Effects of hemodialysis on serum lipids and phospholipids of end-stage renal failure patients

Piperi, Christina; Kalofoutis, Christos; Tzivras, Michalis; Troupis, Theodore; Skenderis, A; Kalofoutis, A.

doi:10.1023/b:mcbi.0000044315.74038.78

Cited by 22 publications

(19 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with recent studies [19,20], we found that HDL2 and HDL3-C levels are decreased in the serum of HD patients compared to normal controls. Although HDL metabolism is regulated by several enzymes, such as hepatic triglyceride lipase, cholesterylester transfer protein and LCAT, there is limited evidence in the literature about the involvement of the first two of these in the distribution of HDL2 and HDL3-C subclasses in HD patients [33].…”

Section: Discussionsupporting

confidence: 93%

“…In this study, we examined the association of oxLDL with lipids, lipoproteins and apolipoproteins, as well as with CRP in patients with end-stage renal failure on HD. We focused on the association of oxLDL with HDL2 and HDL3-C subclasses, which have differences in their chemical composition and have been proved to be affected by HD [19,20]. This analysis may provide additional information about the effects of oxidative stress on HDL-C activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Samouilidou

Karpouza²,

Grapsa³

et al. 2010

Nephron Clin Pract

View full text Add to dashboard Cite

Background:Dyslipoproteinemia and oxidative modification of LDL (oxLDL) are common symptoms in patients suffering from chronic renal failure on hemodialysis (HD), and contribute to the development of oxidative stress. High-density lipoprotein cholesterol (HDL-C) protects against atherosclerosis by inhibiting the oxidation of lipoproteins and by supporting reverse cholesterol transport. This study intends to examine the association of oxLDL with HDL2 and HDL3 subclasses of HDL-C in HD patients, in order to elucidate whether oxidative stress influences HDL-C composition. Methods: Thirty-four patients on HD and 21 age- and sex-matched controls were studied. HDL2 and HDL3-C subclasses were isolated from serum according to a single-step precipitation method following a homogenous HDL-C assay. oxLDL was measured by ELISA. Results: In HD patients, oxLDL concentration was higher compared to the controls (1.40 ± 0.47 vs. 0.21 ± 0.05 mg/l, p = 0.017) and was significantly associated to total cholesterol (r = 0.480, p = 0.044), LDL-C (r = 0.544, p = 0.019), HDL-C (r = –0.589, p = 0.027) and C-reactive protein (r = 0.578, p = 0.024). Comparing HDL-C subclasses, only HDL2-C was negatively correlated to oxLDL levels (r = –0.565, p = 0.035). Conclusions: In HD patients, high serum levels of oxLDL are associated with low HDL2-C subclass levels. This might suggest that oxidative stress affects the HDL subclass more related to the protecting activity of HDL-C, contributing to atherosclerosis development.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Samouilidou

Karpouza²,

Grapsa³

et al. 2010

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…Interestingly, the overall decreased PC observed in this study was apparently not suffi cient to cause major structural changes in the LDL, as there was no signifi cant change in the size of the LDL particles in CKD. The decrease in PCs observed is in agreement with a previous report on levels of PC in plasma of ESRF patients ( 43 ), and also with the observation that PCs are lost in urine of patients with CKD ( 44 ). The lower levels of STs and CSs in LDL of CKD patients are in agreement with some previous studies ( 17 ).…”

Section: Statistical Analysis Discriminated Control and Ckd Ldl Lipidsupporting

confidence: 93%

Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease

Reis

Rudnitskaya

Chariyavilaskul

et al. 2015

Journal of Lipid Research

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a serious and increasingly common condition ( 1 ). Patients with CKD have a greatly increased risk of CVD, which represents the most common cause of mortality and morbidity in these patients, to the extent that CKD is considered an independent risk factor for CVD ( 2, 3 ). In CKD, many conventional risk factors for CVD are prevalent, including hypertension, dyslipidemia, and insulin resistance. Underlying conditions that are typical of CVD also occur, such as heightened infl ammatory status, oxidative stress, endothelial dysfunction, and arterial stiffness ( 3, 4 ). Consequently, understanding the factors in CKD that could contribute to increased CVD risk is very important.In CVD there is a clearly established link between dyslipidemia (specifi cally hypercholesterolemia and hypertriglyceridemia) and atherosclerosis, an underlying pathology of most CVD ( 5, 6 ). In view of the clear cardiorenal relationship, there has been considerable interest in the possible contribution of hyperlipidemia to CKD-associated CVD ( 7,8 )

show abstract

“…17 However, it contradicts with other studies where decreased levels of the largest HDL2b subclass and increased levels of small HDL3a subclass were separated from plasma of HD patients by polyacrylamide gradient gel electrophoresis 16 or decreased levels of both HDL2-C and HDL3-C were found. 19,20 The above discrepancies could be either the result of different procedures of HDL-C subclass isolation or due to statistical comparison of different number of sample groups. The alteration of HDL-C subclass composition in dialysis patients compared with controls may have clinical relevance in the atherogenesis process in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…14 There is limited evidence concerning the comparison of oxLDL concentration in patients treated with different modes of dialysis, 15 although there are few studies about the comparison of antibodies against oxLDL in dialysis subgroups of patients. Also to our knowledge, the effect of hemodialysis (HD) on distribution of HDL subclasses in serum has been studied recently [16][17][18][19][20] but no data about the effect of peritoneal dialysis (PD) have been reported. This study attempts to look into the comparison of oxLDL levels, lipids, and lipoproteins in patients on HD and PD and in normal controls (NC).…”

Section: Introductionmentioning

confidence: 99%

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

et al. 2011

View full text Add to dashboard Cite

Dyslipoproteinemia and oxidative modification of low-density lipoprotein (oxLDL) contribute to the development of oxidative stress and atherosclerosis in chronic kidney disease (CKD). On the contrary, high-density lipoprotein cholesterol (HDL-C), especially HDL3-C subtype, has protective effect against oxidative damage. There is limited evidence referring HDL-C subclass levels in patients on dialysis. This study was designed to compare lipid abnormalities and oxLDL levels in hemodialysis (HD) and peritoneal dialysis (PD) patients. Serum lipids, HDL subclasses, and oxLDL were measured in 55 patients with CKD-stage 5 (31 patients on HD and 24 patients on PD) and in 21 normal controls (NC). The results showed that in dialysis patients, triglycerides were higher than in controls (p < 0.0001) and HDL-C was significantly lower (p < 0.0001). The HDL2-C subclass concentration did not differ significantly between patients and controls, while HDL3-C was lower in patients (11 ± 0.5 mg/dL) than in NC (23 ± 1, p < 0.0001). oxLDL levels were markedly increased in patients (1.92 ± 0.29 mg/L) compared to NC (0.22 ± 0.05, p < 0.0001). Patients on PD had higher levels of cholesterol (p < 0.001) and apolipoprotein B (p < 0.05) than patients on HD. However, HDL-C, HDL-C subclasses, and oxLDL concentrations did not differ significantly between PD and HD patients. It is concluded that patients with CKD have a nearly 10-fold elevation of oxLDL compared with NC. Patients on PD have differences in the lipid profile compared with patients on HD; however, both modalities seem to possess similar potential to atherosclerosis development.

show abstract

Effects of hemodialysis on serum lipids and phospholipids of end-stage renal failure patients

Cited by 22 publications

References 25 publications

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease

Lipid Abnormalities and Oxidized LDL in Chronic Kidney Disease Patients on Hemodialysis and Peritoneal Dialysis

Contact Info

Product

Resources

About