Effects of haloperidol on a run-climb-run behavioral task: Distance climbed does not alter within-session decrements.

Fowler, Stephen C.; Senyuz, Levent

doi:10.1037/0735-7044.107.4.651

Cited by 4 publications

(2 citation statements)

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“…Within-session response decrements on lever-pressing for hypothalamic and ventral tegmental area ICSS were later reported for other typical APDs such as haloperidol, metoclopramide (6) and raclopride (7). Numerous investigations carried out in operant motivated behaviors, other than ICSS, have also demonstrated the within-session effect of neuroleptics or typical APDs (7)(8)(9)(10)(11)(12)(13). Although at present there is no unanimous conclusion (14)(15)(16), the particular temporal pattern exhibited by neuroleptics has been interpreted mainly from two points of view, namely as a motivational/incentive deficit (6,11,17) or an impairment of motor function due to dopaminergic blockade (18,19).…”

Section: Introductionmentioning

confidence: 92%

Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex

H²,

Jm³

2005

Front Biosci

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It has been described that "typical" antipsychotic drugs (APDs) induce characteristic within-session response decrements in operant behaviors, including intracranial self-stimulation (ICSS). In contrast, recent reports have shown that in food operant behavior, clozapine and a number of "atypical" APDs do not give rise to within-session effects. However, to elucidate whether or not this is a common property of atypical APDs, their effects on other operant models need to be studied. To address this question we investigated the temporal pattern of ICSS responding, after systemic administration of five atypical APDs and the typical antipsychotic, haloperidol. Rats were trained to lever press for electrical stimulation at the medial prefrontal cortex (mPFC), and response rates were recorded during each 3-min period of the 15-min session. Significant within-session response decrements on mPFC ICSS were observed with haloperidol, risperidone, sertindole and olanzapine but not with clozapine or ziprasidone. The magnitude of within-session decline produced by the APDs tested was positively correlated with their affinity for dopamine D2 receptors. The results show for the first time that atypical APDs are capable to induce within-session decrements on ICSS behavior, and suggest that this particular temporal pattern of responding is not exclusively characteristic of typical APDs. The results are also consistent with the hypothesis that the ability of APDs to induce greater within-session effects may be related, in part, to potent D2 antagonism.

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Section: Introductionmentioning

confidence: 92%

Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex

H²,

Jm³

2005

Front Biosci

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“…Using this lick task, we have previously shown that systemic injections of dopamine-blocking drugs such as haloperidol, clozapine, and olanzapine decrease tongue force, number of licks, and lick rhythm in untreated adult rats (Das & Fowler, 1996a, 1996b; Fowler & Mortell, 1992; Fowler & Wang, 1998). Within-session decrements in response rate have been documented after systemic injection of haloperidol (Das & Fowler, 1996b; Fowler & Senyuz, 1993; Liao & Fowler, 1990) but not clozapine (Das & Fowler, 1996a). It has been suggested that these within-session response decrements produced by neuroleptics may be manifestations of the Parkinsonism induced by such drugs (e.g., Fowler, 1990).…”

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confidence: 99%

Effects of unilateral striatal dopamine depletion on tongue force and rhythm during licking in rats.

Skitek¹,

Fowler²,

Tessel³

1999

Behavioral Neuroscience

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To quantitatively assess the orolingual dysfunctions produced by unilateral striatal dopamine depletions, rats first received 6-hydroxydopamine injections into the nigrostriatal bundle and were then trained to lap water from a force-sensing disk in 2-min sessions. Compared with controls and rats with moderate (<75%) dopamine depletions, subjects with substantial (>75%) dopamine depletions showed decreases in number of licks, lick rhythm, and lick peak force. Rats with substantial lesions were also impaired in making initial, within-session adjustments in lick peak force but not in lick rhythm. The results confirm the presence of Parkinson-like deficits in tongue dynamics during consummatory licking behavior in rats. The methods used here should prove useful in providing quantitative measures of the efficacy of experimental therapies in this rodent model of Parkinson's disease.

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Unlike haloperidol, clozapine slows and dampens rats' forelimb force oscillations and decreases force output in a press-while-licking behavioral task

1994

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In order to detect putative differences in the behavioral effects of clozapine and haloperidol, rats were trained to use a single forelimb to exert continuous pressure on a force-sensing operandum. Behavior was maintained by presenting a water-filled dipper for consumption only as long as the force remained above a specified level (the water fountain task). Effects of clozapine (2.0, 4.0, 8.0 mg/kg) and haloperidol (0.02, 0.04, 0.08, 0.12 mg/kg) on the forelimb force oscillations manifested during the operandum pressing episodes were analyzed with power spectral analysis and other quantitative methods. All rats exhibited force oscillations with a fundamental frequency near 7 Hz. Clozapine shifted the frequency to lower values (i.e., oscillation slowing), while haloperidol shifted oscilations to slightly higher frequencies. Moreover, clozapine reduced power in the region of the spectrum above 5 Hz. In contrast, haloperidol tended to increase power in these regions. Time domain analyses of the force-time waveforms indicated that haloperidol increased force emission during the hold phase of the forelimb response, and clozapine decreased this measure. The results are congruent with the high extrapyramidal side effects of haloperidol and the lack of such effects of clozapine in the clinic. In addition, clozapine may have antitremor effects in rats as it does in humans.

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Effects of haloperidol on a run-climb-run behavioral task: Distance climbed does not alter within-session decrements.

Cited by 4 publications

References 41 publications

Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex

Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex

Effects of unilateral striatal dopamine depletion on tongue force and rhythm during licking in rats.

Unlike haloperidol, clozapine slows and dampens rats' forelimb force oscillations and decreases force output in a press-while-licking behavioral task

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