Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats

Kaur, Taranpreet; Pathak, Chander Mohan; Pandhi, P; Khanduja, Krishan Lal

doi:10.1016/j.bandc.2007.10.003

Cited by 78 publications

(49 citation statements)

References 35 publications

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“…After 8 weeks of oral administration of 0.5% green tea extract, a decline in AchE activity was observed in the cerebrum of young rats. 20 Feeding mice with tea polyphenol (0.2%) for 7 weeks also resulted in a reduced AchE activity in the brain. 27 This potential pathway of beneficial effects on cognition and the symptoms of Alzheimer's disease may work via induction of cellular neutral endopeptidase activity in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…[19][20][21][22][23] Also, as green tea catechins are known to promote antioxidative activity in the brain it was investigated whether these substances can prevent Ab-induced cognitive impairment. 24,25 Oral treatment with epigallocatechin gallate, the main polyphenolic constituent of green tea, decreased Ab levels and plaques in mice, suggesting an activation of the a-secretase proteolytic pathway preventing the generation of Ab plaques.…”

Section: Discussionmentioning

confidence: 99%

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Neural effects of green tea extract on dorsolateral prefrontal cortex

et al. 2012

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BACKGROUND/OBJECTIVES: Green tea is being recognized as a beverage with potential benefits for human health and cognitive functions. In vivo studies provide preliminary evidence that green tea intake may have a positive role in improving effects on cognitive functions. We aimed to examine the neural effects of green tea extract on brain activation in humans. SUBJECTS/METHODS: Functional magnetic resonance imaging was recorded while 12 healthy volunteers performed a working memory task following administration of 250 or 500 ml of a milk whey based green tea containing soft drink or milk whey based soft drink without green tea as control in a double-blind, controlled repeated measures within-subject design with counterbalanced order of substance administration. A whole-brain analysis with a cluster-level threshold of Po0.001 (unadjusted) was followed by an a priori-defined region of interest (ROI) analysis of the dorsolateral prefrontal cortex (DLPFC) including a cluster-level threshold of Po0.05 and family-wise error (FWE) adjustment for multiple comparisons. RESULTS: Whole-brain analyses revealed no significant effects after correction for multiple comparisons (FWE Po0.05). Using a ROI approach, green tea extract increased activation in the DLPFC relative to a control condition (FWE Po0.001). This neural effect was related to green tea dosage. Green tea extract was not associated with any significant attenuation in regional activation relative to control condition. CONCLUSIONS: These data suggest that green tea extract may modulate brain activity in the DLPFC, a key area that mediates working memory processing in the human brain. Moreover, this is the first neuroimaging study implicating that functional neuroimaging methods provide a means of examining how green tea extract acts on the brain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neural effects of green tea extract on dorsolateral prefrontal cortex

et al. 2012

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“…Polyphenols, particularly flavonoids, have been shown to ameliorate learning and memory processes and are today extensively studied for their potential to prevent age-related cognitive decline in both animals [7][8][9][10][11] and humans [12][13][14][15][16][17]. Although the mechanisms of action of flavonoids remain unclear, there is evidence that they modulate cellular and molecular processes involved in learning and memory [18].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of berry polyphenols against age-related cognitive impairment

Bensalem

Dal-Pan

Gillard

et al. 2016

NUA

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Abstract.A growing body of evidence suggests that dietary interventions may delay or halt the progression of age-related health disorders and cognitive decline. Among the components of the human diet, polyphenols from berries are essential micronutrients that have been particularly studied for improving cognitive functions. In the present review, we highlight the health impact of major polyphenolic classes found in berries: flavanols, anthocyanins and stilbenes, focusing on resveratrol. The reports of beneficial effects of berry consumption on age-related cognitive decline and associated neurobiological processes in animals and human are underscored. We then discuss the potential benefit of each category of polyphenols on memory impairment and in neurodegenerative diseases. Berry polyphenols improve several types of memory and have a global effect on brain plasticity, partly through their antioxidant activity and/or their effect on neuronal signal transduction and neuroinflammation. Interestingly, accumulated bioavailability data suggest that most polyphenols, or at least key metabolites, can access the brain in sufficient concentrations. Collectively, the data accumulated so far suggest that dietary polyphenols can modulate brain health and function, and strengthen the importance of fruit consumption for a healthy brain aging and the prevention of age-related diseases. However, further preclinical work is needed to determine the most neuroactive nutraceutical formulations, whether through the diet or supplement, to subsequently design and perform informative clinical trials.

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“…In particular, studies using Camellia sinensis (tea) [7][8][9][10][11][12], Gingko Biloba [13][14][15], Theobroma cacao (cocoa) [16][17][18] and Vaccinium spp (blueberry) [19][20][21][22][23] have demonstrated beneficial effects on memory and learning in both humans and animal models. Whilst these studies clearly demonstrate the efficacy of flavonoid-rich foods in promoting cognitive performance, they fall short of providing evidence that flavonoids themselves are the causal agents in driving beneficial effects on memory, learning and neuro-cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

Association Between Psychiatric Disorders and Iron Defi ciency Anemia Among Children And Adolescents: A Nationwide Population-Based Study

Croft¹

2015

Prenatal and Childhood Nutrition

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Evidence suggests that flavonoid-rich foods are capable of inducing improvements in memory and cognition in animals and humans. However, there is a lack of clarity concerning whether flavonoids are the causal agents in inducing such behavioral responses. Here we show that supplementation with pure anthocyanins or pure flavanols for 6 weeks, at levels similar to that found in blueberry (2% w/w), results in an enhancement of spatial memory in 18 month old rats. Pure flavanols and pure anthocyanins were observed to induce significant improvements in spatial working memory (p = 0.002 and p = 0.006 respectively), to a similar extent to that following blueberry supplementation (p = 0.002). These behavioral changes were paralleled by increases in hippocampal brain-derived neurotrophic factor (R = 0.46, p,0.01), suggesting a common mechanism for the enhancement of memory. However, unlike protein levels of BDNF, the regional enhancement of BDNF mRNA expression in the hippocampus appeared to be predominantly enhanced by anthocyanins. Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods.

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Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats

Cited by 78 publications

References 35 publications

Neural effects of green tea extract on dorsolateral prefrontal cortex

Neural effects of green tea extract on dorsolateral prefrontal cortex

Protective effects of berry polyphenols against age-related cognitive impairment

Association Between Psychiatric Disorders and Iron Defi ciency Anemia Among Children And Adolescents: A Nationwide Population-Based Study

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