Effects of gut microbiota on atherosclerosis through hydrogen sulfide

Gui, Dan-Dan; Luo, Wen; Yan, Bin-Jie; Zhong, Ren; Tang, Zhi‐Han; Liu, Lu‐Shan; Zhang, Jifeng; Jiang, Zhi‐Sheng

doi:10.1016/j.ejphar.2021.173916

Cited by 23 publications

(15 citation statements)

References 108 publications

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“…kidney, lung, gastrointestinal system, cardiovascular system) and – perhaps most importantly for the purpose of the current article – various immune cells [ 12 , 195 ]. Moreover, part of the intestinal microbiome consists of H 2 S-producing bacteria, which produce H 2 S by several different enzymes, including a bacterial CBS-equivalent [ [196] , [197] , [198] , [199] ]; although much of the H 2 S generated in the intestinal system becomes neutralized by the intestinal epithelial cells, some of it crosses into the circulation and contributes to the systemic H 2 S levels [ 199 , 200 ]. Thus, cancer cells – in addition to their internally generated H 2 S – are also exposed to “external” H 2 S – produced by various cell types in the cancer microenvironment and/or delivered to them via the blood supply – which may, in turn, regulate their function via a variety of mechanisms.…”

Section: Potential Roles Of Host Cbs In Cancermentioning

confidence: 99%

“…From the standpoint of intestinal carcinogenesis, there are multiple lines of emerging data that a dysregulation of H 2 S homeostasis in the intestinal microbiome may contribute to the pathogenesis of colitis, which, in turn, may contribute to the pathogenesis of intestinal polyp formation and carcinogenesis. This field of research is covered in recent review articles [ [198] , [199] , [200] , [201] , [202] ]. As far as the host (mammalian) CBS and carcinogenesis goes, the body of literature is minimal.…”

Section: Potential Roles Of Host Cbs In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Emerging roles of cystathionine β-synthase in various forms of cancer

Ascenção¹,

Szabó²

2022

Redox Biology

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Section: Potential Roles Of Host Cbs In Cancermentioning

confidence: 99%

Section: Potential Roles Of Host Cbs In Cancermentioning

confidence: 99%

Emerging roles of cystathionine β-synthase in various forms of cancer

Ascenção¹,

Szabó²

2022

Redox Biology

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“…Endotelyum kaynaklı H2S sentezinde CSE enziminin primer enzim olduğu kabul edilmekte ve H2S'in ağırlıklı olarak CSE tarafından katalizlendiği bilinmektedir 6,59,60 . H2S'in vasküler dokuda, kan basıncı ve vasküler tonusun düzenlenmesi, aterojenezin inhibisyonu, düz kas hücre proliferasyonunun önlenmesi, sitoprotektif etki ve kardiyovasküler fonksiyonlarda önemli rollere sahip olan fizyolojik bir regülatör olduğu bilinmektedir [10][11][12]21,61,62 . H2S'in direkt olarak damar düz kasında vazodilatasyon yaptığı ve bazal tonusu modüle ettiği gösterilmiştir 63,64 .…”

Section: Hidrojen Sülfür Ve Kardiyovasküler Sistemdeki Rolüunclassified

“…Her dokuda farklı konsantrasyonlarda bulunduğu bilinen H2S'in insan plazmasında 50 μM düzeyinde varlığı tespit edilmiştir 9 . H2S'in antiinflamatuvar, antioksidan, sitoprotektif, hücre otofajı ve apoptoz olaylarının regülasyonu gibi rolleri çeşitli dokularda kanıtlanmıştır [10][11][12] . Vasküler dokularda vazodilatör etkileriyle kan basıncı regülasyonu, düz kas hücre proliferasyonunun önlenmesi, beyin dokusunda nöroprotektif ve nöromodülatör etki, gastrik motiliteyi düzenlenleyici, midede protektif ve antispazmotik etki; ürogenital sistem organlarında konsantrasyona bağlı kasılma ya da gevşeme yanıtları oluşturma ve bronşlarda gevşetici etki ile havayolu tonusunu düzenleme gibi birçok fizyolojik rolü açıklanmıştır [13][14][15][16][17][18] .…”

Section: Introductionunclassified

Contribution of Hydrogen Sulfide to Physiological and Pathological Events and Clinical Use

GÖNBE

Aydinoglu

Ogulener

2022

Arşiv Kaynak Tarama Dergisi

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Hydrogen sulfide (H2S), synthesized by enzymatic or non-enzymatic means, is a third gas neurotransmitter similar to nitric oxide (NO) and carbon monoxide (CO). Enzymes responsible for their synthesis in the body are expressed in various tissues. H2S has many physiological effects such as anti-inflammatory, antiapoptotic, neuroprotective, gastroprotective, antispasmodic, cytoprotective antioxidant, a bronchodilator, blood pressure regulation. Also, it is known that H2S has a role in various pathological conditions such as hypertension, atherosclerosis, depression, asthma, chronic obstructive pulmonary disease (COPD), ulcer, erectile dysfunction, Alzheimer's, and Parkinson's disease. Considering its potential importance in physiopathological conditions, various drugs have been developed in combination with H2S-releasing aspirin and naproxen. In this context, some drugs with anti-inflammatory, analgesic, antioxidant, cytoprotective, and cardioprotective effects have been developed. ATB-346, GIC-1001, NBS-1120, SG-1002, AP-39, and MZe76 are among the candidate drugs. Phase studies of S-zofenopril have been completed. The realization of preclinical and clinical studies on the L-cysteine/H2S pathway is important physiologically, pathologically, and therapeutically, and the development of new drugs in this direction is considered to be promising for treatment approaches.

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“…We also discuss how they affect mitochondrial bioenergetics. For a detailed description of the effects of these metabolites on membrane channels and receptors involved in the regulation of energy and vascular homeostasis, please refer to previous reviews [17,[22][23][24][25][26].…”

Section: Microbiota Metabolites As Energy Substrates and Biological Mediatorsmentioning

confidence: 99%

The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health

et al. 2021

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Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, to thrive, gut bacteria exploit nutrients digested by the host. On the other hand, the host utilizes numerous products of gut bacteria metabolism as a substrate for ATP production in the colon. Finally, bacterial metabolites seep from the gut into the bloodstream and interfere with the host’s cellular bioenergetics machinery. Notably, there is an association between alterations in microbiota composition and the development of metabolic diseases and their cardiovascular complications. Some metabolites, like short-chain fatty acids and trimethylamine, are considered markers of cardiometabolic health. Others, like hydrogen sulfide and nitrite, demonstrate antihypertensive properties. Scientific databases were searched for pre-clinical and clinical studies to summarize current knowledge on the role of gut microbiota metabolites in the regulation of mammalian bioenergetics and discuss their potential involvement in the development of cardiometabolic disorders. Overall, the available data demonstrates that gut bacteria products affect physiological and pathological processes controlling energy and vascular homeostasis. Thus, the modulation of microbiota-derived metabolites may represent a new approach for treating obesity, hypertension and type 2 diabetes.

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Effects of gut microbiota on atherosclerosis through hydrogen sulfide

Cited by 23 publications

References 108 publications

Emerging roles of cystathionine β-synthase in various forms of cancer

Emerging roles of cystathionine β-synthase in various forms of cancer

Contribution of Hydrogen Sulfide to Physiological and Pathological Events and Clinical Use

The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health

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