Effects of glycerol monostearate and Tween 80 on the physical properties and stability of recombined low-fat dairy cream

Wu, Shuke; Wang, Geng; Zhang, Lu; Li, Yan; Zhou, Xilong; Chen, Lintianxiang; Cao, Jialu; Zhang, Liebing

doi:10.1007/s13594-015-0274-x

Cited by 24 publications

(4 citation statements)

References 25 publications

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“…This increase is brought on by the oleic acid molecules’ free carboxylic groups, which have negative charges [ 39 ]. The amphiphilic nature of these glycerides, which tend to be adsorbed onto the LCN surfaces, displaying a shielding effect, was also linked to the decreased ZP values of Captex 8000 and Capmul MCM [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

et al. 2023

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To date, the ophthalmic application of liquid crystalline nanostructures (LCNs) has not been thoroughly reconnoitered, yet they have been extensively used. LCNs are primarily made up of glyceryl monooleate (GMO) or phytantriol as a lipid, a stabilizing agent, and a penetration enhancer (PE). For optimization, the D-optimal design was exploited. A characterization using TEM and XRPD was conducted. Optimized LCNs were loaded with the anti-glaucoma drug Travoprost (TRAVO). Ex vivo permeation across the cornea, in vivo pharmacokinetics, and pharmacodynamic studies were performed along with ocular tolerability examinations. Optimized LCNs are constituted of GMO, Tween® 80 as a stabilizer, and either oleic acid or Captex® 8000 as PE at 25 mg each. TRAVO-LNCs, F-1-L and F-3-L, showed particle sizes of 216.20 ± 6.12 and 129.40 ± 11.73 nm, with EE% of 85.30 ± 4.29 and 82.54 ± 7.65%, respectively, revealing the highest drug permeation parameters. The bioavailability of both attained 106.1% and 322.82%, respectively, relative to the market product TRAVATAN®. They exhibited respective intraocular pressure reductions lasting for 48 and 72 h, compared to 36 h for TRAVATAN®. All LCNs exhibited no evidence of ocular injury in comparison to the control eye. The findings revealed the competence of TRAVO-tailored LCNs in glaucoma treatment and suggested the potential application of a novel platform in ocular delivery.

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Section: Resultsmentioning

confidence: 99%

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

et al. 2023

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“…Hence, it can be assumed that glycerin can provide better stability and improve the physical properties of OEO-NCs. It has been reported that the emulsion stability and wettability of the particles are strongly dependent on the pH [ 31 ] and that increasing the pH of the emulsion causes higher absolute values of the Z-Pot, resulting in higher stability.…”

Section: Resultsmentioning

confidence: 99%

Formation and Characterization of Oregano Essential Oil Nanocapsules Applied onto Polyester Textile

Salinas

Arias²,

Coderch

et al. 2022

Polymers

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Oregano essential oil was encapsulated in poly-ϵ-caprolactone nanoparticles by a nanoprecipitation method using glycerin as a moisturizer. Nanocapsule characterization was performed by measuring the particle size, colloidal stability and encapsulation efficiency using dynamic light scattering, UV–Vis spectrophotometry and scanning electron microscopy (SEM). The nanoparticles had a mean particle size of 235 nm with a monomodal distribution. In addition, a low polydispersity index was obtained, as well as a negative zeta potential of −36.3 mV and an encapsulation efficiency of 75.54%. Nanocapsules were applied to polyester textiles through bath exhaustion and foulard processing. Citric acid and a resin were applied as crosslinking agents to improve the nanocapsules’ adhesion to the fabric. The adsorption, desorption, moisture content and essential oil extraction were evaluated to determine the affinity between the nanocapsules and the polyester. The adsorption was higher when the citric acid and the resin were applied. When standard oregano nanocapsules were used, almost all of the impregnated nanoparticles were removed when washed with water. The moisture content was evaluated for treated and non-treated textiles. There was a significant increase in the moisture content of the treated polyester compared to the non-treated polyester, which indicates that the polyester hydrophilicity increased with an important absorption of the essential oil nanocapsules; this can improve fabric comfort and probably promote antibacterial properties.

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“…However, it is important to notice that this rule applies only to an electrostatically stabilized system (27) . A reduction in ZP value was observed when the oleic acid ratio was increased above (10% w/w) which is associated with increased in particle size leading to reduction in surface charge density on the formed nanoparticles (28) .…”

Section: Particle Size and Zeta Potential Analysismentioning

confidence: 97%

Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

Abed

Hussein²

2019

IJPS

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Abstract The purpose of our study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%. about 92% of drug was released in 24hr in a controlled manner, the ex-vivo intestinal permeation study using the non-everted sac model shows four folds increment in the permeation of DE-NLCs compared to dabigatran etexilate suspension (DE-S).

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Effects of glycerol monostearate and Tween 80 on the physical properties and stability of recombined low-fat dairy cream

Cited by 24 publications

References 25 publications

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy

Formation and Characterization of Oregano Essential Oil Nanocapsules Applied onto Polyester Textile

Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

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