Effects of hazelnut protein isolate-induced food allergy on the gut microenvironment in a BALB/c mouse model

Chen, Chen; Sang, Ziqing; Xie, Qiang; Xue, Wentong

doi:10.1039/d3fo02324a

Cited by 1 publication

(2 citation statements)

References 74 publications

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“…As shown in Figure G, the rectal temperature of mice in the excitation stage can reflect the severity of allergic reaction . After stimulation, the rectal temperature in the BLG group decreased, while the rectal temperature in the control group fluctuated little.…”

Section: Resultsmentioning

confidence: 94%

“…As shown in Figure 2G, the rectal temperature of mice in the excitation stage can reflect the severity of allergic reaction. 20 After stimulation, the rectal temperature in the BLG group decreased, while the rectal temperature in the control group fluctuated little. After stimulation, the rectal temperature of each sample group fluctuated but the fluctuation range was not as good as that of BLG group mice.…”

Section: ■ Materials and Methodsmentioning

confidence: 91%

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Gut Microbiome-Serum Metabolism Revealed the Allergenicity of Ferulic Acid Combined with Glucose-Modified β-Lactoglobulin

Wang,

Zhang,

Chen

et al. 2024

J. Agric. Food Chem.

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A novel strategy combining ferulic acid and glucose was proposed to reduce β-lactoglobulin (BLG) allergenicity and investigate whether the reduction in allergenicity was associated with gut microbiome and serum metabolism. As a result, the multistructure of BLG changed, and the modified BLG decreased significantly the contents of IgE, IgG, IgG 1 , and mMCP-1 in serum, improved the diversity and structural composition of gut microbiota, and increased the content of short-chain fatty acids (SCFAs) in allergic mice. Meanwhile, allergic mice induced by BLG affected arachidonic acid, tryptophan, and other metabolic pathways in serum, the modified BLG inhibited the production of metabolites in arachidonic acid metabolism pathway and significantly increased tryptophan metabolites, and this contribution helps in reducing BLG allergenicity. Overall, reduced allergenicity of BLG after ferulic acid was combined with glucose modification by regulating gut microbiota, the metabolic pathways of arachidonic acid and tryptophan. The results may offer new thoughts alleviating the allergy risk of allergenic proteins.

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Section: Resultsmentioning

confidence: 94%

Section: ■ Materials and Methodsmentioning

confidence: 91%

Gut Microbiome-Serum Metabolism Revealed the Allergenicity of Ferulic Acid Combined with Glucose-Modified β-Lactoglobulin

Wang,

Zhang,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Effects of hazelnut protein isolate-induced food allergy on the gut microenvironment in a BALB/c mouse model

Abstract: Hazelnuts are reported as one of the nuts that cause severe allergic reactions. However, few systematic studies exist on the changes in the gut microenvironment following hazelnut allergy. This study...

Cited by 1 publication

References 74 publications

Gut Microbiome-Serum Metabolism Revealed the Allergenicity of Ferulic Acid Combined with Glucose-Modified β-Lactoglobulin

Gut Microbiome-Serum Metabolism Revealed the Allergenicity of Ferulic Acid Combined with Glucose-Modified β-Lactoglobulin

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