Effects of glycerol monolaurate on growth and physiology of chicks consuming diet containing fumonisin

Fortuoso, Bruno F.; Galli, Gabriela M.; Griss, Luiz Gustavo; Armanini, Eduardo H.; Silva, Aniélen D.; Fracasso, Mateus; Mostardeiro, Vitor Bastianello; Morsch, Vera Maria; Lopes, Leonardo Quintana Soares; Santos, Roberto C.V.; Gris, Anderson; Mendes, Ricardo E.; Boiago, Marcel M.; Silva, Aleksandro S. Da

doi:10.1016/j.micpath.2020.104261

Cited by 11 publications

(12 citation statements)

References 26 publications

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“…However, the body weight of chicks was not improved indicating that GML does not reduce the oxidative stress caused by fumonisins to a minimum. However, it alleviates oxidative stress caused by fumonisins and enhances the activity of glutathione S-transferase which is the enzyme responsible for liver detoxification [ 81 ].…”

Section: Detoxification Of Fumonisins Using Biological Antioxidantsmentioning

confidence: 99%

Toxic Mechanism and Biological Detoxification of Fumonisins

Wang

et al. 2022

Toxins

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Food safety is related to the national economy and people’s livelihood. Fumonisins are widely found in animal feed, feed raw materials, and human food. This can not only cause economic losses in animal husbandry but can also have carcinogenicity or teratogenicity and can be left in animal meat, eggs, and milk which may enter the human body and pose a serious threat to human health. Although there are many strategies to prevent fumonisins from entering the food chain, the traditional physical and chemical methods of mycotoxin removal have some disadvantages, such as an unstable effect, large nutrient loss, impact on the palatability of feed, and difficulty in mass production. As a safe, efficient, and environmentally friendly detoxification technology, biological detoxification attracts more and more attention from researchers and is gradually becoming an accepted technique. This work summarizes the toxic mechanism of fumonisins and highlights the advances of fumonisins in the detoxification of biological antioxidants, antagonistic microorganisms, and degradation mechanisms. Finally, the future challenges and focus of the biological control and degradation of fumonisins are discussed.

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Section: Detoxification Of Fumonisins Using Biological Antioxidantsmentioning

confidence: 99%

Toxic Mechanism and Biological Detoxification of Fumonisins

Wang

et al. 2022

Toxins

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“…Moreover, GML can inhibit mucosal signaling and the innate and inflammatory response to human immunodeficiency virus 1, which indicated the immunoregulatory effect of GML ( 8 ). Recent studies revealed that GML is an efficacious antibiotic growth promoter alternative for animal health and has the potential to become a unique fungicide owing to its established safety, antibacterial properties, and immunomodulatory capacity ( 9 , 10 ). The immune status and intestinal histomorphology of broilers can be enhanced by GML with a supplementary dosage of up to 5 g/kg to basal diets ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

et al. 2021

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This study was conducted to investigate the impact of glycerol monolaurate (GML) on performance, immunity, intestinal barrier, and cecal microbiota in broiler chicks. A total of 360 one-day-old broilers (Arbor Acres) with an average weight of 45.7 g were randomly allocated to five dietary groups as follows: basal diet and basal diets complemented with 300, 600, 900, or 1200 mg/kg GML. Samples were collected at 7 and 14 days of age. Results revealed that feed intake increased (P < 0.05) after 900 and 1200 mg/kg GML were administered during the entire 14-day experiment period. Dietary GML decreased (P < 0.05) crypt depth and increased the villus height-to-crypt depth ratio of the jejunum. In the serum and jejunum, supplementation with more than 600 mg/kg GML reduced (P < 0.05) interleukin-1β, tumor necrosis factor-α, and malondialdehyde levels and increased (P < 0.05) the levels of immunoglobulin G, jejunal mucin 2, total antioxidant capacity, and total superoxide dismutase. GML down-regulate (P < 0.05) jejunal interleukin-1β and interferon-γ expression and increased (P < 0.05) the mRNA level of zonula occludens 1 and occludin. A reduced (P < 0.05) expression of toll-like receptor 4 and nuclear factor kappa-B was shown in GML-treated groups. In addition, GML modulated the composition of the cecal microbiota of the broilers, improved (P < 0.05) microbial diversity, and increased (P < 0.05) the abundance of butyrate-producing bacteria. Spearman’s correlation analysis revealed that the genera Barnesiella, Coprobacter, Lachnospiraceae, Faecalibacterium, Bacteroides, Odoriacter, and Parabacteroides were related to inflammation and intestinal integrity. In conclusion, GML ameliorated intestinal morphology and barrier function in broiler chicks probably by regulating intestinal immune and antioxidant balance, as well as intestinal microbiota.

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“…According to Fortuoso et al (2020), one of the characteristics of GML is that it gives cells the ability to counteract an excess of ROS, decreasing free radicals over time in the group that received the blend. According to Valentini et al (2020), chicken meat enriched with polyunsaturated fatty acids contains more fatty acids with a high number of double bonds, possibly affecting oxidative stability and increasing its susceptibility to oxidation.…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, the lower lipid peroxidation in the intestines of chickens can be characterized initially by high non-enzymatic (thiols) and enzymatic (GST) high responses. Lipid peroxidation in cell membranes increases fluid loss due to increased ion permeability resulting in cell disruption, which leads to decreased antioxidant status and decreased degradation of free radicals, which are toxic to cells and tissues (Fortuoso et al 2020). In the current study, the addition of the blend based on lysolecithin, α-monolaurin, and butyric acids minimized oxidative reactions in the intestine, liver, and muscle at 42 days of age; except for the ROS levels that were higher in the jejunum on day 21, which can be a positive effect, since free radicals play an essential role in combating and controlling microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Use of blend based on an emulsifier, monolaurin, and glycerides of butyric acid in the diet of broilers: impacts on intestinal health, performance, and meat

Almeida

Araujo

Strapazzon

et al. 2021

An. Acad. Bras. Ciênc.

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The objective of this study was to evaluate whether the addition of a blend based on α-monolaurin mono-, di-and triglycerides of butyric acid, and lysolecithin on the performance even on diets containing reduced inclusion of oil in the diet and without the use of growth-promoting antibiotics of broilers considering the effect on health, performance, and meat. Three treatments were defi ned: positive control (TP: with enramycin), negative control (TN: no enramycin), and blend (T-FRA: with monolaurin and glycerides of acid butyric minus 0.8% soybean oil). At 21 days, broilers treated with TP and T-FRA obtained the lower feed conversion ratio (FC); at 35 days, T-FRA broilers obtained lower FC than TN broilers. Cholesterol levels were higher in the blood of T-FRA broilers. On day 42, levels of ROS and TBARS were lower in the intestine, muscles, and liver of T-FRA broilers. Moreover, glutathione S-transferase and total non-enzymatic antioxidants were greater at the intestinal and muscular levels. The T-FRA broilers had a lower percentage of lipids in the meat. The MIC indicated that 111mg of the blend/ mL inhibited the growth of E. coli; however, the counts of total coliforms and E. coli in the feces and the broilers' litter did not differ between treatments. In conclusion, the addition of the blend T-FRA in broiler diets was able to improve the feed conversion and maintain the other performance parameters even considering a reduction of 0.8% in the inclusion of oil.

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Effects of glycerol monolaurate on growth and physiology of chicks consuming diet containing fumonisin

Cited by 11 publications

References 26 publications

Toxic Mechanism and Biological Detoxification of Fumonisins

Toxic Mechanism and Biological Detoxification of Fumonisins

Glycerol Monolaurate Ameliorated Intestinal Barrier and Immunity in Broilers by Regulating Intestinal Inflammation, Antioxidant Balance, and Intestinal Microbiota

Use of blend based on an emulsifier, monolaurin, and glycerides of butyric acid in the diet of broilers: impacts on intestinal health, performance, and meat

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