Effects of gonadotropin-releasing hormone administration on the pituitary-gonadal axis in male and female dogs before and after gonadectomy

Gier, J. De; Buijtels, J.J.C.W.M.; Albers-Wolthers, C.H.J.; Oei, Christine; Kooistra, Hans S.; Okkens, A.C.

doi:10.1016/j.theriogenology.2011.10.003

Cited by 30 publications

(47 citation statements)

References 52 publications

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“…We observed maximum oestradiol concentrations at 60-90 min after canine KP-10 administration, which are similar to reported responses to GnRH in anoestrous bitches [32,35,43,44] . This is not surprising, as kisspeptin indirectly stimulates gonadal steroids via hypothalamic GnRH release [1,2,4] .…”

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolsupporting

confidence: 88%

“…FSH concentration also rose rapidly after canine KP-10 administration. The 3-fold increase over basal FSH was similar to that after intravenous GnRH administration in anoestrous bitches [43,44] . Plasma FSH concentrations remained above basal levels for a longer period than plasma LH concentrations.…”

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolsupporting

confidence: 64%

“…Furthermore, the fold changes in LH after the administration of GnRH differ considerably in dogs. The rise in plasma LH concentration compared to basal values after intravenous administration of the GnRH analogue gonadorelin to anoestrous bitches has been reported to be between 16-and 91-fold [43,44] .…”

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolmentioning

confidence: 99%

“…However, in comparison with GnRH antagonists, kisspeptin antagonists only partially inhibit LH, suggesting that GnRH secretion is only partially dependent on kisspeptin input [45] . It is, therefore, not surprising that GnRH induces even higher plasma LH concentrations in the bitch than does canine KP-10 [33,35,43,44] . Similar results were observed by Hashizume et al [16] in GnRH and KP-10 stimulation tests in female goats.…”

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolmentioning

confidence: 99%

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Identification of a Novel Kisspeptin with High Gonadotrophin Stimulatory Activity in the Dog

Albers-Wolthers¹,

Gier²,

Kooistra³

et al. 2014

Neuroendocrinology

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Kisspeptin (KISS1) and its receptor (KISS1r) are essential for normal reproductive function in many species, but the role of kiss1/kiss1r signalling in the dog has not yet been elucidated. The aims of this study were to identify the canine kiss1 and kiss1r genes and to determine gonadotrophin and oestradiol stimulatory activity of KP-10, the shortest biologically active form of KISS1. Canine kiss1 and kiss1r genes were localized by comparing the reference dog genome with relevant human cDNA sequences, using BLASTn software. The amino acid sequence of canine KP-10 (YNWNVFGLRY) differs at two positions from human KP-10 (YNWNSFGLRF). A single bolus of canine KP-10 was administered intravenously to anoestrous Beagle bitches in dosages of 0, 0.1, 0.2, 0.3, 0.5, 1, 5, 10, and 30 μg/kg. Blood samples were collected before and after canine KP-10 administration for the measurement of plasma luteinizing hormone (LH, all doses), follicle-stimulating hormone (FSH) and oestradiol (1-30 μg/kg). From 0.2 μg/kg onwards, canine KP-10 resulted in a rapid and robust rise in plasma LH concentration (max. at 10 min). KP-10 also resulted in a rapid and robust rise in plasma FSH concentration (max. at 10-20 min). Plasma oestradiol concentration increased significantly after dosages of 1, 5, and 10 μg/kg and reached a maximum at 60-90 min. In conclusion, canine KP-10 is a potent kisspeptin which elicits robust gonadotrophin and oestradiol responses in anoestrous bitches, suggesting that canine kiss1/kiss1r are cogent targets for modulating reproduction in dogs.

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Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolsupporting

confidence: 88%

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolsupporting

confidence: 64%

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolmentioning

confidence: 99%

Section: Canine Kp-10 Stimulation Of Lh Fsh and Oestradiolmentioning

confidence: 99%

See 2 more Smart Citations

Identification of a Novel Kisspeptin with High Gonadotrophin Stimulatory Activity in the Dog

Albers-Wolthers¹,

Gier²,

Kooistra³

et al. 2014

Neuroendocrinology

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“…All except 1 of the 11 female dogs were spayed, therefore it could also be hypothesized that cTSH is affected by ovariectomy as has been shown for FSH and LH: Both of these pituitary hormones have been shown to increase after gonadectomy in female and male dogs. 20,21 However, as cTSH concentrations remained unaffected in male dogs after gonadectomy, 22 this hypothesis seems less likely. As case numbers were low, the dominance of female animals could merely be a statistical phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Altered Serum Thyrotropin Concentrations in Dogs with Primary Hypoadrenocorticism before and during Treatment

Reusch

Fracassi

Sieber-Ruckstuhl

et al. 2017

Veterinary Internal Medicne

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BackgroundThyrotropin (TSH) can be increased in humans with primary hypoadrenocorticism (HA) before glucocorticoid treatment. Increase in TSH is a typical finding of primary hypothyroidism and both diseases can occur concurrently (Schmidt's syndrome); therefore, care must be taken in assessing thyroid function in untreated human patients with HA.ObjectiveEvaluate whether alterations in cTSH can be observed in dogs with HA in absence of primary hypothyroidism.AnimalsThirty dogs with newly diagnosed HA, and 30 dogs in which HA was suspected but excluded based on a normal ACTH stimulation test (controls) were prospectively enrolled.MethodscTSH and T4 concentrations were determined in all dogs and at selected time points during treatment (prednisolone, fludrocortisone, or DOCP) in dogs with HA.ResultscTSH concentrations ranged from 0.01 to 2.6 ng/mL (median 0.29) and were increased in 11/30 dogs with HA; values in controls were all within the reference interval (range: 0.01–0.2 ng/dL; median 0.06). There was no difference in T4 between dogs with increased cTSH (T4 range 1.0‐2.1; median 1.3 μg/dL) compared to those with normal cTSH (T4 range 0.5‐3.4, median 1.4 μg/dL; P=0.69) and controls (T4 range 0.3‐3.8, median 1.8 μg/dL; P=0.35). After starting treatment, cTSH normalized after 2–4 weeks in 9 dogs and after 3 and 4 months in 2 without thyroxine supplementation.Conclusions and Clinical RelevanceEvaluation of thyroid function in untreated dogs with HA can lead to misdiagnosis of hypothyroidism; treatment with glucocorticoids for up to 4 months can be necessary to normalize cTSH.

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Endometrial polyp in a spayed female dog

Lai,

Jenkins,

Sumner

et al. 2023

Vet Record Case Reports

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Endometrial polyps are rare benign uterine masses exclusively reported in geriatric, entire, female dogs or spayed female dogs with ovarian remnant syndrome. A 12‐year‐old, female, ovariohysterectomised cocker spaniel was presented for hyporexia, progressive muco‐haemorrhagic vulval discharge, and an ultrasonographically detected caudal abdominal mass. Thoracic and abdominal computed tomography revealed that the mass originated from the uterine stump, with no evidence of metastasis. Surgical excision of the mass was performed, and histopathology of the mass was consistent with an endometrial polyp. The dog was confirmed to be neutered based on the absence of ovarian remnant found on computed tomography and during surgery, and the negative results of both anti‐Mullerian hormone test and human chorionic gonadotropin stimulated progesterone test. The dog fully recovered with complete resolution of clinical signs at 2‐week, 6‐month and 18‐month rechecks. The presenting case highlights the first reported case of an endometrial polyp in a spayed female dog.

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Effects of gonadotropin-releasing hormone administration on the pituitary-gonadal axis in male and female dogs before and after gonadectomy

Cited by 30 publications

References 52 publications

Identification of a Novel Kisspeptin with High Gonadotrophin Stimulatory Activity in the Dog

Identification of a Novel Kisspeptin with High Gonadotrophin Stimulatory Activity in the Dog

Altered Serum Thyrotropin Concentrations in Dogs with Primary Hypoadrenocorticism before and during Treatment

Endometrial polyp in a spayed female dog

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