Effects of hemostatic agents on the pH of body fluids

Bjorenson, Jean E.; Grove, Henry F.; List, Sr. M. Gloria; Haasch, Gregory C.; Austin, B.P.

doi:10.1016/s0099-2399(86)80110-8

Cited by 31 publications

(26 citation statements)

References 8 publications

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“…In previously published data surgicel was found to cause significant decreasing pH of blood, plasma [11] and surrounding tissues [12]. Borenson et al [11] demonstrated in animal model decrease of pH values of heaprinized blood and plasma to less than 6.5 -6.0 after the surgicel presentation. Some patients notice irritation and report of "burning" sensation related to low pH of surgicel after use it as packing in epistaxis, and other rhinological procedures [3].…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

“…A major component of surgicel hemostatic effect is based on low pH mechanism [11]. In previously published data surgicel was found to cause significant decreasing pH of blood, plasma [11] and surrounding tissues [12]. Borenson et al [11] demonstrated in animal model decrease of pH values of heaprinized blood and plasma to less than 6.5 -6.0 after the surgicel presentation.…”

Section: Discussionmentioning

confidence: 99%

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Surgicel Induced Intraoperative Cardiovascular Collapse in a Child with Midbrain Glioma

Brotfain¹,

Korn²,

Gidon³

et al. 2015

CRCM

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Introduction: Intraoperative cardiovascular complications were previously demonstrated in relation to high sympathetic nervous system outflow or stimulation of the vagal nerve nucleus during theneurosurgical procedures on brain tumors. Main Symptoms and Important Clinical Findings: We are presenting clinical case of 13-year-old girl who suffered from midbrain glioma and developed life threatening cardiovascular events during neurosurgical procedure after surgicel hemostatic agent application. Therapeutic Interventions and Outcomes: Cardiovascular stability has been restored after immediate removal of surgicel from the operating field. We believe that it might be related to direct application of the surgicel hemostatic agent.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Surgicel Induced Intraoperative Cardiovascular Collapse in a Child with Midbrain Glioma

Brotfain¹,

Korn²,

Gidon³

et al. 2015

CRCM

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“…For this purpose, Surgicel™ and other similar materials are currently available on the market. Bjorenson et al and Spiller et al focused on the effect of absorbable topical haemostatic agents on the relaxation of time blood on in vitro study (1,10), emphasizing that even if Surgicel™ is the most widely used in neurosurgery, it can develop local inflammation presumably due to its acidity (1,2,4). Furthermore, oxidized regenerated cellulose, affecting the 1/T 1 of blood, is likely to alter post-operative MR images, causing misinterpretations.…”

Section: Surgical Considerationsmentioning

confidence: 99%

Foreign Body Reaction Mimicking Intracranial Abscess following the Use of Oxidized Regenerated Cellulose (SurgicelTM): Case Report and Literature Review

Capozza

Pansini

Buccoliero

et al. 2016

IrJNS

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“…In spite of its benefits, use of absorbable hemostatic agents may not necessarily be without risk and may cause a probiotic microenvironment that can contribute to bacterial proliferation. [5][6] A study performed by Anderson et al 7 investigated the association of gelatinthrombin matrix use and abscess formation in patients undergoing hysterectomy and found that nine patients developed an abscess with gelatin-thrombin use as opposed to only two patients who developed an abscess in the absence of gelatin-thrombin use. However, no study to date has assessed the association between routine absorbable hemostatic agent use, as a means of preventing post-operative bleeding, and post-operative fever and abscess formation in women undergoing cesarean delivery.…”

Section: Introductionmentioning

confidence: 99%

Post-Operative Outcomes of Oxidized Regenerated Cellulose Use in Women Undergoing Cesarean Delivery

Abraham¹

2017

Gynecol Obstet Res Open J

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To assess post-operative outcomes associated with routine use of oxidized regenerated cellulose at the time of cesarean delivery Methods: Retrospective chart review of cesarean deliveries divided into two groups: Those in which oxidized regenerated cellulose was used and those in which it wasn't. Following data were obtained: Maternal baseline characteristics, estimated blood loss, pre-and post-operative complete blood counts and incidence of fever and post-operative abscess. Student t-test and Chi-square were used for statistical analysis. Results: Of 155 patients, oxidized cellulose was used in 77 (50%). Baseline characteristics between groups were similar. Mean estimated blood loss was not significantly different between groups (803 mL vs 800 mL, p=0.32). Increase in pre-and post-operative white blood cell count (3.5 vs. 3.3, p=0.65) and decreases in pre-and post-operative hemoglobin (1.7 vs. 1.9, p=0.21) and hematocrit (4.5 vs. 5.1, p=0.29) were not significantly different between groups. However, there was a significantly increased incidence of fever in the group in which oxidized cellulose was used (13.0% vs. 3.9%, p<0.05). Abscess formation did not occur in either group. Conclusion: Oxidized regenerated cellulose use was associated with an increased incidence of post-operative fever without significantly affecting changes in pre-and post-operative hemoglobin and hematocrit.

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Effects of hemostatic agents on the pH of body fluids

Cited by 31 publications

References 8 publications

Surgicel Induced Intraoperative Cardiovascular Collapse in a Child with Midbrain Glioma

Surgicel Induced Intraoperative Cardiovascular Collapse in a Child with Midbrain Glioma

Foreign Body Reaction Mimicking Intracranial Abscess following the Use of Oxidized Regenerated Cellulose (SurgicelTM): Case Report and Literature Review

Post-Operative Outcomes of Oxidized Regenerated Cellulose Use in Women Undergoing Cesarean Delivery

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