Effects of hemodialysis on protein-bound calcium

Duncan, P H; Savory, John; Gitelman, Hillel J.

doi:10.1038/ki.1979.36

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…During hemodialysis total cal cium and protein-bound calcium levels increase, probably due to a diffusion of calcium from the dialysis fluid and an enhanced affinity of calcium to the serum proteins result ing from the alkalinizing effect of hemodialysis [5,7,10,14]. Likewise the influence of varying concentrations of cal cium has been studied during hemodialysis, and serum ionized calcium has been reported to decrease with the use of a dialysis fluid containing 1.25 mmol/l of total calcium but to increase with a concentration of 1.87 mmol/l [11],…”

Section: Discussionmentioning

confidence: 99%

Calcium Transfer during Intermittent Peritoneal Dialysis

Andersen¹

1981

Nephron

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Calcium transfer during intermittent peritoneal dialysis (IPD) was studied in four groups of patients with chronic renal failure. Group I dialyzed with a dialysis fluid concentration of 2.16 mmol/l. Group II dialyzed with the same calcium content, but with a hyperosmotic solution. Group III dialyzed with a high calcium concentration, 4.47 mmol/l in dialysis fluid and in group IV the patients dialyzed 5 cycles against a calcium-free solution followed by 5 cycles with normal calcium content. In the first three groups a significant rise in serum total calcium and ionized serum calcium took place. At balance studies a positive net transfer of calcium from dialysis fluid to blood was demonstrated, the largest transfer occurring in group III. High osmolality in dialysis fluid is of no importance for the calcium transfer. In group IV a significant fall in serum total calcium during the first 5 cycles was removed. The loss of albumin to the dialysate did not affect the calcium transfer as well as the changes in serum albumin and pH did not influence the calcium state during IPD.

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Section: Discussionmentioning

confidence: 99%

Calcium Transfer during Intermittent Peritoneal Dialysis

Andersen¹

1981

Nephron

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“…The equilibrium among the differ ent plasma calcium fractions varies with pH, plasma protein concentration and plasma protein binding [13]. An increased concentration of plasma proteins and a rise of blood pH may promote additional calcium binding to serum proteins [14,15]. Whether or not hemodialysis alters the affinity of protein for calcium is still under investigation [14,16].…”

Section: Calcium Kineticsmentioning

confidence: 99%

“…An increased concentration of plasma proteins and a rise of blood pH may promote additional calcium binding to serum proteins [14,15]. Whether or not hemodialysis alters the affinity of protein for calcium is still under investigation [14,16]. Finally, the hematocrit of the patient is likely to affect the amount of transfer of this solute from patient to dialysate or vice versa.…”

Section: Calcium Kineticsmentioning

confidence: 99%

Bicarbonate and Calcium Kinetics in Postdilutional Hemodiafiltration

Memoli

Gazzotti

Russo

et al. 1991

Nephron

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Hemodiafiltration (HDF) is a very effective blood treatment resulting from the coupling of dialysis and hemofiltration and leading to reduction of dialysis time. The aim of this study was to evaluate the balance of bicarbonate and calcium through the filter during postdilutional HDF (with an ultrafiltration flow rate of 70 ml/min) and to verify the effect of ultrafiltration on the kinetics of these two solutes. The study was performed by simultaneously collecting three blood samples (at filter inlet and outlet and after reinfusion) at different ultrafiltration flow rates (12.5–90 ml/min), to measure blood pH, pCO₂, plasma total CO₂ (TCO₂), total calcium, ionized calcium and plasma protein concentration. Plasma bicarbonate concentration was calculated by measuring plasma TCO₂. The results showed an inverse linear relationship between bicarbonate (r: -0.7938; p < 0.001) and calcium (r: -0.8731; p < 0.001) balance and ultrafiltration flow rate. In particular, in postdilutional HDF both bicarbonate and calcium balances through the filter were negative at ultrafiltration flow rates greater than 40 and 55 ml/min, respectively. The negative bicarbonate balance, however, was corrected by reinfusing a substituting solution containing bicarbonate (40 mmol/l). By contrast, the negative calcium balance cannot be corrected by reinfusion and requires a greater calcium concentration in the dialysate and oral calcium supplements.

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