Effects of growth hormone and thyroxine on kidney insulin-like growth factor-I and renal growth in hypophysectomized rats

Marshall, Sally M.; Flyvbjerg, Allan; Jørgensen, K. D.; Weeke, Jørgen; Ørskov, Hans

doi:10.1677/joe.0.1360399

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Significant decreases in heart weight, gastrocne¬ mius protein and in tissue concentrations of IGF-I and mRNA for IGF-I were noted in the saline-treated hypophysectomized rats over the period of the experi¬ ment; this is consistent with similar changes demon¬ strated in the kidney (Marshall et al 1993). This recovery period of 14 days following hypophysectomy is frequently used but after such an operation the animals are evidently still in a dynamic state for some time and it is important to monitor changes which are occurring from the start of the experiment.…”

Section: Amount Of Igf-i Mrnasupporting

confidence: 78%

Interactions between growth hormone and nutrition in hypophysectomized rats: body composition and production of insulin-like growth factor-I

Bates¹,

Loughna²,

Pell³

et al. 1993

Journal of Endocrinology

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Hypophysectomy of adult rats results in a loss of body growth which can be reversed by treatment with GH. The increased growth caused by administration of GH is accompanied by an increase in food consumption. The effects of GH and interactions with nutrition were investigated by treating hypophysectomized rats with GH and either providing unrestricted food or preventing the increased food consumption by pair-feeding with the same intake as that of the hypophysectomized animals. Over the 7-day experimental period, the GH-treated animals grew significantly when food was available ad libitum but did not gain body weight when an increase in food intake was prevented. However, there was a significant interaction between GH and nutrition on body composition; GH significantly decreased body fat and increased the protein: fat ratio only in the animals with the restricted intake. Gastrocnemius muscle weight was increased by GH regardless of food intake, but heart weight did not increase and liver weight was actually decreased by GH treatment when food intake was restricted. Serum concentrations of insulin and insulin-like growth factor-I (IGF-I) were increased by GH in the rats with food available ad libitum but not in the pair-fed rats. However, the liver concentration of IGF-I and its mRNA were increased by GH although the increase in IGF-I mRNA was modulated by the restricted food intake. The decreased weight of the liver in the pair-fed GH-treated rats, despite the increase in IGF-I mRNA, suggests that IGF-I does not influence liver growth. In the gastrocnemius muscle, however, GH increased IGF-I mRNA concentration similarly in both rats with food available ad libitum and in pair-fed rats. Decreased nutrition therefore modulated the action of GH but emphasized its nutrient partitioning effect, thus increasing the anabolic drive towards skeletal muscle growth; this appeared to be mediated by the local production of IGF-I within the muscle.

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Section: Amount Of Igf-i Mrnasupporting

confidence: 78%

Interactions between growth hormone and nutrition in hypophysectomized rats: body composition and production of insulin-like growth factor-I

Bates¹,

Loughna²,

Pell³

et al. 1993

Journal of Endocrinology

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“…It thus seems clear that although renal IGF-I mRNA accumulation takes place both in hypophysectomized untreated and p-UC-UBI-hGH and pEGFP-N1-treated mice, the regulation may be essentially different, theoretically involving enhanced non-transcriptional and/or post-transcriptional mechanisms. Previously it was shown that treatment with physiological doses of thyroxin (T4) stimulated and increased renal weight, and it was suggested that renal growth is not primarily mediated through IGF-I, but by an alternative mechanism [13]. It has previously been demonstrated that treatment of hypophysectomized animals with similar doses of T4 normalizes the renal content of T3 and the activity of the iodothyronine deiodase, whereas hGH treatment has little effect on these parameters [8].…”

Section: Discussionmentioning

confidence: 99%

Differential effects on kidney and liver growth of a non-viral hGH-expression vector in hypophysectomized mice

Khamaisi

Søndergaard

Segev

et al. 2007

Growth Hormone & IGF Research

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Immunolike growth hormone substance in tissues from human embryos/fetuses and adults

Costa

Zoppetti

Benedetto

et al. 1993

J Endocrinol Invest

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GH immunolike reactivity was measured by RIA and IRMA tests in the extracts of tissues from human fetuses (8-32 weeks) and adults. For some fetal tissues a comparison was made with the T4 values obtained in a previous study. Both hormones were already measurable in peripheral tissues at 8 weeks of gestation. The increase in GH was faster than for T4 and it reached the zenith at approximately 20 weeks; thereafter, the GH concentration declined until delivery. In contrast, T4 progressively increased until term. Thirteen tissues were studied both in fetuses and in adults: the GH concentration was about 10 times higher in fetal tissues, with the exception of the brain and the pancreas. The brain showed the lowest GH concentration throughout fetal life and adulthood, whereas the highest GH levels were recorded in adults' pancreas, but they resulted to be artifacts since the RIA values were not confirmed by the IRMA test. In both groups of subjects the highest GH concentrations were found in kidneys, liver and small intestine; the lowest, beyond the brain, in red muscle and cartilage. Thus, the pattern of the quantitative distribution of GH in fetal tissues is the same as in adults, suggesting a functional role of the hormone in the developing human during the prenatal period, in contrast with the concept that high tissue levels of GH are a mere reflection of high GH blood levels. Moreover, in all tissues examined no correlation was found between GH and T4 concentration.

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Effects of growth hormone and thyroxine on kidney insulin-like growth factor-I and renal growth in hypophysectomized rats

Cited by 8 publications

References 16 publications

Interactions between growth hormone and nutrition in hypophysectomized rats: body composition and production of insulin-like growth factor-I

Interactions between growth hormone and nutrition in hypophysectomized rats: body composition and production of insulin-like growth factor-I

Differential effects on kidney and liver growth of a non-viral hGH-expression vector in hypophysectomized mice

Immunolike growth hormone substance in tissues from human embryos/fetuses and adults

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