Effects of Gold Nanoparticles on Erythrocyte Hemolysis

Aseichev, A. V.; Азизова, О. А.; Beckman, E. M.; Skotnikova, O. I.; Dudnik, L. B.; Щегловитова, О. Н.; Сергиенко, В. И.

doi:10.1007/s10517-014-2383-6

Cited by 30 publications

(17 citation statements)

References 12 publications

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“…63 Gold NPs demonstrated hemolysis only at small sizes (< 30 nm), in a dose-dependent manner. 64,65 Similar response to silver NPs was also observed. 66,67 Naked chitosan NPs induce significant hemolysis, whereas no appreciable hemolysis is observed upon treatment of the NPs with NaOH.…”

Section: Hemolysis and Hemagglutinationsupporting

confidence: 65%

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Saha

Zhen

Erogbogbo

et al. 2019

Semin Thromb Hemost

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Nanoparticles have numerous biomedical applications including, but not limited to, targeted drug delivery, diagnostic imaging, sensors, and implants for a wide range of diseases including cancer, diabetes, heart disease, and tuberculosis. Although the mode of delivery of the nanoparticles depends on the application and the disease, the nanoparticles are often in immediate contact with the systemic circulation either because of intravenous administration or their ability to enter the bloodstream with relative ease or their longer survival time in circulation. Once in circulation, the nanoparticles may elicit unintended hemostatic and inflammatory responses, and hence the design of nanoparticles for therapeutic applications should take broad hemocompatibility concerns into consideration. In this review, we present the principles underlying the structural and functional design of various classes of nanoparticles that are currently approved by the US Food and Drug Administration, categorize these particles based on their interactions with cardiovascular tissues and ensuing adverse events, and also describe various in vitro assays that may be used evaluate their hemocompatibility.

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Section: Hemolysis and Hemagglutinationsupporting

confidence: 65%

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Saha

Zhen

Erogbogbo

et al. 2019

Semin Thromb Hemost

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“…[39][40][41] Lastly, if the coating had chemically reacted with the red blood cells, some level of degradation should have taken place. This is also true for nanoparticles, which have only been shown to be capable of inducing hemolysis, rather than strengthen red blood cells against damage.…”

Section: Hemolysismentioning

confidence: 99%

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

et al. 2016

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The use of an external mechanical pump to sustain the circulation in a body, also known as extracorporeal circulation, is an integral part of many medical procedures such as hemodialysis and cardio-pulmonary bypass. However, the damage to red blood cells caused by the flow-induced shear stresses in the flow circuit has remained an intractable problem for many years, limiting the operational duration of extracorporeal circulation. In this study, near-superhydrophobic surfaces were investigated as a potential solution to mitigate the hemolysis of blood during extracorporeal pumping through the use of a proofof-concept flow circuit. It was found that the thin layer of air trapped by the near-superhydrophobic surface due to the Cassie-Baxter state reduced the wall shear stress exerted on the blood flow, resulting in a corresponding decrease in the rate of hemolysis. For blood that undergoes an oscillatory flow, this reduction in the hemolysis was shown to be directly related to the mean shear rate and shear rate amplitude of the flow.

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“…Ex vivo experiments on whole blood were conducted because erythrocytes together with other blood cells and serum content reflect properly the actual conditions in mammals. 40 Experiments were performed at t = 0, 2, 5, and 24 h in the dark and under LED irradiation, with the bactericidal concentration of amoxi@AuNP (1.5 μg/mL). Total hemolysis was established by adding H 2 O to the red blood cell samples; n = 3; SD < 0.1 (see Figure S7 for illumination details).…”

Section: Resultsmentioning

confidence: 99%

Selective Photoinduced Antibacterial Activity of Amoxicillin-Coated Gold Nanoparticles: From One-Step Synthesis to in Vivo Cytocompatibility

Rocca²,

Villarmois³

et al. 2018

ACS Omega

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Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 μg/mL) when co-cultures are analyzed. Their stability in biological media, hemocompatibility, and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.

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Effects of Gold Nanoparticles on Erythrocyte Hemolysis

Cited by 30 publications

References 12 publications

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

Selective Photoinduced Antibacterial Activity of Amoxicillin-Coated Gold Nanoparticles: From One-Step Synthesis to in Vivo Cytocompatibility

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