Effects of hepatic stimulator substance, herbal medicine, selenium/vitamin E, and ciprofloxacin on cirrhosis in the rat

Decreased hepatocyte membrane potential differences and GABAa-β3 expression in human hepatocellular carcinoma

“…6,7 Conversely, when GABA A receptors were down-regulated, hepatocyte PDs were depolarized, and proliferative activity was increased. 8,9 Another electrogenic system that may play an important role in regulating hepatocyte PDs is the Na/K adenosine triphosphatase (ATPase) system. Like the GABAergic system, increased Na/K-ATPase activity results in hyperpolarization and inactivation/depolarization of hepatocyte PDs.…”

Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis

“…Therapeutically, the administration of exogenous HSS protein stimulated hepatocyte proliferation (54) and reversed experimental hepatic fibrosis (16). These results indicate that HSS acts as a growth-promoting factor that induces hepatocyte proliferation and also as a potential therapeutic agent that protects the liver.…”

Effect of preoperative interventions on outcome following liver resection in a rat model of cirrhosis

“…A recent study examined the effects of ciprofloxacin on the liver in a CCI, -induced rat model of cirrhosis [168]. .…”

“…The final group of cirrhotic rats received 1 cc 1 200 grams body weight of a concentrated formulation of a traditional Chinese herbal remedy (TCHR), which contains ginseng, pangolin shell, and leeches as the principal ingredients [77].…”

“…The dosages selected were based on the results of previous studies using these agents in rat models of advanced liver disease [20, 77,1661. CCI, injections were continued weekly during this treatrnent phase of the study to prevent spontaneous reversion of the cirrhosis.…”