Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

Kar, Partha; Laight, David W; Rooprai, Harcharan K.; Shaw, Kenneth; Cummings, Michael H.

doi:10.1111/j.1464-5491.2009.02727.x

Cited by 199 publications

(194 citation statements)

References 33 publications

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“…These results suggest that daily consumption of GPE might prevent hyperglycemia caused by high fat diet. Similar evidence was obtained by Laight et al [29] who reported that consumption of grape seed extract for 4 weeks significantly improved markers of inflammation and glycaemia in obese Type 2 diabetic subjects with 32 patients involved in a double blind randomized placebo controlled trial.…”

Section: Discussionsupporting

confidence: 71%

Grape Pomace Aqueous Extract (GPE) Prevents High Fat Diet-Induced Diabetes and Attenuates Systemic Inflammation

Li¹,

Parry²,

Weeda³

et al. 2016

FNS

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Diabetes mellitus is a group of metabolic syndromes with a hallmark of hyperglycemia. Serious long-term complications from diabetes are a major cause of hospitalization and death. We recently discovered that grape pomace, the by-product from the waste of the wine and juice industries, had great potential to prevent diabetes. In this study, we examined the potential use of grape pomace in controlling high blood glucose in the form of Cabernet Franc Grape pomace aqueous extract (GPE). Both streptozotocin (STZ; 1 × 150 mg/kg)-treated mice and non-STZ treated mice were fed with high fat diet that was supplemented with 2.4 g/kg GPE for 12 weeks. GPE had no significant effect on the blood glucose levels in STZ-treated mice. However, GPE significantly reduced blood glucose levels by 16.1% (p < 0.05) in non-STZ treated mice following a 10-week HFD feeding period when compared with high fat diet controls. GPE reduction of hyperglycemia also promoted a significant reduction of GHbA1c accumulation. Circulating peptide hormones related to glucose homeostasis, including GLP-1, glucagon, DPP-4 and insulin, were drastically altered by GPE. Moreover, GPE attenuated the expressions of insulin, glucagon, and several gut hormones at the mRNA level. In addition, GPE significantly down regulated 5 biomarker genes for systematic inflammation. Taken together, our results highlight a role of GPE as a potential alternative approach to control diabetes epidemic.

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Section: Discussionsupporting

confidence: 71%

Grape Pomace Aqueous Extract (GPE) Prevents High Fat Diet-Induced Diabetes and Attenuates Systemic Inflammation

Li¹,

Parry²,

Weeda³

et al. 2016

FNS

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“…The most frequent observation was an increase of the expression and activity of GPX and SOD and of the levels of GSH [21,22,23]. Only two in vitro studies reported a decrease of GSH [24,25]. In the present study, we were unable to show a significant effect of RES on the antioxidant enzymes.…”

Section: Discussioncontrasting

confidence: 51%

“…Results of clinical studies testing the effect of GSEs on the total antioxidant status are controversial. Two clinical studies that studied the effect of a GSE [17,18] on TAP with the same method as in the present study did not show any significant effect on the antioxidant status. Two other clinical studies that used the total antioxidant capacity [19] or the oxygen radical absorbance capacity [20] methods showed significant increases of antioxidant capacity after GSE (Leucoselect®) or French maritime pine bark extract (Pycnogenol) intake, respectively.…”

Section: Discussionmentioning

confidence: 68%

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Groote¹,

Belleghem²,

Devière³

et al. 2012

Ann Nutr Metab

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Background: The preventive effect of resveratrol (RES) on the development of human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative of RES in which phosphate groups protect the phenolic groups. Aims: This study compared the effect of RTP on biochemical and molecular markers of oxidative stress to equimolar doses (0.66 mmol) of RES and catechin-rich grape seed extract (CGSE) in a model of oxidative and metabolic stress associated with obesity in humans. Methods: Thirty-two obese subjects (BMI between 30 and 40) were enrolled. They all received 1 capsule of placebo/day for 28 days before being randomly devised into three arms receiving 1 capsule/day of RES, CGSE, or RTP during the following consecutive 28 days. Blood samples were collected at baseline, after the end of placebo intake, and after the end of the investigational product intake. Biochemical parameters of oxidative stress and blood expression of 200 redox-related genes were determined at each time point. Results: RTP and CGSE showed better antioxidant activities compared to RES and induced important modulations of gene expression. Conclusion: The results suggest that RTP and CGSE could contribute to a significant reduction of oxidative stress in obese subjects.

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“…Resveratrol, quercetin, catechins, and anthocyanins have been shown to inhibit hyperglycemia, improve beta-cell function, and protect against beta-cell loss. In obese Type 2 diabetic subjects, GSE significantly improved inflammation and glycemic status and decreased oxidative stress and total cholesterol levels (Kar et al 2009). Analyses of epidemiological studies concluded that moderate regular alcohol consumption is associated with an ~30% reduced risk of type 2 diabetes (Howard et al 2004, Koppes et al 2005, indicating that the benefits afforded by the alcohol and polyphenol contents of red wine are probably additive.…”

Section: Type 2 Diabetesmentioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

165

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Abstract:As indicated by epidemiological studies, regular and moderate wine consumption, particularly red wine, has been associated with health benefits. Clinical studies and work performed with animal models indicate that wine may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders, and metabolic syndrome. The mechanism of action has been attributed to antioxidant, lipid regulating, and anti-inflammatory effects. A variety of wine constituents have been studied in various disease models. Both the alcoholic and polyphenolic components of wine are believed to contribute to these beneficial effects. As wine is a complex mixture, it is likely that a multitude of chemical constituents, as well as their metabolites, work synergistically to impact human health. In sum, although wine drinking may be contraindicated in certain individuals, in healthy people, regular consumption of moderate amounts of wine may protect against certain chronic health conditions.

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Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

Abstract: GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk.

Cited by 199 publications

References 33 publications

Grape Pomace Aqueous Extract (GPE) Prevents High Fat Diet-Induced Diabetes and Attenuates Systemic Inflammation

Grape Pomace Aqueous Extract (GPE) Prevents High Fat Diet-Induced Diabetes and Attenuates Systemic Inflammation

Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

Wine and Health: A Review

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