Effects of gold sodium thiomalate on interferon stimulation of C2 synthesis and HLA–DR expression by human monocytes

Abstract

Gamma-interferon ( y-IFN) is a T cell-derived lymphokine that has potent macrophage-activating properties. It increases Fc receptor density, increases the formation and release of reactive oxygen intermediates, increases the synthesis and release of complement cascade proteins, especially C2 and factor B, and increases class I1 (HLA-DR) antigen expression. These effects may play a role in the potentiation of inflammation in rheumatoid arthritis. We examined the possibility that gold sodium thiomalate (GST), an effective treatment for rheumatoid arthritis, would inhibit y-IFN-mediated stimulation of monocyte/macrophages. GST in concentrations attainable in vivo was shown to inhibit both spontaneous and yIFN-stimulated C2 production up to 50%. GST inhibition could be only partially overcome with increasing concentrations of y-IFN. In addition, GST inhibited y-IFN-stimulated Thomas Fund publication no. 242.

Recent Advances of Gold Compounds in Anticancer Immunity

“…Type I ICD inducers exert multiple cytotoxic effects and trigger ER stress as a secondary mode of action, while type II inducers mediates ROS-related ER-stress as the main mechanism of action (Garg et al, 2015). By far most of the ICD inducers used in clinical anticancer chemotherapy belong to type I class, such as anthracyclines and mitoxantrone, the glycopeptide Measel, 1975;Havarinasab et al, 2007 Stimulates T effector and T suppressor lymphocytes C57BI mice Walz and Griswold, 1978 Low dose promotes MHC II, but high dose inhibits MHC II human monocytes Sanders et al, 1987 Aurothiopropanolsulfonate Enhances the antigen-specific IgE immune response Brown-Norway (BN) rats Kermarrec et al, 1996 HAuCl 4 Activates CD4+T and CD8+T cell, and promotes release of IFN-γ BN rats Savignac et al, 2001 Gold nanoparticles Promotes the immunogenicity of antigens, DC maturation, TLR9 expression, memory CD8+T cells activation, MHC II and CD 86 expression…”

Inhibitory effects of anti-rheumatic drugs on vascular endothelial growth factor in cultured rheumatoid synovial cells

“…Several disease-modifying anti-rheumatic drugs (DMARDs) have been used to control RA. While the majority of these DMARDs act as immunomodulatory drugs in RA [18][19][20][21][22][23][24][25], some also act by inhibiting the angiogenic process [26][27][28][29][30][31]. However, the mechanism of the inhibitory effects of DMARDs on angiogenesis remains obscure.…”

Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen‐induced arthritis

“…Several disease‐modifying antirheumatic drugs (DMARDs) have been used to control the progression of RA. While the majority of these DMARDs act as immunomodulatory drugs in RA (25–32), some also act by inhibiting cytokines and endothelial cell proliferation (33–38). However, the mechanism underlying the inhibitory effects of DMARDs on ROS remains obscure.…”