstruction classification. PFTs of subjects with varying Masaoka stages are different. RV and RV/TLC of subjects in stages III and IV were higher than those of normal level, while DLCO of subjects in stage IV was lower than the normal level, and the mean level of IC showed significant difference between stage II and stage III. Discussion The pulmonary function patterns of thymoma subjects significantly correlate with tumor location and size rather than clinical Masaoka stage.

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Effects of High-Fat Diets from Different Sources on Serum and Thymus Lipid Profile: Study in an Experimental Model

Cited by 4 publications

References 0 publications

Efecto de la suplementación con ácidos grasos n-3 sobre el perfil de lípidos séricos de ratas

Efecto de la suplementación con ácidos grasos n-3 sobre el perfil de lípidos séricos de ratas

High-Fat Diet Enhances Platelet Activation and Is Associated with Proprotein Convertase Subtilisin Kexin 9: An Animal Study

Analysis of Pulmonary Function in Thymoma Subjects: A 20-Year Retrospective Cohort Study

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