Effects of hemorrhage and chronic sodium depletion on hepatic clearance of renin

Johnson, J. A.; Davis, JO; Baumber, JS; Schneider, E. G.

doi:10.1152/ajplegacy.1971.220.6.1677

Cited by 28 publications

(14 citation statements)

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“…Michelakis and Mizukoshi reported that the disappearance rate of renin in man after nephrectomy was approximately 14 min (24). Furthermore, there is recent evidence that the hepatic clearance of renin is influenced by sodium intake, with sodium depletion decreasing hepatic clearance of renin (25). Because of these difficulties, it is not possible to determine in the present study the biologic half-life of renin precisely.…”

Section: Discussionmentioning

confidence: 76%

A Specific Role for Saline or the Sodium Ion in the Regulation of Renin and Aldosterone Secretion

Tuck¹,

Dluhy²,

Williams³

1974

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 76%

A Specific Role for Saline or the Sodium Ion in the Regulation of Renin and Aldosterone Secretion

Tuck¹,

Dluhy²,

Williams³

1974

J. Clin. Invest.

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“…PRC rose more than the number of renin granules per arteriole (20-fold increase), which could be due to a more rapid turnover rate in the renin-producing cells, but a reduced hepatic clearance of renin may also contribute (Johnson et al 1971).…”

Section: Discussionmentioning

confidence: 95%

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Rasch

Jensen

Nyengaard

et al. 1998

Cell and Tissue Research

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In order to study the cellular mode of renin secretion, stereological methods were used to estimate number and volume of rat renin secretory granules during stimulation of the renin system. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min increased plasma renin concentration (PRC) twofold, but did not significantly change the number of renin granules per arteriole or the renin-containing volume of the arteriole. Chronic stimulation was achieved by a combination of low-salt diet and inhibition of angiotensin-converting enzyme (ACE) for 14 days, and resulted in a 36-fold increase in PRC, a 20-fold increase in the number of granules per arteriole, and a 17-fold increase in the arteriolar volume that contained renin. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min in the chronically stimulated rats increased PRC further (1.6-fold), and significantly reduced the number of granules per arteriole by 4000 (45% reduction), but did not change the renin-containing arteriolar volume significantly. The average renin granule size was 0.35 microm3 with no significant differences among the groups. We conclude that recruited granular cells contribute significantly to renin release, and that all granular cells along the arteriole participate in secretory responses. The reduced number of renin granules after acute stimulation is compatible with exocytosis as the dominating mechanism of renin release.

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“…Hepatic clearance of renin has been documented (9,23) and found to change with hemorrhage and salt depletion (9). One might, therefore, expect that during the post natal period, a temporal delay may occur in the development of this function.…”

Section: Discussionmentioning

confidence: 99%

Postnatal Changes in Plasma and Renal Renin of the Rat

Solomon¹,

Iaina²,

Eliahou³

et al. 1977

Neonatology

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Plasma renin activity (PRA) of infant rats is high until some time between the 3rd and 4th week after birth. Mothers, however, return PRA to normal by 2 weeks post partum. The rate of disappearance of endogenous PRA of nephrectomized rats is slower in those animals having high PRA than in mature rats. Disappearance curves of endogenous PRA of mothers post partum is also the same as that of normal mature females. Part of the high PRA of the neonate can thereby be related to the lower rate of destruction. Total kidney renin content increases with age. Renal renin activity (RRA) is low only during the 1st postnatal week when expressed in terms of whole kidney weight and compared to later postnatal times. Although there are some slight differences in the means in older animals, none are statistically significant.

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Effects of hemorrhage and chronic sodium depletion on hepatic clearance of renin

Cited by 28 publications

References 0 publications

A Specific Role for Saline or the Sodium Ion in the Regulation of Renin and Aldosterone Secretion

A Specific Role for Saline or the Sodium Ion in the Regulation of Renin and Aldosterone Secretion

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Postnatal Changes in Plasma and Renal Renin of the Rat

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