Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection

Zhang, Yimin; Cheng, Yujia; Zhao, Weichao; Song, Fengmei; Cao, Yi

doi:10.1007/s12012-024-09844-7

Cardiovasc Toxicol

2024

DOI: 10.1007/s12012-024-09844-7

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Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection

Yimin Zhang,

Yujia Cheng,

Weichao Zhao

et al.

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Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Wang,

Zhou,

et al. 2024

J of Applied Toxicology

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Food contaminates, such as insecticide, may influence the toxicity of nanoparticles (NPs) to intestine. The present study investigated the combined toxicity of TiO2 NPs and fipronil to male mouse intestine. Juvenile mice (8 weeks) were orally exposed to 5.74 mg/kg TiO2 NPs, 2.5 mg/kg fipronil, or both, once a day, for 5 days. We found that both TiO2 NPs and fipronil induced some pathological changes in intestines, accompanying with defective autophagy, but these effects were not obviously enhanced after TiO2 NP and fipronil co‐exposure. Fipronil promoted Ti accumulation but induced minimal impact on other trace elements in TiO2 NP‐exposed intestines. Metabolomics data revealed that the exposure altered metabolite profiles in mouse intestines, and two KEGG pathways, namely, ascorbate and aldarate metabolism (mmu00053) and glutathione metabolism (mmu00480), were only statistically significantly changed after TiO2 NP and fipronil co‐exposure. Five metabolites, including 2‐deoxy‐D‐erythro‐pentofuranose 5‐phosphate, 5alpha‐cholestanol, beta‐D‐glucopyranuronic acid, elaidic acid, and isopentadecanoic acid, and maltotriose, were more significantly up‐regulated after the co‐exposure, whereas trisaccharide and xylonolactone were only significantly down‐regulated by the co‐exposure. We concluded that fipronil had minimal impact to enhance the toxicity of TiO2 NPs to mouse intestines but altered metabolite profiles.

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Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Wang,

Zhou,

et al. 2024

J of Applied Toxicology

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Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection

Cited by 1 publication

References 66 publications

Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

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Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection

Cited by 1 publication

References 66 publications

Influences of TiO2 nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Influences of TiO2 nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

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Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines