1996
DOI: 10.1016/0024-3205(96)00104-x
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Effects of halothane and isoflurane on rat ventricular action potentials recorded in situ

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Cited by 7 publications
(3 citation statements)
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“…However, the effects have been extremely inhomogeneous. Hayes et al (14) reported that halothane prolonged the APD measured at 50% repolarization (APD 50 ), whereas others found a shortening of APD 50 by halothane (11,15,16). Similar varied results were shown for isoflurane (11,13) and sevoflurane (17,18).…”
Section: Basic Electrophysiology Of the Cardiomyocyte And Arrhythmiassupporting
confidence: 71%
“…However, the effects have been extremely inhomogeneous. Hayes et al (14) reported that halothane prolonged the APD measured at 50% repolarization (APD 50 ), whereas others found a shortening of APD 50 by halothane (11,15,16). Similar varied results were shown for isoflurane (11,13) and sevoflurane (17,18).…”
Section: Basic Electrophysiology Of the Cardiomyocyte And Arrhythmiassupporting
confidence: 71%
“…Studies implicate halocarbons in alterations of a number of ion channels, and these changes may contribute to their arrhythmic effect. Halocarbon effects include activation of hyperpolarizing, background potassium channels [37,38], reduction of gap junction conductance between cells [39], alterations of voltagegated calcium channel activity [40], increases in calcium release from the sarcoplasmic reticulum [41][42][43][44] and depression of the sodium current [36,[45][46][47].…”
Section: Halocarbons and Arrhythmic Riskmentioning
confidence: 99%
“…As such the overall effect of halothane on action potential configuration will depend on the relative density of expression of the various halothane‐sensitive ion channels between species and tissues. For example, exposure to halothane led to an overall reduction of action potential duration in rat ventricular myocytes ( Harrison et al ., 1999 ; Hayes et al ., 1996 ), guinea‐pig papillary muscles ( Ozaki et al ., 1989 ), canine Purkinje fibres ( Polic et al ., 1991 ) and human atrial fibres ( Luk et al ., 1988 ) which is consistent with a dominant inhibitory action of halothane on I Ca in these preparations. However, ( Bosnjak & Kampine, 1986 ) reported in cat papillary muscles that halothane induced a considerable negative inotropic effect but had little effect on the duration of action potentials.…”
Section: Discussionmentioning
confidence: 99%