Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats

Cui, Xiaopei; Li, Baoying; Gao, Haiqing; Wei, Na; Wang, Weiling; Lü, Mei

doi:10.3177/jnsv.54.321

Cited by 77 publications

(66 citation statements)

References 32 publications

(25 reference statements)

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“…Uchida et al reported that GSPE had a significant antinociceptive effect in mice during the formalin test (Uchida et al, 2008), and Cui et al showed that GSPE plays a protective role against diabetic peripheral neuropathy by ameliorating nerve damage associated with oxidation (Cui et al, 2008). These results suggest that GSPE has an antinociceptive effect.…”

Section: Discussionsupporting

confidence: 55%

Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

et al. 2011

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Abbreviations: GSPE, grape seed proanthocyanidin extract; MIA, monosodium iodoacetate; MMP, matrix metalloproteinase; O2 -, superoxide anion; OA, osteoarthritis; OH, hydroxyl radicals; ONOO -, peroxynitrite; PWL, paw withdrawal latency; PWT, paw withdrawal threshold; ROS, reactive oxygen species; TRP, transient receptor potential; VIP, vasoactive intestinal peptide Abstract Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the progression of OA. We investigated the effects of grape seed proanthocyanidin extract (GSPE), which is an antioxidant, on monosodium iodoacetate (MIA)-induced arthritis of the knee joint of rat, which is an animal model of human OA. GSPE (100 mg/kg or 300 mg/kg) or saline was given orally three times per week for 4 weeks after the MIA injection. Pain was measured using the paw withdrawal latency (PWL), the paw withdrawal threshold (PWT) and the hind limb weight bearing ability. Joint damage was assessed using histological and microscopic analysis and microcomputerized tomography. Matrix metalloproteinase-13 (MMP13) and nitrotyrosine were detected using immunohistochemistry. Administration of GSPE to the MIA-treated rats significantly increased the PWL and PWT and this resulted in recovery of hind paw weight distribution (P ＜ 0.05). GSPE reduced the loss of chondrocytes and proteoglycan, the production of MMP13, nitrotyrosine and IL-1β and the formation of osteophytes, and it reduced the number of subchondral bone fractures in the MIA-treated rats. These results indicate that GSPE is antinociceptive and it is protective against joint damage in the MIA-treated rat model of OA. GSPE could open up novel avenues for the treatment of OA.

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Section: Discussionsupporting

confidence: 55%

Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

et al. 2011

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“…The superoxide anion scavenging activity of GSPE was stronger than vitamin C, vitamin E or any other antioxidant. 1) It has been reported to have protective effects on various cardiac disorders, correct dyslipidemia associated with high-fat diet, 2) decrease arterial pressure in estrogen-depleted female spontaneously hypertensive rats, 3) prevent diabetic nephropathy and neuropathy from progressing, 4,5) and most importantly, ameliorate atherosclerosis, 6) possibly attributed to its endothelial protective potential.…”

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confidence: 99%

Grape Seed Proanthocyanidin Extracts Enhance Endothelial Nitric Oxide Synthase Expression through 5′-AMP Activated Protein Kinase/Surtuin 1–Krüpple Like Factor 2 Pathway and Modulate Blood Pressure in Ouabain Induced Hypertensive Rats

Cui

Liu

Feng

et al. 2012

Biological & Pharmaceutical Bulletin

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Grape seed proanthocyanidin extracts (GSPE) belonging to polyphenols, possess various biological effects including anti-inflammation, anti-oxidant, anti-aging, anti-atherosclerosis, etc. GSPE is potential in regulating endothelial function. However, the underlying mechanism is not clear yet. In this study, by small interfering RNA (siRNA) knocking down, we proved that GSPE increase endothelial nitric oxide synthase (eNOS) expression in human umbilical vessel cells (HUVECs) in vitro, which was attributed to its transcription factor Krüpple like factor 2 (KLF2) induction. Furthermore, GSPE activate 5′-AMP activated protein kinase (AMPK) and increase surtuin 1 (SIRT1) protein level, critical for KLF2 induction. We also illuminated the role of GSPE in hypertension treatment. By chronic administration of GSPE in ouabain induced hypertensive rats model, we access the effect of GSPE on blood pressure regulation and the possible mechanisms involved. After 5 weeks feeding, GSPE significantly block the ouabain induced blood pressure increase. The aortic NO production impaired by ouabain was improved. In conclusion, GSPE increase eNOS expression and NO production in an AMPK/SIRT1 dependent manner through KLF2 induction, and attenuate ouabain induced hypertension.Key words grape seed proanthocyanidin; endothelial nitric oxide synthase; hypertension; Krüpple like factor 2 Grape seed proanthocyanidin extracts (GSPE), belonging to polyphenols, is a potent antioxidant extracted from grape seeds and skins. The superoxide anion scavenging activity of GSPE was stronger than vitamin C, vitamin E or any other antioxidant.

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“…These results suggest that these animals suffered growth retardation due to the hindrance of glucose uptake (26) but oral GSE supplementation did not affect body weight in diabetic rats. Although in recent studies (14,26,27) it has been suggested that oral GSE supplementation increased body weight changes in diabetic rats compared to the untreated diabetic controls, in these studies the GSE dosage was larger (250 mg kg -1 day -1…”

Section: Discussionmentioning

confidence: 67%

Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin-induced diabetic rats

Belviranlı¹,

Gökbel²,

Okudan³

et al. 2015

Turk J Med Sci

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Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats.Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg -1 day -1 ) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed.Results: Both XO and ADA activities increased and NO levels decreased in diabetic rats (P < 0.05). GSE supplementation normalized all of these changes. Antioxidant enzyme activities decreased in diabetic rats compared to the controls (P < 0.05). GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05). Conclusion:These findings suggest that 6 weeks of oral GSE supplementation may prevent oxidative stress and improve antioxidant status in diabetic rats.

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Effects of Grape Seed Proanthocyanidin Extracts on Peripheral Nerves in Streptozocin-Induced Diabetic Rats

Cited by 77 publications

References 32 publications

Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

Grape Seed Proanthocyanidin Extracts Enhance Endothelial Nitric Oxide Synthase Expression through 5′-AMP Activated Protein Kinase/Surtuin 1–Krüpple Like Factor 2 Pathway and Modulate Blood Pressure in Ouabain Induced Hypertensive Rats

Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin-induced diabetic rats

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