Effects of green tea on lipid metabolism in overweight or obese people: A meta‐analysis of randomized controlled trials

Yuan, Fen; Dong, Hua; Fang, Ke; Gong, Jing; Lu, Fu-Er

doi:10.1002/mnfr.201601122

Cited by 26 publications

(22 citation statements)

References 63 publications

(91 reference statements)

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“…Next, evidence was strongest in relation to cholesterol and lipid levels. Green tea appears to be more strongly related to reduced total and LDL cholesterol, as evidenced by a large number of metaanalytical publications [22,23,[36][37][38]. For black tea those with a higher cardiovascular risk appear to have more benefit [11] with indications from RCTs suggesting that black tea could reduce triglyceride levels, alter body fat distribution and increase fat excretion [6,40,44].…”

Section: Discussionmentioning

confidence: 99%

“…Eight meta-analysis articles studied the effects of tea consumption on cholesterol and lipid levels [8,22,23,[34][35][36][37][38]. A large body of these suggest that green tea and its associated catechins could contribute to reductions in total and low-density lipoprotein (LDL) cholesterol [22,23,[36][37][38]. Another investigation where black and green tea were analysed together showed favourable effects on LDL cholesterol [8] though the inclusion of green tea could have driven this.…”

Section: Cholesterol and Lipidsmentioning

confidence: 99%

“…Yuan et al [36]; Khalesi S et al [6]; Onakpoya I et al [7]; Kim et al [37]; Zheng et al [38] Green and black tea types when analysed together (Cochrane review) show favourable effects on LDL cholesterol.…”

Section: Health Outcome Strength and Amount Of Evidence From Human Stmentioning

confidence: 99%

“…Yuan et al [36]; Khalesi et al [6]; Onakpoya I et al [7]; Kim et al [37]; Zheng et al [38] Zhao et al [34] Longer-term trials imply that black tea may reduce triglyceride levels, alter body fat distribution and increase fat excretion.…”

Section: Strength and Amount Of Evidence Referencesmentioning

confidence: 99%

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Effects Of Tea Consumption On Measures Of Cardiovascular Disease: A Systematic Review Of Meta-Analysis Studies And Randomised Controlled Trials

Etheridge¹,

Bond²,

Derbyshire³

2018

J Nutr Food Sci

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Background: The results of meta-analysis studies and randomised controlled trials (RCTs) published in the last 10 years were collated and the effect of tea consumption on measures of cardiovascular disease (CVD) was considered. Methods: PubMed was systematically searched for relevant meta-analysis papers and RCTs. Inclusion and exclusion of studies, data extraction, and quality assessment were conducted according to the PRISMA statement. The Jadad criteria was applied to decipher the quality of RCTs. Results: Findings from 19 meta-analysis and 23 randomised controlled trials (n=1,422 participants) were evaluated. Clear evidence was found for blood pressure where 4 to 5 cups of black or green tea daily related to risk reduction. Moderate evidence was of a positive effect of green tea and its associated catechins on total and lowdensity lipoprotein (LDL) reduction. Growing evidence indicates that tea drinking could protect vascular health and reduce inflammation. A wider range of tea forms (chamomile tea, goishi tea, hibiscus tea, sour tea, rooibos tea) are increasingly being studied and also appear to have potentially favourable effects on markers of CVD. Conclusion: Tea drinking appears to play a significant role in blood pressure reduction, particularly amongst those with prehypertension or hypertension. Green tea has beneficial effects on total and LDL cholesterol reduction. Tea drinking in general appears to aid vascular function and the reduction of inflammation. Ongoing long-term trials are needed especially in relation to other tea forms alongside black and green tea.

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Section: Discussionmentioning

confidence: 99%

Section: Cholesterol and Lipidsmentioning

confidence: 99%

Section: Health Outcome Strength and Amount Of Evidence From Human Stmentioning

confidence: 99%

Section: Strength and Amount Of Evidence Referencesmentioning

confidence: 99%

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Effects Of Tea Consumption On Measures Of Cardiovascular Disease: A Systematic Review Of Meta-Analysis Studies And Randomised Controlled Trials

Etheridge¹,

Bond²,

Derbyshire³

2018

J Nutr Food Sci

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“…GTE have been shown to exhibit promising results against different types of carcinomas (Larsen, Dashwood, & Bisson, 2010;Namita, Mukesh, & Vijay, 2012;Nanjappan et al, 2019;Schonthal, 2011;Shih, Lin, Lin, Liu, & Kao, 2016;Shirakami, Shimizu, & Moriwaki, 2012). The beneficial effect of green tea or GTPs for weight loss or anti-obesity is also popular globally (Yuan, Dong, Fang, Gong, & Lu, 2018). Palbociclib (PAL) is a selective inhibitor of cyclin-dependent kinases (CDK-4/6) that targets several oncogenic issues concerned with cancer.…”

Section: Introductionmentioning

confidence: 99%

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC–QTOF–MS method

Paul

Surendran

Chandrakala

et al. 2019

Biomedical Chromatography

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Green tea extracts (GTE) has been reported to be a kinase inhibitor and modulator for various drug metabolizing enzymes. It may give synergetic antioncogenic effect, but with a possibility of pharmacokinetic interactions with various co‐administered anticancer agents like palbociclib (PAL), a selective inhibitor of CDK‐4/6 primarily metabolized by CYP3A enzyme. To explore the impact of GTE on PAL pharmacokinetics in Sprague–Dawley rats, a rapid and sensitive UHPLC–QTOF–MS method was established. Chromatographic separation was carried out on an Acquity UPLC BEH C18 (100 × 2.1 mm, 1.7 μm) column using a gradient mobile phase system consisting of 0.1% formic acid and acetonitrile. Sample preparation was based on a simple protein precipitation method. Estimation of target ions [M + H]+ at m/z 448.2455 for PAL and m/z 441.2044 for ibrutinib (IS) was performed in selective ion mode ESI–HRMS. Good sensitivity (1.0 ng/mL) and linearity over a wide concentration range of 1–2000 ng/mL was exhibited by the method. The results indicated that the administration of GTE resulted in decreased oral bioavailability of PAL in both short‐ and long‐term conditions. However, when both conditions were compared, the variation was less for the peak concentration and area under the concentration–time curve level of PAL.

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Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials

Mahmoodi

Hosseini

Kazemi

et al. 2020

Phytotherapy Research

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The therapeutic potential of green tea as a rich source of antioxidants and anti‐inflammatory compounds has been investigated by several studies. The present study aimed to systematically review and analyze randomized clinical trials (RCTs) assessing the effects of green tea, catechin, and other forms of green tea supplementation on levels of liver enzymes. PubMed, SCOPUS, EMBASE, and Cochrane databases were searched until February 2019. All RCTs investigating the effect of green tea or its catechin on liver enzymes including alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin were included. A total of 15 RCTs were included. The overall effect of green tea on liver enzymes was nonsignificant (ALT [Standardized mean difference (SMD)= −0.17, CI −0.42 to 0.08, p = .19], AST [SMD = −0.07, CI −0.43 to 0.29, p = .69], and ALP [SMD = −0.17, CI −0.45 to 0.1, p = .22]). However, subgroup analyses showed that green tea reduced the levels of liver enzymes in participants with nonalcoholic fatty liver disease (NAFLD) but in healthy subjects, a small significant increase in liver enzymes was observed. In conclusion, the results of this study suggest that the effect of green tea on liver enzymes is dependent on the health status of individuals. While a moderate reducing effect was observed in patients with NAFLD, in healthy subjects, a small increasing effect was found.

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Effects of green tea on lipid metabolism in overweight or obese people: A meta‐analysis of randomized controlled trials

Cited by 26 publications

References 63 publications

Effects Of Tea Consumption On Measures Of Cardiovascular Disease: A Systematic Review Of Meta-Analysis Studies And Randomised Controlled Trials

Effects Of Tea Consumption On Measures Of Cardiovascular Disease: A Systematic Review Of Meta-Analysis Studies And Randomised Controlled Trials

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC–QTOF–MS method

Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta‐analysis of randomized clinical trials

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