“…Increases in plasma protein concentration secondary to pregnancy or exogenous estrogens (Doe, Mel/inger, Swaim andSeal 1967, Musa, Doe and have been previously reported, whereas the response of plasma proteins and plasma hormone concentrations to exogenous androgens has been studied less intensively. But the opinion that changes in plasma proteins tend to be opposite to those of estrogen effects has prevailed (Seal and Doe 1969). Tbis is in contrast to the fact that androgens markedly increase the total protein content of the liver and other viscera, along with the anabolie effect on muscle (Munro 1964, KTÜskemper 1968.…”
After administration of 250 mg testosterone oenanthate to six hypogonadal men the following changes in plasma hormone and hormone binding protein concentrations were measured: 3-4 weeks after application thyroxine binding globulin (-31.6%), sexual hormone binding globulin (-19.1%) and cortisol binding globulin (-8%) decreased, whereas the total plasma protein concentration remained unchanged. The corresponding hormone level of cortisol exhibited no concomitant decrease, whereas the fall of thyroxine plasma concentration was almost icentical (-32%) to that of its binding globulin, demonstrating that androgen treatment may lead to incorrect clinical interpretations of hormone concentration data in plasma. The testosterone concentrations reached the normal range of male healthy subjects for 1-2 weeks only. The half concentration time of plasma testosterone after testosterone oenanthate application amounts to 224 ± 18.24 hrs.
“…Increases in plasma protein concentration secondary to pregnancy or exogenous estrogens (Doe, Mel/inger, Swaim andSeal 1967, Musa, Doe and have been previously reported, whereas the response of plasma proteins and plasma hormone concentrations to exogenous androgens has been studied less intensively. But the opinion that changes in plasma proteins tend to be opposite to those of estrogen effects has prevailed (Seal and Doe 1969). Tbis is in contrast to the fact that androgens markedly increase the total protein content of the liver and other viscera, along with the anabolie effect on muscle (Munro 1964, KTÜskemper 1968.…”
After administration of 250 mg testosterone oenanthate to six hypogonadal men the following changes in plasma hormone and hormone binding protein concentrations were measured: 3-4 weeks after application thyroxine binding globulin (-31.6%), sexual hormone binding globulin (-19.1%) and cortisol binding globulin (-8%) decreased, whereas the total plasma protein concentration remained unchanged. The corresponding hormone level of cortisol exhibited no concomitant decrease, whereas the fall of thyroxine plasma concentration was almost icentical (-32%) to that of its binding globulin, demonstrating that androgen treatment may lead to incorrect clinical interpretations of hormone concentration data in plasma. The testosterone concentrations reached the normal range of male healthy subjects for 1-2 weeks only. The half concentration time of plasma testosterone after testosterone oenanthate application amounts to 224 ± 18.24 hrs.
“…Increase in plasma protein by testosterone has been reported in lizards (Rao & David, 1967;Rao, 1968) and mammals (Kochakian, 1964;Seal & Doe, 1969). It is possible that the increase in plasma protein with the high level of testosterone occurs generally in vertebrates.…”
In the water-snake, Natrix piscator, the following are depressed by orchidectomy and restored to normal by testosterone treatment: glucose, free and esterified fatty acids and triglycerides in plasma, hepatic triglycerides, and total esterified fatty acids. The increase in hepatic free fatty acids and muscle glycogen was also reduced to the level found in intact snakes. Moreover, although castration had no effect, testosterone caused a significant increase in liver weight and plasma protein, and a significant decrease in free plasma cholesterol. Except for an increase in triglyceride content by high doses of the hormone, neither castration nor the administration of 5 mg testosterone had any significant effect on the free fatty acid and triglyceride content of the adipose tissue of the snakes.
“…Thirty-eight plasma samples from healthy young women were examined by electrophoresis in 13\m=.\5% starch gel (Smithies, 1955) The existence of a pregnancy protein zone in serum was first described by Smithies (1959) and this was investigated by Cooper (1963) The liver has been shown to be a target organ for the action of oestrogens (Song, Rifkind, Gilette & Kappas, 1969) and altered plasma levels of enzymes synthesized in the liver in response to oestrogen administration have been reported (Seal & Doe, 1969 Henriquet (1962) has suggested that the greater sensitivity to succinyl choline of patients at the end of pregnancy is due to low cholinesterase activity. Unfortunately, no attempt was made to exclude any of the serum cholinesterase variants which are known to be sensitive to this muscle relaxant (e.g.…”
Many changes have been noted in the plasma proteins of women taking oral contraceptives and a similarity between the metabolic effects of oral contraceptive therapy and pregnancy has been observed by Tyler (1964) as well as by Crawford & Rudofsky (1966). The existence of diminished serum cholinesterase activity in pregnancy (Schnider, 1965;Robertson, 1966)
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