Effects of Guanabenz Therapy on Renal Function and Body Fluid Composition

Bauer, John H.

doi:10.1001/archinte.1983.00350060087014

Cited by 14 publications

(2 citation statements)

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“…It has been argued that these receptive sites could inhibit sodium reabsorption, since they have been localized to the proximal tubular basolateral membranes in rabbits (Coupry et al, 1989) and a number of drugs with high affinity for I2binding sites inhibit Na+/H+ exchange by a non-adrenoceptor mechanism (Frelin et al, 1986;Bidet et al, 1990). There is also some evidence from studies in anaesthetized dogs suggesting that guanabenz is natriuretic (Strandhoy et al, 1982;1983).…”

Section: Effects Of Guanabenz and Rilmenidinementioning

confidence: 99%

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Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors

Evans

Anderson

1995

British J Pharmacology

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1 We tested the renal effects of the a2-adrenoceptor agonists, rilmenidine and guanabenz and the antagonists, 2-methoxyidazoxan and idazoxan, in conscious dogs. Our aim was to test the hypothesis that putative imidazoline (I) receptors influence renal function. We reasoned that since rilmenidine and guanabenz are selective for Ih-and I2-binding sites respectively, an influence of one of these receptive sites on renal function would be reflected in qualitative differences between the effects of these agents. Moreover, effects mediated by putative I-receptors should be relatively resistant to antagonism by the selective c2-adrenoceptor antagonist, 2-methoxyidazoxan. Since the effects of these drugs on renal function could be mediated in the central nervous system or periphery, the dogs were studied under both normal and ganglion-blocked conditions. 2 In dogs with intact autonomic reflexes, 2-methoxyidazoxan (15 jg kg-' plus 0.6 jig kg-' min-') produced effects consistent with a generalized increase in sympathetic drive, including increases in mean arterial pressure and plasma renin activity, and a reduction in sodium excretion. In ganglion-blocked dogs, 2-methoxyidazoxan reduced sodium excretion but had no discernible effect on systemic or renal haemodynamics. We conclude that an o2-adrenoceptor-mediated mechanism in the central nervous system tonically inhibits sympathetic drive in the conscious dog. 3 In ganglion-blocked dogs idazoxan (3-300 gg kg-') dose-dependently increased arterial pressure. This was not abolished by concomitant administration of 2-methoxyidazoxan (0.3-30 gg kg-'). The pressor effect of idazoxan is therefore probably mediated by an agonist action at ax-adrenoceptors. 4 The effects of infusions of rilmenidine (0.1-1.0 mg kg-') and guanabenz (10-100 jg kg-') were indistinguishable. They comprised dose-dependent increases in mean arterial pressure, urine excretion, and glomerular filtration rate (the latter in ganglion blocked dogs only), and dose-dependent reductions in heart rate, renal blood flow and sodium excretion (only in dogs with intact autonomic reflexes). All of these effects were antagonized by 2-methoxyidazoxan. 5 We conclude that the renal effects of rilmenidine and guanabenz infusions in conscious dogs are predominantly, if not completely, attributable to activation of M2-adrenoceptors. Our results do not support the hypothesis that putative I-receptors contribute towards the renal effects of these agents.

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Section: Effects Of Guanabenz and Rilmenidinementioning

confidence: 99%

“…Moreover, clinical studies of the acute and chronic effects of guanabenz suggest that it lacks the salt retaining effects of more selective a2-adrenoceptor agonists such as a-methyldopa and clonidine (Walker et al, 1981;Bauer, 1983;Gehr et al, 1986).…”

Section: Effects Of Guanabenz and Rilmenidinementioning

confidence: 99%

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors

Evans

Anderson

1995

British J Pharmacology

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Effects of Indoramin Therapy on BP, Renal Function, and Body Fluid Composition

Bauer¹

1984

Arch Intern Med

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Long-term Effects of Antihypertensive Agents on Proteinuria and Renal Function

Maki¹

1995

Arch Intern Med

228

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Long-term beneficial effects of antihypertensive agents on proteinuria and glomerular filtration rate are proportional to blood pressure reductions and are similar in diabetic and nondiabetic patients with renal disease. In addition, angiotensin-converting enzyme inhibitors, and possibly nondihydropyridine calcium antagonists, have additional beneficial effects on proteinuria that are independent of blood pressure reductions.

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Effects of Guanabenz Therapy on Renal Function and Body Fluid Composition

Cited by 14 publications

References 14 publications

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors

Effects of Indoramin Therapy on BP, Renal Function, and Body Fluid Composition

Long-term Effects of Antihypertensive Agents on Proteinuria and Renal Function

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Effects of Guanabenz Therapy on Renal Function and Body Fluid Composition

Cited by 14 publications

References 14 publications

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α2–adrenoceptors

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α2–adrenoceptors

Effects of Indoramin Therapy on BP, Renal Function, and Body Fluid Composition

Long-term Effects of Antihypertensive Agents on Proteinuria and Renal Function

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Product

Resources

About

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors

Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system α₂–adrenoceptors