Effects of Halothane on Children's Electroretinograms

Wongpichedchai, Supachai; Hansen, Ronald M.; Koka, Babu V.; Gudas, Valerie M.; Fulton, Anne B.

doi:10.1016/s0161-6420(92)31810-x

Cited by 32 publications

(12 citation statements)

References 12 publications

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“…The majority of patients, 94 of 114 (82 %), were tested under general anesthesia. Prior studies have shown that this type of light (minimum aveolar concentration B1.0), brief anesthesia does not affect ERG parameters [35]. The remaining 20 patients (18 %) were tested without sedation.…”

Section: Ergmentioning

confidence: 99%

Electroretinographic (ERG) responses in pediatric patients using vigabatrin

et al. 2012

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The antiepileptic drug vigabatrin is known to cause retinal and visual dysfunction, particularly visual field defects, in some patients. Electroretinography (ERG) is used in an attempt to identify adverse effects of vigabatrin (VGB) in patients who are not candidates for conventional perimetry. We report data from 114 pediatric patients taking VGB referred for clinical evaluation; median age at test was 22.9 (2.4 to 266.1) months, and median duration of VGB use was 9.7 (0.3 to 140.7) months. Twenty-seven of them were tested longitudinally (3 to 12 ERG tests). ERG responses to full-field stimuli were recorded in scotopic and photopic conditions, and results were compared to responses from healthy control subjects. We found that abnormalities of photoreceptor and post-receptor ERG responses are frequent in these young patients. The most frequently abnormal scotopic parameter was post-receptor sensitivity, log σ, derived from the b-wave stimulus-response function; the most frequently abnormal photopic parameter was the implicit time of the OFF response (d-wave) to a long (150 ms) flash. Abnormal 30-Hz flicker response amplitude, previously reported to be a predictor of visual field loss, occurred infrequently. For the group as a whole, none of the ERG parameters changed significantly with increasing duration of VGB use. Four of the 27 patients tested longitudinally showed systematic worsening of log σ with duration of VGB use. In a subset of patients who underwent perimetry (N = 39), there was no significant association of any ERG parameter with visual field defects. We cannot determine whether the ERG abnormalities we found were due solely to the effects of VGB. We caution against over-reliance on the ERG to monitor pediatric patients for VGB toxicity and recommend further development of a reliable test of peripheral vision to supplant ERG testing.

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Section: Ergmentioning

confidence: 99%

Electroretinographic (ERG) responses in pediatric patients using vigabatrin

et al. 2012

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“…However, electrodes that contact the eye may not be tolerated well by young children. Although the anxious or unco-operative child can be tested under sedation or anaesthesia [3,4,5,6], these procedures may not be appropriate as a first line of approach [7] and may be discouraged for routine tests because of cost factors and the risk to the patient. Moreover, the effects of anaesthetic agents on the ERG are only partially understood and also it is difficult to obtain the necessary normative data with these protocols.…”

Section: Introductionmentioning

confidence: 99%

Comparison of ERGs recorded with skin and corneal-contact electrodes in normal children and adults

2004

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“…They also found that anesthesia with the combination of nitrous oxide and halogenated anesthetics (halothane or isoflurane) produces a severe impact on the amplitude of the scotopic responses, and significant implicit time prolongation of all electroretinogram components. Other studies did not find a significant effect of sedation with chloral hydrate [5] or anesthesia with halothane [6] on the electroretinogram's responses. However, these effects should be taken into consideration when interpreting electroretinograms in sedated or anesthetized children.…”

Section: Sedationmentioning

confidence: 95%