Effects of graphene oxide and graphene oxide quantum dots on the osteogenic differentiation of stem cells from human exfoliated deciduous teeth

Yang, Xin; Zhao, Qi; Chen, Yijing; Fu, Yuan-Xiang; Lu, Shu-Shen; Yu, Xinlin; Yu, Dongsheng; Zhao, Wei

doi:10.1080/21691401.2019.1576706

Cited by 22 publications

(24 citation statements)

References 54 publications

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“…Thus, systematic studies that focus on the relationships of various parameters (i.e., the surface functionalities, sizes, surface charges, shapes, dimensions, mechanical strength, etc.) and their effects on promoting cell proliferation and osteogenic differentiation would be highly desired; and this type of study would provide invaluable insights for the rational design of innovative carbon‐based nanomaterial BTE scaffolds …”

Section: Resultsmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

130

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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Section: Resultsmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

130

106

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“…Stem cells from different sources could be used as progenitor cells in the process of bone formation, so their recruitment and osteogenic differentiation were key factors for effective bone regeneration. GDs were proved to have the ability of osteogenic induction, [144][145][146][147][148][149][150][151][152] as shown in Table 4. In this subsection, the signaling pathways involved in GDs-induced bone regeneration were discussed, including which signaling pathways of osteogenic differentiation of stem cells from different sources were affected by GDs and the effect of GDsrelated parameters on the signaling pathway.…”

Section: Mechanism Of Gds-induced Bone Regeneration Possible Signalinmentioning

confidence: 99%

<p>Applications of Graphene and Its Derivatives in Bone Repair: Advantages for Promoting Bone Formation and Providing Real-Time Detection, Challenges and Future Prospects</p>

Du¹,

Wang

Zhang³

et al. 2020

IJN

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During continuous innovation in the preparation, characterization and application of various bone repair materials for several decades, nanomaterials have exhibited many unique advantages. As a kind of representative two-dimensional nanomaterials, graphene and its derivatives (GDs) such as graphene oxide and reduced graphene oxide have shown promising potential for the application in bone repair based on their excellent mechanical properties, electrical conductivity, large specific surface area (SSA) and atomic structure stability. Herein, we reviewed the updated application of them in bone repair in order to present, as comprehensively, as possible, their specific advantages, challenges and current solutions. Firstly, how their advantages have been utilized in bone repair materials with improved bone formation ability was discussed. Especially, the effects of further functionalization or modification were emphasized. Then, the signaling pathways involved in GDs-induced osteogenic differentiation of stem cells and immunomodulatory mechanism of GDs-induced bone regeneration were discussed. On the other hand, their applications as contrast agents in the field of bone repair were summarized. In addition, we also reviewed the progress and related principles of the effects of GDs parameters on cytotoxicity and residues. At last, the future research was prospected.

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“…They demonstrated that GQDs enhanced alkaline phosphatase activity and expression of several osteogenic markers in the stem cells. In a recent study, Yang et al 56 studied and compared the effect of GO and GQDs on the osteogenic differentiation of human stem cells sourced from exfoliated deciduous teeth (SHEDs). The uptake of GQDs by the SHEDs and their cytoplasmic distribution were confirmed using the fluorescent property of GQDs.…”

Section: Interaction With Stem Cellsmentioning

confidence: 99%

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

Ghosh¹,

Chatterjee²

2020

IJN

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Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implantassociated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.

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Effects of graphene oxide and graphene oxide quantum dots on the osteogenic differentiation of stem cells from human exfoliated deciduous teeth

Cited by 22 publications

References 54 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

<p>Applications of Graphene and Its Derivatives in Bone Repair: Advantages for Promoting Bone Formation and Providing Real-Time Detection, Challenges and Future Prospects</p>

<p>Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances</p>

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