“…Conversely, heparin, and a low molecular weight heparin analogue, enoxaparin, have also been shown to inhibit BACE1 processing of APP through a dose-dependent decrease in sAPPβ secretion as well as C99 production [140]. Further this effect was not specific for BACE1, as levels of ADAM10, the most likely α -secretase candidate, were also decreased following GAG administration, along with α-secretase related APP processing products, indicating that administration of GAGs interferes with general processing of APP [140]. Further this effect was not specific for BACE1, as levels of ADAM10, the most likely α -secretase candidate, were also decreased following GAG administration, along with α-secretase related APP processing products, indicating that administration of GAGs interferes with general processing of APP [140].…”