Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults

Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed

“…IGF-1 also has protective effects on the neurobiological processes that are compromised by aging and Alzheimer's disease (AD), including those with potent neurotrophic and neuroprotective actions (Baker et al, 2012;de la Monte and Wands, 2005;Deak and Sonntag, 2012;Sonntag et al, 2005). A decrease in IGF-1 may be related to the pathology of AD because IGF-1 increases clearance of amyloid beta (Ab) in the brain and upregulates Ab carriers and transport of Ab-carrier protein complexes (Carro et al, 2002(Carro et al, , 2006.…”

“…The common features of MCI, particularly in cases showing progression to AD, are higher levels of Ab42 and tau, brain atrophy, and reduced cognitive function (Petersen, 2011). Subcutaneous injections of growth hormoneereleasing hormone enhances the IGF-1 level and improves cognitive function in MCI subjects (Baker et al, 2012), but it is unclear whether lower levels of serum IGF-1 are a characteristic of MCI.…”

Effect of GenF20 Plus on serum IGF-1 levels in healthy adults: a randomized controlled study

“…An improvement in cognitive functioning in HGH-deficient patients by HGH substitution has also been shown in a few studies. 19,20 The present study was undertaken with a postulated role of GenF20 Plus in stimulating the anterior pituitary gland to secrete HGH, which when released into the blood stream, stimulates the liver to produce IGF-1, the primary mediator of the effects of HGH. GenF20 Plus contains essential amino acids and other ingredients that are known to stimulate the production and secretion of HGH from the anterior pituitary gland.…”

Update and New Directions in Therapeutics for Neurological Complications of HIV Infections

“…Thus, Baker et al administered tesamorelin or placebo subcutaneously in a randomized fashion for 20 weeks to 137 HIV-uninfected older adults. Tesamorelin was statistically significantly superior to placebo both globally and on measures of improvement in executive function in both subgroups [5]. A randomized trial of tesamorelin for HAND is currently underway [18].…”