Effects of hemispheric lateralization and site specificity on immune alterations induced by kindled temporal lobe seizures

Goldstein, Kenneth; Bhatt, Rekha; Barton, Beverly E.; Zalcman, Steven S.; Rameshwar, Pranela; Siegel, Allan

doi:10.1016/s0889-1591(02)00024-7

Cited by 23 publications

(16 citation statements)

References 47 publications

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“…Even the weight of the thymus has been found to be significantly modulated by 402 BRAUN lesion side (Renoux, Bizière, Renoux, & Guillaumin, 1980). This crossed dissociation of lesion side on immune function is probably not due to an occult asymmetric effect of unilateral lesions because (1) the dissociation is crossed, and (2) the dissociation reverses sides with long-term potentiation (epileptic-like kindling) of each temporal lobe (Goldstein et al, 2002). Contrary effects have been obtained only in the first few days post lesion (Barneoud, Neveu, Vitiello, & Le Moal, 1988b).…”

Section: Hemispheric Specialisation Of the Immune System In Animals Amentioning

confidence: 90%

Evolution of hemispheric specialisation of antagonistic systems of management of the body's energy resources

Braun¹

2007

Laterality: Asymmetries of Body, Brain and Cognition

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Excellent and rich reviews of lateralised behaviour in animals have recently been published indexing renewed interest in biological theorising about hemispheric specialisation and yielding rich theory. The present review proposes a new account of the evolution of hemispheric specialisation, a primitive system of "management of the body's energy resources". This model is distinct from traditionally evoked cognitive science categories such as verbal/spatial, analytic/holistic, etc., or the current dominant neuroethological model proposing that the key is approach/avoidance behaviour. Specifically, I show that autonomic, immune, psychomotor, motivational, perceptual, and memory systems are similarly and coherently specialised in the brain hemispheres in rodents and man. This energy resource management model, extended to human neuropsychology, is termed here the "psychic tonus" model of hemispheric specialisation.

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Section: Hemispheric Specialisation Of the Immune System In Animals Amentioning

confidence: 90%

Evolution of hemispheric specialisation of antagonistic systems of management of the body's energy resources

Braun¹

2007

Laterality: Asymmetries of Body, Brain and Cognition

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“…The effect of injection of exogenous IL-1β was dependent on the site of application with neurodegeneration observed only in the dentate gyrus of the hippocampus but not in the cortex, substantia nigra or striatum [7]. In the kindling model of temporal lobe seizures, kindling on the left but not the right side induced a hyper-responsive immune state [8]. This is consistent with previous data suggesting that under physiological conditions the right neocortex depresses immune functions whereas the left hemisphere enhances them [9].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: A video–EEG study

Alapirtti

Rinta

Hulkkonen

et al. 2009

Journal of the Neurological Sciences

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“…While RANTES alone has been shown to induce apoptosis through activation of caspase-9, caspase-3, release of cytochrome c and poly(ADP-ribose) polymerase cleavage, there is evidence that IFN-gamma stimulates RANTES which in turn produces apoptosis via stimulation of caspase-3 and caspase-9 [56, 57]. Production of IF-N gamma has been shown to result from Con A-stimulated splenocytes in left side kindled rats with temporal lobe seizures [58]. Therefore, future research is warranted to investigate the complex interactions involving IFN-gamma, RANTES, caspase-3, caspase-9 and their roles in neuronal apoptosis in temporal lobe epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy

et al. 2013

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To identify the upstream signals of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy (TLE), we evaluated by immunohistochemistry and confocal microscopy brain tissues of 13 TLE patients and 5 control patients regarding expression of chemokines and cell-cycle proteins. The chemokine RANTES (CCR5) and other CC-chemokines and apoptotic markers (caspase-3, -8, -9) were expressed in lateral temporal cortical and hippocampal neurons of TLE patients, but not in neurons of control cases. The chemokine RANTES is usually found in cytoplasmic and extracellular locations. However, in TLE neurons, RANTES was displayed in an unusual location, the neuronal nuclei. In addition, the cell-cycle regulatory transcription factor E2F1 was found in an abnormal location in neuronal cytoplasm. The pro-inflammatory enzyme cyclooxygenase-2 and cytokine interleukin-1β were expressed both in neurons of patients suffering from temporal lobe epilepsy and from cerebral trauma. The vessels showed fibrin leakage, perivascular macrophages and expression of IL-6 on endothelial cells. In conclusion, the cytoplasmic effects of E2F1 and nuclear effects of RANTES might have novel roles in neuronal apoptosis of TLE neurons and indicate a need to develop new medical and/or surgical neuroprotective strategies against apoptotic signaling by these molecules. Both RANTES and E2F1 signaling are upstream from caspase activation, thus the antagonists of RANTES and/or E2F1 blockade might be neuroprotective for patients with medically intractable temporal lobe epilepsy. The results have implications for the development of new medical and surgical therapies based on inhibition of chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy.

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Effects of hemispheric lateralization and site specificity on immune alterations induced by kindled temporal lobe seizures

Cited by 23 publications

References 47 publications

Evolution of hemispheric specialisation of antagonistic systems of management of the body's energy resources

Evolution of hemispheric specialisation of antagonistic systems of management of the body's energy resources

Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: A video–EEG study

Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy

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