Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis

Abstract

Background-Lymphocytic gastritis is characterised by an accumulation of lymphocytes in the surface epithelium of the stomach. Lymphocytic gastritis has been linked to coeliac disease and Helicobacter pylori infection. Aims-To determine whether H pylori eradication leads to resolution of the lymphocytic infiltrate and clinical improvement in patients with lymphocytic gastritis, and to determine their HLA status. Methods-The Leeds Dyspepsia Questionnaire (LDQ) was administered to 13 patients with lymphocytic gastritis. H pylori serology, 13C urea breath test (UBT), and upper gastrointestinal endoscopy with sampling of the duodenum, antrum, and corpus were done in all cases and the HLA status was determined. Eleven patients had at least one positive test for H pylori. Patients with lymphocytic gastritis and H pylori infection were treated with a one week course of omeprazole, clarithromycin, and metronidazole. Gastric and duodenal intraepithelial lymphocyte (IEL) counts were performed, along with histological assessment of gastric and duodenal biopsies before and after H pylori eradication. Results-Two months after treatment there was a significant reduction in gastric IEL counts in both antrum and corpus. There was no significant change in duodenal IEL counts before and after eradication. According to the Sydney grading there was significant improvement in corpus inflammation after eradication. The patients histologically H pylori positive before treatment became H pylori negative. Dyspepsia scores also improved significantly after treatment. Conclusions-H pylori eradication treatment in patients with lymphocytic gastritis causes significant improvement in the gastric IEL infiltrate, corpus inflammation, and dyspeptic symptoms. H pylori serology is frequently positive when histology and UBT are negative. Lymphocytic gastritis may represent a specific immune response to H pylori infection. (Gut 1999;45:495-498)

Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by Helicobacter pylori infection

“…Different reports regarding an association between H. pylori eradication and subsequent decreases in duodenal IEL counts have found conflicting results. 32,33 Our results suggest that H. pylori colonisation should not be considered a significant cause of duodenal lymphocytosis, and should not, by any means, preclude the further assessment for the possibility of CD in these patients.…”

Gastritis and Carditis

“…Lymphocytic gastritis in patients with celiac disease is more likely to involve the antrum, whereas corpus-predominant lymphocytic gastritis is more likely to represent Helicobacter infection (87,95). Lymphocytic gastritis due to H. pylori infection may resolve after elimination of the infection (83,88,89).…”

Celiac Disease and Helicobacter Pylori Infection: an Ups and Downs Correlation

“…Some studies described a correlation between Hp infection and the increase of gastric and duodenal IEL without villous atrophy [20,25]. Moreover both studies showed that Hp eradication is associated with a decrease in both gastric and duodenal IEL count, suggesting that duodenal intraepithelial lymphocytosis outside CD may be the result of an immune response to luminal antigens, such as Hp, analogous to the response to gluten in celiac patients.…”

“…Several authors also a correlation with lymphocytic gastritis (LG) which is also the most frequent form of gastritis observed in celiac patients [8][9][10][11]20,21].…”