Effects of high-carbohydrate diets on lipogenesis in rat interscapular brown adipose tissue

Abstract

Cycloplasmic preparations from brown and white adipose tissues were assayed for three lipogenic enzymes throughout a programme of starvation followed by refeeding on either a normal or a white-bread diet. In the brown adipose tissue of rats fed on a white-bread diet the three enzymes were elevated to levels significantly higher than those in white adipose tissue.

Fatty acid synthesis in liver and adipose tissue

“…Comparisons of fatty acid synthesis in white and brown adipose tissues have shown that in rats (Agius & Williamson, 1980) and mice (Rath et al 1979;Trayhurn, 1981) the rate of synthesis is many times greater in the latter tissue. Fatty acids, synthesized in situ, may be the substrates oxidized during dietary-induced thermogenesis (Agius & Williamson, 1980;Weaire & Kanagasabai, 1982).…”

Does the glycogen synthase (EC 2.4.1.21) of brown adipose tissue play a regulatory role in glucose homeostasis?

“…In the metabolism studies with BAT reported in the literature, emphasis was placed on lipogenesis (Sugden et al 1982;Wearire & Kanagasabai, 1982;Himns-Hagen, 1985 ;McCormack et al 1986), consequently, only those enzymes involved in this pathway were investigated. It became apparent, however, that BAT plays different metabolic roles and that various metabolic pathways, and the enzymes involved in these pathways, may change with the physiological situation (starvation or refeeding), e.g.…”