Effects of Halothane, Enflurane, and Isoflurane on Hypoxic Pulmonary Vasoconstriction in Rat Lungs In Vitro

Marshall, Carol Lynn; Lindgren, L.; Marshall, Bryan E.

doi:10.1097/00000542-198404000-00006

Cited by 108 publications

(43 citation statements)

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“…In a perfused rat lung model in which HPV was stimulated by ventilation with 3% O 2 , the minimal alveolar concentration (MAC) that depressed HPV by 50% for halothane, enflurane, and isoflurane were 0.47, 0.56 and 0.60 MAC units, respectively [68]. During one-lung ventilation, propofol caused less hypoxemia and created lower shunt fractions than the inhalational anesthetics, isoflurane and sevoflurane, suggesting that propofol has less effect on HPV [13].…”

Section: Inhalational Anesthetics Inhibit Hypoxic Pulmonary Vasoconstmentioning

confidence: 99%

An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

Nagendran

Stewart

Hoskinson

et al. 2006

Current Opinion in Anaesthesiology

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Section: Inhalational Anesthetics Inhibit Hypoxic Pulmonary Vasoconstmentioning

confidence: 99%

An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

Nagendran

Stewart

Hoskinson

et al. 2006

Current Opinion in Anaesthesiology

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“…Studies on isolated perfused lungs showed an inhibition of HPV by inhaled agents. 3,4,8 Conversely, experiments with intact mammals showed either an inhibition 23 or no significant effect. 6,9,24 Associated iv anesthetics This experiment required general anesthesia and mechanical ventilation.…”

Section: Desflurane In Hypoxiamentioning

confidence: 94%

“…2 In vitro studies have demonstrated that halothane, enflurane, isoflurane and sevoflurane inhibit hypoxic pulmonary vasoconstriction (HPV). 3,4 However halogenated agents seem to be less effective pulmonary vasodilators in in vivo lung lobes. [5][6][7] Desflurane is a recently introduced inhalational anesthetic.…”

Section: [La Vasoconstriction Pulmonaire Hypoxique N'est Pas Inhibée mentioning

confidence: 99%

Sub-MAC concentrations of desflurane do not inhibit hypoxic pulmonary vasoconstriction in anesthetized piglets

et al. 2001

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P Pu ur rp po os se e: : In vitro, halogenated agents reduce the pulmonary vasoconstrictor response to alveolar hypoxia in isolated perfused lungs. However, studies in intact animals have been less convincing. The aim of the present study was to assess the effect of sub-MAC concentrations of desflurane on hypoxic pulmonary vasoconstriction (HPV) in anesthetized piglets using the pressure/cardiac output relationship (P/Q).M Me et th ho od ds s: : Eleven large white piglets were anesthetized and ventilated mechanically, alternatively in hyperoxia (FIO 2 =0.4) and in hypoxia (FIO 2 =0.12). Multipoint plots of pulmonary arterial pressure (PAP), or differences between PAP and left atrial pressure (LAP) against Q were generated by gradual inflation of a balloon advanced into the inferior vena cava. P/Q relationships were established in hyperoxia and in hypoxia at baseline, and then with gradual concentrations of desflurane.R Re es su ul lt ts s: : In hypoxia, pressure gradients (PAP-LAP) increased significantly at every level of Q, demonstrating active pulmonary vasoconstriction. Desflurane did not affect these P/Q relationships either in hyperoxia, or in hypoxia, when compared with baseline.C Co on nc cl lu us si io on n: : Desflurane at a clinically relevant dose has no significant effect on HPV in anesthetized piglets.Objectif: La plupart des agents halogénés dont le desflurane inhibent la vasoconstriction pulmonaire hypoxique (VPH) sur le poumon isolé de mammifère. Le but de cette étude est d évaluer les effets de cet halogéné sur la VPH du porc entier anesthésié, au moyen de la relation pression vasculaire trans-pulmonaire (PAP-POG)/débit cardiaque (Q). Résultats: En hypoxie, la pente des relations pression/débit a augmenté de façon significative, et ce pour chaque variation de Q mettant ainsi en évidence un phénomène de VPH active. Le desflurane n a pas eu d effet significatif sur les relations (PAP-POG)/Q en hyperoxie, ni en hypoxie. Matériel et méthodes: Conclusion:Contrairement aux études in vitro, le desflurane n inhibe pas, de façon significative la VPH du porc entier anesthésié.

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“…Although work published in the 1980s was able to make a clear association between the blunting of hypoxic pulmonary vasoconstriction (HPV) and inhalational anesthetics in rat lungs [20], a recent meta-analysis by Bassi et al [21 ] was unable to demonstrate a benefit of one technique over the other in humans. A study published by De Conno et al [22 ] showed that patients receiving the volatile anesthetic sevoflurane during OLV expressed lower levels of inflammatory mediators than patients receiving a target controlled infusion of propofol.…”

Section: Anesthetic Implicationsmentioning

confidence: 99%

An update on anesthesia for thoracoscopic surgery

Fischer

Cohen

2010

Current Opinion in Anaesthesiology

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Effects of Halothane, Enflurane, and Isoflurane on Hypoxic Pulmonary Vasoconstriction in Rat Lungs In Vitro

Cited by 108 publications

References 0 publications

An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

Sub-MAC concentrations of desflurane do not inhibit hypoxic pulmonary vasoconstriction in anesthetized piglets

An update on anesthesia for thoracoscopic surgery

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