Effects of haloperidol on human plasma magnesium

Jabotinsky-Rubin, K; Durst, Ronen; Levitin, L.A.; Moscovich, Daniel G.; Silver, Helayne M.; Lerner, Jodi P.; Praag, Herman van; Gardner, Eliot L.

doi:10.1016/0022-3956(93)90003-k

Cited by 19 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, most studies did not consider major confounders such as age, obesity, psychotropic medication, and other chronic medical diseases. Various psychotropic medications could affect blood Ca and Mg levels, including antidepressants [9,11], neuroleptics [28,29], and lithium [14,30]. In the present study, the study participants had no history of psychiatric disorders or psychotropic medications and data analyses were performed with adjustments for significant confounders.…”

Section: Discussionmentioning

confidence: 99%

Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders

Jung

Ock

Chung

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

Several lines of evidence from previous studies suggest that Calcium (Ca) and Magnesium (Mg) may be involved in intracellular and interneuronal processes associated with affective disorders. However, there have been inconsistent results on the effect of Ca and Mg on depressive mood disorder. This cross-sectional study was conducted to determine whether serum Ca and Mg levels, as well as serum Ca/Mg ratio, are associated with mental health in relatively healthy, adult women without psychiatric disorders. One hundred and twelve adult women were recruited from the outpatient clinic in a university hospital setting. Serum Ca and Mg levels were measured and indicators of mental health such as depression, anxiety, and stress were evaluated using two validated questionnaires; the Hospital Anxiety Depression Scale and the Modified Brief Encounter Psychosocial Instrument Stress Scale. After categorizing the serum Ca and Mg levels, and the Ca/Mg ratio into tertiles, the mean scores on each mental health scale were compared using analysis of covariance. The risk of depressive mood disorder according to the tertiles of serum Mg level and serum Ca/Mg ratio was assessed using logistic regression analysis. Women in the middle tertile of serum Ca/Mg ratio had significantly lower scores on depression and stress scales (p = 0.004 and p = 0.007, respectively) and a lower odds ratio (OR) for the risk of depressive mood disorder (OR = 0.31, CI(95%) 0.10-0.93) than those in the highest tertile. The OR for the risk of depressive mood disorder was higher in women in the lowest tertile of serum Mg than in those in the highest tertile (OR = 3.92, CI(95%) 1.11-13.83). Serum Mg level and serum Ca/Mg ratio may be involved in the mechanism for the progression of depressive mood or stress perception in relatively healthy, adult women.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders

Jung

Ock

Chung

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…It seems that serum calcium levels rise during switch into catatonic schizophrenia [3] or from catatonic to agitated schizophrenia [4], No changes in serum Ca levels were found between drug-free chronic [3] and first-time admis sion [5] schizophrenics versus controls [5], Neuroleptics might cause a decrease of serum Ca levels, as was found in some studies [3,6], but not in others [7], Reduction of bone mineralization and increase of urinary Ca has been observed in chronic schizophrenics [8,9], There is no clear trend for CSF Ca of schizophrenics [10][11][12], and post mortem brain Ca levels of such patients are not dif ferent from controls [13]. It also seems that Ca channel blockers are not beneficial in schizophrenia although fur ther studies may prove otherwise [14,15].…”

mentioning

confidence: 88%

“…There is no consistent trend of serum Mg levels in schizophrenia [3,4,16,17]. It seems that neuroleptic treatment may relatively decrease Mg serum levels [3][4][5][6][7], CSF Mg shows no consistent trend [10,11], and it seems postmortem Mg brain levels are not different from con trols [13].Beside the clear tendency of neuroleptics to lower serum Mg, other data appear controversial. Some of the conflicting data may be attributed to the fact that in some studies the patients were neuroleptic-free for various lengths of time, in others they were treated, and yet in others both types were included.…”

mentioning

confidence: 96%

Serum and Cerebrospinal Levels of Calcium and Magnesium in Acute versus Remitted Schizophrenic Patients

et al. 1996

View full text Add to dashboard Cite

show abstract

“…One should nevertheless notice that in contrast to our study, the patients in the trial of Linder et al [7] and the controls of Young et al [2] were all medicated. Various psychotropic medications are known to affect serum/plasma Ca and Mg levels, including neuroleptics [37,38], antidepressants [9,23] and lithium [6,7].…”

Section: Discussionmentioning

confidence: 99%

High Serum and Cerebrospinal Fluid Ca/Mg Ratio in Recently Hospitalized Acutely Depressed Patients

et al. 1999

View full text Add to dashboard Cite

Calcium (Ca) and magnesium (Mg) are involved in many processes related to depression. Evaluations of serum and plasma Ca and Mg levels in depressive disorders do not show consistent results. The few studies that examined their cerebrospinal fluid (CSF) levels tended to find no differences between depressed patients and controls. Because both hypercalcemia and hypomagnesemia are associated with depression, and as Mg may function as a Ca antagonist, it is suggested that the relationship between these cations could be different in depressed patients and controls. We examined CSF and serum Ca and Mg in acutely depressed patients diagnosed as having major depressive disorder or being in a depressive episode of bipolar disorder. Controls were subjects undergoing lumbar puncture as part of an evaluation for headache or suspected meningitis and found to demonstrate no physical or mental disorder. Serum and CSF Ca/Mg ratios were found to be elevated in the depressed patients compared with the controls. A retrospective analysis of previous trials assessing serum/plasma or CSF Ca and Mg does not seem to refute the findings of this study. We further discuss our findings in their relation to the acuteness of the depressive disorders.

show abstract

Effects of haloperidol on human plasma magnesium

Cited by 19 publications

References 16 publications

Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders

Associations of Serum Ca and Mg Levels with Mental Health in Adult Women Without Psychiatric Disorders

Serum and Cerebrospinal Levels of Calcium and Magnesium in Acute versus Remitted Schizophrenic Patients

High Serum and Cerebrospinal Fluid Ca/Mg Ratio in Recently Hospitalized Acutely Depressed Patients

Contact Info

Product

Resources

About