Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction

Hwang, Hyun Seok; Boluyt, Marvin O.; Converso, Kimber; Russell, Mark W.; Bleske, Barry E.

doi:10.1592/phco.29.6.639

Cited by 15 publications

(12 citation statements)

References 28 publications

(46 reference statements)

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“…There were little effects on the cardiac performance, which may be resulted from LV endocardial FS as endocardial contractility index, a less sensitive performance parameter [41] used in this study. The results are similar to those of many previous studies of hypertrophied rats [10,42,43].…”

Section: Discussionsupporting

confidence: 92%

Exogenous nerve growth factor supplementation elevates myocardial immunoreactivity and attenuates cardiac remodeling in pressure-overload rats

He¹,

Ye²,

Zhou³

et al. 2012

ABBS

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It is postulated that supplementation of exogenous nerve growth factor (NGF) might mediate improvement of the cardiac sympathetic nerve function in heart failure (HF). Local intramuscular injection of NGF near the cardiac sympathetic ganglia could influence the innervation pattern, norepinephrine transporter (NET) gene expression, and improve the cardiac remodeling in experimental HF animals. In this study, we injected NGF into the scalenus medius muscles of Sprague-Dawley rats with abdominal aortic constriction (AC). The nerve innervated pattern, left ventricular morphology, and function following injection in rats with AC were investigated respectively by immunohistochemistry and echocardiography. Levels of mRNA expression of NET, growth associated protein 43 (GAP 43), NGF and its receptors TrkA and p75 NTR , and brain natriuretic peptide (BNP) were measured by realtime polymerase chain reaction. The results showed that myocardial NGF mRNA levels were comparable in rats with AC. Short-term supplementation of exogenous NGF raised the myocardial NGF immunoreactivity, but did not cause hyperinnervation and NET mRNA upregulation in the AC rats. Furthermore, myocardial TrkA mRNA was found to be remarkably decreased and p75 NTR mRNA was increased. Myocardial TrkA downregulation may play a beneficial effect for avoiding the hyperinnervation, and it is reasonable to postulate that p75 NTR can function as an NGF receptor in the absence of TrkA. Interestingly, local NGF administration into the neck muscles near the ganglia could attenuate cardiac remodeling and downregulate BNP mRNA. These results suggest that exogenous NGF can reach the target tissue along the axons anterogradely, and improve the cardiac remodeling.

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Section: Discussionsupporting

confidence: 92%

Exogenous nerve growth factor supplementation elevates myocardial immunoreactivity and attenuates cardiac remodeling in pressure-overload rats

He¹,

Ye²,

Zhou³

et al. 2012

ABBS

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“…The raw conduction (volume) signal is recorded in volts, therefor the predicted EDV is used to convert the peak voltage for each cardiac cycle to the maximum volume and the predicted SV is used to scale the amplitude of the voltage signal. fits (using (1) to literature data from catheter [33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52] and MRI-based measurement modalities [34,35,37,39,40,41,42,44,47,48,49,50,51]. Error bars denote the standard deviation from each study.…”

Section: Volume-conductance Calibrationmentioning

confidence: 99%

Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model

Marquis

Arnold

Dean-Bernhoft

et al. 2018

Mathematical Biosciences

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Mathematical models are essential tools to study how the cardiovascular system maintains homeostasis. The utility of such models is limited by the accuracy of their predictions, which can be determined by uncertainty quantification (UQ). A challenge associated with the use of UQ is that many published methods assume that the underlying model is identifiable (e.g. that a one-to-one mapping exists from the parameter space to the model output). In this study we present a novel workflow to calibrate a lumped-parameter model to left ventricular pressure and volume time series data. Key steps include using (1) literature and available data to determine nominal parameter values; (2) sensitivity analysis and subset selection to determine a set of identifiable parameters; (3) optimization to find a point estimate for identifiable parameters; and (4) frequentist and Bayesian UQ calculations to assess the predictive capability of the model. Our results show that it is possible to determine 5 identifiable model parameters that can be estimated to our experimental data from three rats, and that computed UQ intervals capture the measurement and model error.

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“…Early remodelling is an adaptive response to the increased load of the heart and/or the loss of contractile components in order to maintain pumping capacity. Chronic long‐term overload results in an enlarged left ventricle and progressive deterioration of pump function and impaired diastolic and systolic function of the left ventricle 43, 44. A 3 week treatment with hawthorn extract (WS1442) attenuated systolic dysfunction of the left ventricle and modified cardiac remodelling induced by 1 month of aortic constriction in rats 43…”

Section: Health Effects Of Phenolic Compounds Of Hawthornmentioning

confidence: 99%

Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

Yang¹,

Liu²

2012

J Sci Food Agric

100

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Epicatechin, aglycons and glycosides of B-type oligomeric procyanidins and flavonols, phenolic acids and C-glycosyl flavones are the major groups of phenolic compounds in hawthorn (Crataegus spp). The total content of phenolic compounds is higher in the leaves and flowers than in the fruits. Procyanidins dominate in the fruits, whereas flavonol glycosides and C-glycosyl flavones are most abundant in the leaves. Genotype and developmental/ripening stage have strong impacts. Procyanidin glycosides and C-glycosyl flavones may be chemotaxonomic markers differentiating species and varieties of hawthorn. Future research shall improve the separation, identification and quantification of procyanidins with degree of polymerisation (DP) ≥ 6, procyanidin glycosides, C-glycosyl flavones and some flavonol glycosides. In vitro and animal studies have shown cardioprotective, hypolipidaemic, hypotensive, antioxidant, radical-scavenging and anti-inflammatory potentials of hawthorn extracts, suggesting different phenolic compounds as the major bioactive components. However, the varying and insufficiently defined composition of the extracts investigated, as a result of different raw materials and extraction methods, makes comparison of the studies very difficult. Clinical evidence indicates that some hawthorn extracts may increase the exercise tolerance of patients with congestive heart failure. More clinical studies are needed to establish the effects of hawthorn, especially in healthy humans.

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Effects of Hawthorn on the Progression of Heart Failure in a Rat Model of Aortic Constriction

Abstract: Hawthorn treatment exhibited modest beneficial effects on cardiac remodeling and function during long-term, pressure overload-induced heart failure in rats.

Cited by 15 publications

References 28 publications

Exogenous nerve growth factor supplementation elevates myocardial immunoreactivity and attenuates cardiac remodeling in pressure-overload rats

Exogenous nerve growth factor supplementation elevates myocardial immunoreactivity and attenuates cardiac remodeling in pressure-overload rats

Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model

Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins

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