Effects of He-Ne Laser Irradiation on Fibroblasts Derived from Scar Tissue of Rat Palatal Mucosa.

Tominaga, Reiji

doi:10.5357/koubyou.57.580

Cited by 18 publications

(8 citation statements)

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“…At low doses (e.g., 2 J/cm 2 ) , LLLT stimulates proliferation, while high doses (e.g., 16 J/cm 2 ) are suppressive. 16,17 The same type of dose response is observed both in vivo and in vitro, and occurs with all common LLLT wavelengths. 18 Fibroblast maturation and locomotion through the matrix is also influenced by LLLT, 19 and this in turn m ay contri bute to the higher tensile strengths reported for healed wounds.…”

Section: Effects Of Lllt On Fibroblastsmentioning

confidence: 65%

“…LLLT has been shown to stimulate the production of basic fibroblast growth factor (bFGF), a multifunctional polypeptide which supports fibroblast proliferation and differentiation. Fibroblasts irradiated with low dose LLLT show both increased cell proliferation and enhanced production of bFGF, while high dose LLLT suppresses both parameters, 16,21 indicating a causal relationship between autocrine production of bFGF from fibroblasts and proliferation.…”

Section: Effects Of Lllt On Fibroblastsmentioning

confidence: 99%

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The current status of low level laser therapy in dentistry, Part 1. Soft tissue applications

Walsh

1997

Australian Dental Journal

267

177

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Despite more than 30 years of experience with low level laser therapy (LLLT) or 'biostimulation' in dentistry, concerns remain as to its effectiveness as a treatment modality. Controlled clinical studies have demonstrated that while LLLT is effective for some specific applications, it is not a panacea. This paper provides an outline of the biological basis of LLLT and summarizes the findings of controlled clinical studies of the use of LLLT for specific soft tissue applications in dentistry. Areas of controversy where there is a pressing need for further research are identified.

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Section: Effects Of Lllt On Fibroblastsmentioning

confidence: 65%

Section: Effects Of Lllt On Fibroblastsmentioning

confidence: 99%

The current status of low level laser therapy in dentistry, Part 1. Soft tissue applications

Walsh

1997

Australian Dental Journal

267

177

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“…Wound healing is one of the most studied aspects of low-energy lasers [6]. In studies of fibroblast responses to lasers, increased cell division and increased collagen production have been reported [31,50] as well as stimulation of mitochondrial cytochromes. In gingival tissues, He-Ne laser applications could stimulate DNA synthesis of myofibroblasts, without any degenerative changes, and could transform fibroblasts into myofibroblasts, which may promote wound healing [33,44].…”

Section: Discussionmentioning

confidence: 99%

Low-energy He/Ne laser in the prevention of radiation-induced mucositis

Bensadoun

Franquin

Ciais

et al. 1999

Support Care Cancer

211

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Use of the low-energy helium-neon laser (LEL) appears to be a simple atraumatic technique for the prevention and treatment of mucositis of various origins. Preliminary findings, and significant results obtained for chemotherapy-induced mucositis in a previous phase III study, prompted a randomized multicenter double-blind trial to evaluate LEL in the prevention of acute radiation-induced stomatitis. Irradiation by LEL corresponds to local application of a high-photon-density monochromatic light source. Activation of epithelial healing for LEL-treated surfaces, the most commonly recognized effect, has been confirmed by numerous in vitro studies. The mechanism of action at a molecular and enzymatic level is presently being studied. From September 1994 to March 1998, 30 patients were randomized. Technical specification: 60 mW (25 mW at Reims, 1 patient), He-Ne, wavelength 632.8 nm. The trial was open to patients with carcinoma of the oropharynx, hypopharynx and oral cavity, treated by radiotherapy alone (65 Gy at a rate of 2 Gy/fraction, 5 fractions per week) without prior surgery or concomitant chemotherapy. The malignant tumor had to be located outside the tested laser application areas (9 points): posterior third of the internal surfaces of the cheeks, soft palate and anterior tonsillar pillars. Patients were randomized to LEL or placebo light treatment, starting on the first day of radiotherapy and before each session. The treatment time (t) for each application point was given by the equation : t(s)= energy (J/cm2) x surface (cm2)/Power (W). Objective assessment of the degree of mucositis was recorded weekly by a physician blinded to the type of treatment, using the WHO scale for grading of mucositis and a segmented visual analogue scale for pain evaluation. Protocol feasibility and compliance were excellent. Grade 3 mucositis occured with a frequency of 35.2% without LEL and of 7.6% with LEL (P<0.01). The frequency of "severe pain" (grade 3) was 23.8% without LEL, falling to 1.9% with LEL (P<0.05). Pain relief was significantly reduced throughout the treatment period (weeks 2-7). LEL therapy is capable of reducing the severity and duration of oral mucositis associated with radiation therapy. In addition, there is a tremendous potential for using LEL in combined treatment protocols utilizing concomitant chemotherapy and radiotherapy.

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“…16 J/cm 2 ) it is suppressive. [2324] It affects fibroblast maturation and locomotion,[25] and this in turn may contribute to the higher tensile strengths reported for healed wounds. [26] Low-level laser treatment (LLLT) of gingival fibroblasts in the culture has been shown to induce transformation in myofibroblasts (useful in wound contraction) as early as 24 hours after laser treatment.…”

Section: Soft Tissue Applicationmentioning

confidence: 99%

Laser in dentistry: An innovative tool in modern dental practice

Verma

Maheshwari

Singh

et al. 2012

Natl J Maxillofac Surg

196

113

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The term LASER is an acronym for ‘Light Amplification by the Stimulated Emission of Radiation’. As its first application in dentistry by Miaman, in 1960, the laser has seen various hard and soft tissue applications. In the last two decades, there has been an explosion of research studies in laser application. In hard tissue application, the laser is used for caries prevention, bleaching, restorative removal and curing, cavity preparation, dentinal hypersensitivity, growth modulation and for diagnostic purposes, whereas soft tissue application includes wound healing, removal of hyperplastic tissue to uncovering of impacted or partially erupted tooth, photodynamic therapy for malignancies, photostimulation of herpetic lesion. Use of the laser proved to be an effective tool to increase efficiency, specificity, ease, and cost and comfort of the dental treatment.

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Effects of He-Ne Laser Irradiation on Fibroblasts Derived from Scar Tissue of Rat Palatal Mucosa.

Cited by 18 publications

References 0 publications

The current status of low level laser therapy in dentistry, Part 1. Soft tissue applications

The current status of low level laser therapy in dentistry, Part 1. Soft tissue applications

Low-energy He/Ne laser in the prevention of radiation-induced mucositis

Laser in dentistry: An innovative tool in modern dental practice

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