Effects of high altitude and water deprivation on arginine vasopressin release in men

Maresh, C. M.; Kraemer, William J.; Judelson, Daniel A.; VanHeest, Jaci L.; Trad, L. A.; Kulikowich, Jonna M.; Goetz, K. L.; Cymerman, Allen; Hamilton, Allan J.

doi:10.1152/ajpendo.00332.2003

Cited by 25 publications

(19 citation statements)

References 22 publications

(41 reference statements)

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“…Highaltitude exposure has been repeatedly shown to be associated with increased diuresis and natriuresis, and secondary haemoconcentration with decreased effective plasma volume [32,33]. These effects are essentially related to decreased ADH and aldosterone signalling at the collecting ducts [32,33]. Healthy volunteers rapidly brought to the altitude of 4,559 m typically presented with increased diuresis, CH 2 O/GFR and FE Na, in keeping with decreased renal tubular actions of both ADH and aldosterone [10].…”

Section: Discussionmentioning

confidence: 98%

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Pulmonary artery pressure limits exercise capacity at high altitude

Naeije¹,

Huez²,

Lamotte³

et al. 2010

European Respiratory Journal

100

108

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Altitude exposure is associated with decreased exercise capacity and increased pulmonary vascular resistance (PVR).Echocardiographic measurements of pulmonary haemodynamics and a cardiopulmonary exercise test were performed in 13 healthy subjects at sea level, in normoxia and during acute hypoxic breathing (1 h, 12% oxygen in nitrogen), and in 22 healthy subjects after acclimatisation to an altitude of 5,050 m. The measurements were obtained after randomisation, double-blinded to the intake of placebo or the endothelin A receptor blocker sitaxsentan (100 mg?day -1 for 7 days). Blood and urine were sampled for renal function measurements. Normobaric as well as hypobaric hypoxia increased PVR and decreased maximum workload and oxygen uptake (V9O 2 ,max). Sitaxsentan decreased PVR in acute and chronic hypoxia (both p,0.001), and partly restored V9O 2 ,max, by 30 % in acute hypoxia (p,0.001) and 10% in chronic hypoxia (p,0.05). Sitaxsentan-induced changes in PVR and V9O 2 ,max were correlated (p50.01). Hypoxia decreased glomerular filtration rate and free water clearance, and increased fractional sodium excretion. These indices of renal function were unaffected by sitaxsentan intake.Selective endothelin A receptor blockade with sitaxsentan improves mild pulmonary hypertension and restores exercise capacity without adverse effects on renal function in hypoxic normal subjects.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Pulmonary artery pressure limits exercise capacity at high altitude

Naeije¹,

Huez²,

Lamotte³

et al. 2010

European Respiratory Journal

100

108

View full text Add to dashboard Cite

show abstract

“…A recent study has shown that chronic hypoxia causes marked activation of the sympathetic nervous system in healthy humans and increased SBP, despite normalisation of the arterial O 2 content with acclimatisation (24) . Increased secretion of catecholamine (24,25) , vasopressin (26) and adrenocorticotropin (27) may promote the development of hypertension by the renin-angiotensin-aldosterone system (28) . Corn gruel or hoecake is the staple food throughout the year in Hei Yi Zhuang.…”

Section: Discussionmentioning

confidence: 99%

Association of diet and lifestyle with blood pressure in the Guangxi Hei Yi Zhuang and Han populations

Yin

et al. 2008

PHN

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Objective: To detect the association of diet and lifestyle with blood pressure in the Guangxi Hei Yi Zhuang and Han populations. Design: A cross-sectional study of hypertension. Setting: Both populations were from seven to nine villages in Napo County, Guangxi Zhuang Autonomous Region, China. Subjects: A total of 1068 subjects of Hei Yi Zhuang and 933 participants of Han Chinese aged 20-89 years were surveyed by a stratified randomised cluster sampling. Results: The levels of systolic blood pressure and pulse pressure were higher in Hei Yi Zhuang than in Han (125?20 (SD 18?62) v. 121?88 (SD 15?99) mmHg and 48?64 (SD 14?75) v. 44?98 (SD 11?12 ) mmHg, P , 0?001 for each, respectively). The prevalence of hypertension and isolated systolic hypertension was also higher in Hei Yi Zhuang than in Han (25?19 % v. 17?26 % and 12?45 % v. 3?86 %, P , 0?001 for each, respectively). Mean arterial pressure was positively correlated with gender, age, physical activity, TAG, alcohol consumption, cigarette smoking, total energy, total fat and salt intakes, and negatively associated with education level and total dietary fibre intake in Hei Yi Zhuang (P , 0?05-0?001), whereas it was positively associated with gender, age, physical activity, BMI, waist circumference, total cholesterol, alcohol consumption, cigarette smoking, total energy, total fat and salt intakes, and negatively associated with education level and total dietary fibre intake in Han (P , 0?05-0?001). Conclusions: The differences in blood pressure levels and the prevalence of hypertension between the Hei Yi Zhuang and Han populations were associated with different dietary habits, lifestyle choices, education level, as well as geographical surroundings.

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“…6 A second relevant component of adaptation to altitude is an increase in urinary volume, associated with a reduced renal sensitivity to arginine vasopressin (AVP). 7 Recent studies revealed that the lack of increase in urinary volume and free water clearance has a relevant prognostic value for the onset of acute mountain sickness (AMS) in mountaineers reaching a high altitude (4880 m). 8 ET-1 is produced in the kidney, where it functionally antagonizes AVP.…”

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confidence: 99%

Role of Endothelin-1 in Exposure to High Altitude

et al. 2006

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Background-The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia. Methods and Results-In a double-blind fashion, healthy volunteers were randomly assigned to receive bosentan (62.5 mg for 1 day and 125 mg for the following 2 days; nϭ10) or placebo (nϭ10) at sea level and after rapid ascent to high altitude (4559 m). At sea level, bosentan did not induce any significant changes in hemodynamic or renal parameters. At altitude, bosentan induced a significant reduction of systolic pulmonary artery pressure (21Ϯ7 versus 31Ϯ7 mm Hg, PϽ0.03) and a mild increase in arterial oxygen saturation versus placebo after just 1 day of treatment. However, both urinary volume and free water clearance (H 2 OCl/glomerular filtration rate) were significantly reduced versus placebo after 2 days of ET-1 antagonism (1100Ϯ200 versus 1610Ϯ590 mL; Ϫ6.7Ϯ3.5 versus Ϫ1.8Ϯ4.8 mL/min, PϽ0.05 versus placebo for both). Sodium clearance and segmental tubular function were not significantly affected by bosentan administration. Conclusions-The present results indicate that the early beneficial effect of ET-1 antagonism on pulmonary blood pressure is followed by an impairment in volume adaptation. These findings must be considered for the prevention and treatment of acute mountain sickness.

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Effects of high altitude and water deprivation on arginine vasopressin release in men

Cited by 25 publications

References 22 publications

Pulmonary artery pressure limits exercise capacity at high altitude

Pulmonary artery pressure limits exercise capacity at high altitude

Association of diet and lifestyle with blood pressure in the Guangxi Hei Yi Zhuang and Han populations

Role of Endothelin-1 in Exposure to High Altitude

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