Effects of Haemodialysis on Pulmonary Clearance of Tc-99m Diethylene Triamine Pentaacetate (DTPA)

Yeniçerioğlu, Yavuz; Sahin, Samil; Capa, G; Abadoğlu, Öznur; Camsar, T.; Altan, Rüya; Başar, M. Murad; Durak, Hatice; Uçan, Eyüp Sabri

doi:10.1080/003655900750016751

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Others report normal lung epithelial permeability in CRF [32] and no change in permeability after HD [19].…”

Section: Lung Function In Patients With Chronic Renal Failurementioning

confidence: 93%

“…Furthermore increases in lung vascular permeability synchronous to leukopenia and hypoxemia were demonstrated during the early stage of haemodialysis with cuprophane membrane [58], although data on this subject are conflicting [19,30,59].…”

Section: Table 1 Mechanisms Proposed For Dialysis-induced Hypoxemiamentioning

confidence: 96%

“…Although bronchial hyperreactivity has occasionally been reported in some patients it is probably unrelated to CRF and of dubious clinical significance [19]. Even in CRF patients with reduced FEV 1 bronchial response to histanine or metacholine was normal and no change was observed with dialysis [20,21].…”

Section: Lung Function In Patients With Chronic Renal Failurementioning

confidence: 99%

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Disorders of Respiration and Sleep-Disordered Breathing in Patients with Chronic Renal Failure

Μάρκου¹,

Αθανασίου²,

Hroni³

et al. 2006

CRMR

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Chronic renal failure may be associated with a wide spectrum of respiratory disorders, varying from relatively minor derangements in pulmonary function testing, to frank pulmonary edema. Although complications like uremic lung are becoming increasingly rare in these patients with timely initiation of dialysis, dialysis itself can also exert a transient deleterious influence on gas exchange. Moreover, patients with chronic renal failure often exhibit disorders of the chemical control of breathing that probably contribute to sleep-disordered breathing. Sleep -disordered breathing is a common problem in patients with chronic renal failure, with a reported prevalence possibly exceeding 70% for end-stage renal disease. Sleep disorders, have a serious impact in the quality of life in chronic renal failure, and are probably associated with increased morbidity and mortality. The role of polysomnography and of active intervention in sleep disorders in these patients needs to be further elucidated.

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“…Others report normal lung epithelial permeability in CRF [32] and no change in permeability after HD [19].…”

Section: Lung Function In Patients With Chronic Renal Failurementioning

confidence: 93%

Section: Table 1 Mechanisms Proposed For Dialysis-induced Hypoxemiamentioning

confidence: 96%

Section: Lung Function In Patients With Chronic Renal Failurementioning

confidence: 99%

See 1 more Smart Citation

Disorders of Respiration and Sleep-Disordered Breathing in Patients with Chronic Renal Failure

Μάρκου¹,

Αθανασίου²,

Hroni³

et al. 2006

CRMR

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Pulmonary diffusing capacity in chronic dialysis patients

Herrero¹,

Álvarez-Sala²,

Coronel³

et al. 2002

Respiratory Medicine

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Patients with end-stage renal disease treated by hemodialysis with bioincompatible membranes are exposed during the dialysis period to acute effects on lung microcirculation, which may result in pulmonary fibrosis and diffusion defects in long-standing dialysis. To investigate the occurrence of these possible chronic pulmonary alterations, we determined lung function in patients with chronic renal failure not undergoing hemodialysis and in patients who had been receiving regular hemodialysis both for short and long periods of time. Forty-three patients divided into three groups were studied: 17 patients before dialysis with a mean (SD) creatinine clearance of 14.1 (6.8) ml/min 11.73 m2, 10 patients receiving regular hemodialysis for a period of less than 12 months (mean 6.4 +/- 3.5 months), and 16 patients receiving regular hemodialysis for more than 5 years (mean 8.3 +/- 3.6 years). First-use bioincompatible cellulosic dialysis membranes were used in all the cases. The following parameters were recorded: forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), total lung capacity (TLC), residual volume (RV), carbon monoxide transfer factor (TLCO), accessible lung volume (VA), carbon monoxide transfer factor/accessible lung volume (KCO- that is, TLCO/VA), and arterial blood gases. Patients receiving regular hemodialysis for more than 5 years showed significantly lower values of TLCO and KCO than patients before dialysis and patients receiving regular hemodialysis for less than 12 months. Seventy-five percent of patients on long-term hemodialysis had markedly reduced TLCO or KCO values (below 80% of the reference value) as compared with 17% of patients before dialysis and 10% of patients dialyzed for less than 12 months (P < 0.001). Differences among groups for the remaining parameters were not observed. In conclusion, patients undergoing long-term regular hemodialysis with a bioincompatible membrane showed a selective reduction in pulmonary diffusing capacity possibly due to chronic pulmonary fibrosis.

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Evaluating the changes in alveolar permeability and lung ventilation in patients with chronic renal failure after haemodialysis using 99mTc-DTPA radioaerosol inhalation lung scan

Kao¹,

Shiau

Tsai³

et al. 2003

Nuclear Medicine Communications

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Hypoxaemia occurring in patients with chronic renal failure (CRF) during haemodialysis (HD) has long been known. Several mechanisms of pathogenesis have been proposed. Before and after regular HD, lung ventilation (LV) and alveolar permeability (AP) were measured in 24 male patients with CRF (age, 61-75 years). LV and AP were determined by 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scan (99mTc-DTPA lung scan). The LV images were visually interpreted according to established criteria, including the presence or absence of an inhomogeneous distribution, inverted base to apex gradient and segmental hypoventilation. The degree of AP in the total right lung was presented as the clearance rate (K; %.min-1) of the time-activity curve from dynamic total right lung images. Ten male normal controls (age, 62-76 years) were enrolled in the study for comparison. Ten of 24 (42%) cases showed an inhomogeneous distribution and eight of 24 (33%) cases showed hypoventilation on equilibrium LV images. After regular HD for 5 h, no significant changes in the LV images were found. Before HD, the CRF patient group (K=1.14+/-0.36%.min-1) had a significantly faster clearance rate than that of normal controls (0.75+/-0.14%.min-1, P<0.05). Moreover, the clearance rate after HD was significantly slower (0.87+/-0.15%.min-1, P<0.05) than that before HD. CRF can predispose patients to LV change and AP damage. After HD, the damage to AP is significantly improved. However, after HD, the change in LV is not significant.

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Effects of Haemodialysis on Pulmonary Clearance of Tc-99m Diethylene Triamine Pentaacetate (DTPA)

Abstract: Since we observed no hypoxaemia following haemodialysis, we cannot comment as to whether the changes in pulmonary clearance play a role in the pathogenesis of haemodialysis-associated hypoxaemia. In order to reach reliable conclusions, additional studies are needed.

Cited by 3 publications

References 11 publications

Disorders of Respiration and Sleep-Disordered Breathing in Patients with Chronic Renal Failure

Disorders of Respiration and Sleep-Disordered Breathing in Patients with Chronic Renal Failure

Pulmonary diffusing capacity in chronic dialysis patients

Evaluating the changes in alveolar permeability and lung ventilation in patients with chronic renal failure after haemodialysis using 99mTc-DTPA radioaerosol inhalation lung scan

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