Effects of Hemolyzed Blood on Coronary Blood Flow

Chambliss, J. R.; Demming, J.; Wells, Kip E.; Cline, W. W.; Eckstein, Richard W.

doi:10.1152/ajplegacy.1950.163.3.545

Cited by 18 publications

(3 citation statements)

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“…It should also be remembered that vasodilators, probably adenosine triphosphate, are released when erythrocytes break down (Freund, 1920;Fleisch, 1937). Chamblis, Demming, Wells, Cline, and Eckstein (1950) found that the yield from O.OOO~ ml. of blood increased the coronary artery flow when injected directly.…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric bloodless perfusion of the kidney

Anderson

1966

Journal of British Surgery

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Section: Discussionmentioning

confidence: 99%

Hyperbaric bloodless perfusion of the kidney

Anderson

1966

Journal of British Surgery

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“…The absence of hemolysis on spectrophotometric examination makes this unlikely, although minute amounts of hemolysis can be responsible for market hemodynamic changes. [28][29][30] It seemed possible that some of the hemo-dynamic changes could be the result of a high-pressure rapid injection, since the existence of pressor receptors in the left heart chambers31 has been postulated. The failure of injections of isotonic saline in dogs to elicit significant hemodynamic changes rules out the mechanical effect of injections as an important contributor to the reaction.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic Consequences of the Injection of Radiopaque Material

et al. 1965

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ANGIOCARDIOGRAPHY and cineangiocardiography are employed with increasing frequency for the diagnosis of cardiovascular diseases. These commonplace technics of cardiovascular radiology depend upon the rapid injection of radiopaque materials into the heart or central circulation. A wide variety of substances are in use, but all are hypertonic and some are considerably more viscous than blood. A variety of studies are available to indicate that the hemodynamic effects can be related to chemical structure, -3 but as newer and safer agents have become available it seems clear that the pharmacodynamic effects are related most importantly to the hypertonicity of these compounds. The effects of the injection of oontrast media can therefore be considered to be the effects of hypertonicity on the circulation, and the study of these effects assumes considerable practical importance.Numerous reports are available that deal with the effects of hypertonic (and radiopaque) materials injected into the right heart and pulmonary circulation in animals,4-10 but comparable systematic studies in man are not available. The hemodynamic consequences associated with the injection of radiopaque ma-From the

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“…Vasodilatation produced by forceful intra-arterial injection; mechanical fragility of erythrocytes The possibility that turbulent flow created by high velocity injection might destroy erythrocytes was suggested (18) in studies on the vasodilating properties of hemolyzed blood in the perfused coronary circulation of the dog.8 The observation arose from the discovery that rapid injection of any liquid through a 27-gauge needle produced vasodilatation which was accompanied by destruction of erythrocytes. These investigators and, independently, Binet and Burstein (19) confirmed previous studies of Fleisch (20) indicating that the vasodilating property of hemolyzed blood was dependent on adenosine triphosphate, and perhaps related substances, released from erythrocytes.…”

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confidence: 99%

Measurement of Blood Flow and Volume in the Forearm of Man; With Notes on the Theory of Indicator-Dilution and on Production of Turbulence, Hemolysis, and Vasodilatation by Intra-Vascular Injection 1

Andres¹,

Zierler²,

Anderson³

et al. 1954

J. Clin. Invest.

144

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In the course of a series of studies on neuromuscular function it became desirable to investigate in man the metabolism of skeletal muscle in situ.For this purpose it was decided to apply the Zuntz-Fick principle to determine the exchange of metabolites between muscle and blood in the forearm with circulation occluded at the wrist.The selection of this segment was guided by the following considerations: (a) Convenience; (b) the large muscular volume relative to the volume of skin (1); (c) the predominance of blood flow through muscle relative to skin (2, 3); and (d) the relative avascularity of other structures suggesting that no less than 80 per cent of total forearm blood flow is muscular in distribution.In addition to the estimation of arterio-venous concentration differences in substances of interest, the principle requires a measurement of blood flow through the segment under study. Of methods in current use, only venous-occlusion plethysmography provides an absolute numerical value for blood flow through a human extremity. Despite the wealth of observations recorded by this method it was deemed desirable to develop another approach which might yield continuous recording of blood flow as well as serial samples of arterial and venous blood. Furthermore, the sources of error of the plethysmographic method have been studied carefully but not overcome completely (4), and, to our knowledge, no verification of the method by an independent technic has been made in man.

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Effects of Hemolyzed Blood on Coronary Blood Flow

Cited by 18 publications

References 0 publications

Hyperbaric bloodless perfusion of the kidney

Hyperbaric bloodless perfusion of the kidney

Hemodynamic Consequences of the Injection of Radiopaque Material

Measurement of Blood Flow and Volume in the Forearm of Man; With Notes on the Theory of Indicator-Dilution and on Production of Turbulence, Hemolysis, and Vasodilatation by Intra-Vascular Injection 1

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