Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism

Guo, Ling; Cui, Ying; Hao, Kaijun

doi:10.1080/13880209.2018.1428634

Cited by 17 publications

(20 citation statements)

References 29 publications

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“…There are several studies investigated the effect of GL on the pharmacokinetics of other drugs got similar results. GL decreased the system exposure of asiatic acid by inducing the activity of CYP450 enzymes (Guo et al 2018), and GL increased the clearance rate of paeoniflorin via inducing the activity of CYP3A4 (Sun et al 2019). The co-administration of GL and celastrol could decrease the plasma concentration of celastrol, due to the enhancement GL exerted on the activity of CYP3A4 (Yan et al 2017).…”

Section: Discussionmentioning

confidence: 97%

“…Next, NBL was orally administered to rats by gavage at a dose of 50 mg/kg. The dosages used in the experiments were based on previous studies (Manthey et al 2011;Guo et al 2018;Sun et al 2019). Blood samples (250 lL) were collected into heparinised tubes via the oculi chorioideae vein at 0.083, 0.33, 0.5, 1, 2, 4, 6, 8, 10, 12 and 24 h after the oral administration of NBL.…”

Section: In Vivo Pharmacokinetic Studymentioning

confidence: 99%

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Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism

Wang

Dong

et al. 2020

Pharmaceutical Biology

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Context: Both nobiletin (NBL) and glycyrrhizin (GL) have anti-inflammatory and antitumor properties. These agents may be co-administered in the clinic. However, the drug-drug interaction between them is not clear. Objective: The drug-drug interaction between GL and NBL was investigated, to clarify the effect of GL on the pharmacokinetics of NBL, and its main mechanism. Materials and methods: The pharmacokinetic profiles of oral administration of NBL (50 mg/kg) in Sprague-Dawley rats of two groups with six each, with or without pre-treatment of GL (100 mg/kg/day for 7 days), were investigated. The effects of GL on the metabolic stability and transport of NBL were also investigated through the rat liver microsome and Caco-2 cell transwell models. Results: The results showed that GL significantly decreased the peak plasma concentration (from 1.74 ± 0.15 to 1.12 ± 0.10 lg/mL) and the t 1/2 (7.44 ± 0.65 vs. 5.92 ± 0.68) of NBL, and the intrinsic clearance rate of NBL was increased by the pre-treatment with GL (39.49 ± 2.5 vs. 48.29 ± 3.4 lL/min/mg protein). The Caco-2 cell transwell experiments indicated that GL could increase the efflux ratio of NBL from 1.61 to 2.41. Discussion and conclusion: These results indicated that GL could change the pharmacokinetic profile of NBL, via increasing the metabolism and efflux of NBL in rats. It also suggested that the dose of NBL should be adjusted when co-administrated with GL in the clinic.

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Section: Discussionmentioning

confidence: 97%

Section: In Vivo Pharmacokinetic Studymentioning

confidence: 99%

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism

Wang

Dong

et al. 2020

Pharmaceutical Biology

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“…Previously, inhibition or induction of cytochrome P450 enzymes (CYP450) was reported to be the main cause responsible for the drug-drug interaction. Especially, the activity of CYP3A4, an enzyme in the liver involved in the metabolism of various drugs, plays vital roles during the pharmacokinetics of several drugs, such as puerarin, warfarin, and asiatic acid, where the inhibition on CYP3A4 resulted in the drug-drug interaction (Guo et al 2018;Liu et al 2019;Song et al 2020). It has been reported that amlodipine is the substrate of CYP3A4, and curcumin has been demonstrated to be an inhibitor of CYP3A4 (Lee et al 2011;Zhu et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism

Jiang

Zhang

Xiang-zhi

et al. 2020

Pharmaceutical Biology

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Context: Hyperlipidaemia and hypertension are often treated together with curcumin and amlodipine. It is necessary to investigate the drug-drug interaction between curcumin and amlodipine. Objective: The interaction between curcumin and amlodipine was investigated in rats and with rat liver microsomes. Methods: The pharmacokinetics of amlodipine (1 mg/kg) was investigated in rats with or without curcumin pre-treatment (2 mg/kg), six rats in each group. The metabolic stability of amlodipine was investigated with rat liver microsomes. Results: Curcumin significantly increased the C max (26.19 ± 2.21 versus 17.80 ± 1.56 lg/L), AUC (0-t) (507.27 ± 60.23 versus 238.68 ± 45.59 lgÁh/L), and t 1/2 (14.69 ± 1.64 versus 11.43 ± 1.20 h) of amlodipine (p < 0.05). The metabolic stability of amlodipine was significantly increased with the half-life time in rat liver microsomes increased from 34.23 ± 3.33 to 44.15 ± 4.12 min, and the intrinsic rate decreased from 40.49 ± 3.26 to 31.39 ± 2.78 lL/min/mg protein. Discussion and conclusions: These results indicated that drug-drug interaction might appear during the co-administration of curcumin and amlodipine. The potential mechanism may be due to the inhibition of CYP3A4 by curcumin. Thus, this interaction should be given special attention in the clinic and needs further experiments to characterize the effect in humans.

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“…The activity of CYP450 was mainly related to the metabolic ability of the liver . Several studies showed that glycyrrhizin could regulate the activities of CYP1A2, CYP2D6, CYP2E1, and CYP3A4 . The mRNA expression of CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1 were analyzed by real‐time PCR after HepG2 cells incubated in the hydrogels for 3 days.…”

Section: X‐ray Diffractionmentioning

confidence: 99%

“…40 Several studies showed that glycyrrhizin could regulate the activities of CYP1A2, CYP2D6, CYP2E1, and CYP3A4. [41][42][43] The mRNA expression of CYP1A1, CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP2E1 were analyzed by real-time PCR after HepG2 cells incubated in the hydrogels for 3 days. The mRNA expressions of CYP enzymes in each group were showed in Figure 7.…”

Section: Cell Viabilitymentioning

confidence: 99%

Injectable hydrogels based on glycyrrhizin, alginate, and calcium for three‐dimensional cell culture in liver tissue engineering

Xiao-fang

Zhao

Ren

et al. 2018

J Biomedical Materials Res

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Injectable hydrogels have been paid more attentions on cell therapy and tissue regeneration resulting from the applications in minimally invasive surgical procedures with ease of handling and complete filling of defect area. Here, a biodegradable and injectable in situ hydrogel formed by glycyrrhizin (GL), alginate (Alg), and calcium (Ca) was developed for three‐dimensional (3D) cell culture. Differential scanning calorimetry (DSC), X‐ray diffraction (XRD), scanning electron microscope (SEM) and rheology analysis were performed to characterize GL‐Alg‐Ca hydrogel and evaluate its formation mechanism, properties, and morphology. The biocompatibility of hydrogel was investigated by cell viability, morphology, and liver specific functions. The results of DSC, XRD, and rheology suggested that hydrogel was homogenous complex with stable structure and well viscoelasticity. Human hepatoma HepG2 cells cultured in hydrogels showed well morphology. Compared with the control group, cells in hydrogels showed good biocompatibility, and could maintain the viability, proliferation and liver function for longer periods of time. Furthermore, the hydrogel improved the mRNA expression of cytochrome P450, which were key enzyme to the metabolization of hepatocytes. The GL‐Alg‐Ca hydrogel could be a potential 3D cells culture system for liver tissue engineering. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3292–3302, 2018.

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Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism

Cited by 17 publications

References 29 publications

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism

Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism

Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism

Injectable hydrogels based on glycyrrhizin, alginate, and calcium for three‐dimensional cell culture in liver tissue engineering

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