Effects of glycerol and urea on micellization, membrane partitioning and solubilization by a non-ionic surfactant

Patel, Hiren; Raval, Gaurav; Nazari, Mozhgan; Heerklotz, Heiko

doi:10.1016/j.bpc.2010.03.015

Cited by 35 publications

(43 citation statements)

References 55 publications

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“…To improve the performance and properties of the alkyl ethoxylate surfactant solutions, various additives such as alcohols [18][19][20] , inorganic salts 19,21 , and sugars 22 are commonly used as solution additives to the pure surfactant solution. Perhaps the most frequently used additives are aliphatic alcohols as they can act as cosurfactants.…”

Section: Introductionmentioning

confidence: 99%

Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study

Vierros

Sammalkorpi

2018

Phys. Chem. Chem. Phys.

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The micelles of the non-ionic CE surfactant and 1-hexanol as an aqueous solution additives are studied toward the purpose of understanding the role of alcohol additives in tuning the characteristics of alkyl-ethoxylate micellar systems. Our dynamic light scattering and cloud point experiments show that the addition of hexanol induces a response similar to an increase of temperature. We associate the change with increased attraction between the micelles at low to moderate hexanol loadings and a potential increase of the aggregate size at a high hexanol-to-surfactant ratio. Detailed molecular dynamic simulation characterization shows that hexanol solubilizes to a micelle palisade layer when the hexanol-to-CE ratio is less than or equal to 0.5 while swollen micelles, in which a part of hexanol forms an oil core, are present when the ratio increases above approximately 1.5. The simulations indicate that the surface of the micelles is rough. Formation of reverse hexanol structures akin to those found in bulk octanol is observed in the oil core. Molecular simulations associate the increase in attraction between micelles observed via the experiments with decreased chain density in the headgroup region. This density decrease is caused by hexanol molecules solubilized between neighbouring surfactants. Altogether, these findings provide detailed physical characterization of the effect of an archetypal solution additive, hexanol, on an alkyl ethoxylate micelle system. These findings could bear a significance in designing micellar and emulsion based systems with desired solution characteristics or properties for e.g. drug delivery, catalysis, or platforms for green chemistry reactions.

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Section: Introductionmentioning

confidence: 99%

Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study

Vierros

Sammalkorpi

2018

Phys. Chem. Chem. Phys.

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“…Given the increasing body of literature on protein-detergent interactions; on the complex effects of cosolvents such as urea on the intrinsic curvature, order, and packing of detergents and phospholipid bilayers (60); and on the impact of natural membrane components on stability, future studies of TMD stability should be informed and facilitated by a greater understanding of protein-solvent interactions.…”

Section: Discussionmentioning

confidence: 99%

Protein Structure in Membrane Domains

Rath

Deber

2012

Annu. Rev. Biophys.

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Of great interest to the academic and pharmaceutical research communities, helical transmembrane proteins are characterized by their ability to dissolve and fold in lipid bilayers-properties conferred by polypeptide spans termed transmembrane domains (TMDs). The apolar nature of TMDs necessitates the use of membrane-mimetic solvents for many structure and folding studies. This review examines the relationship between TMD structure and solvent environment, focusing on principles elucidated largely in membrane-mimetic environments with single-TMD protein and peptide models. Following a brief description of TMD sequence and conformational characteristics gleaned from the structural database, we present an overview of the conceptual models used to study folding in vitro. The impact of sequence and solvent context on the incorporation of TMDs into membranes, and its role in measurements of TMD self-assembly strengths, is then described. We conclude with a discussion of the nonspecific effects of membrane components on TMD stability. 135 Annu. Rev. Biophys. 2012.41:135-155. Downloaded from www.annualreviews.org by Indiana University -Purdue University Indianapolis -IUPUI on 10/01/12. For personal use only.

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“…For 1.0 mol�kg -1 urea, increases the cmc of AMT, 14-E2-14, and AMT+14-E2-14 mixed systems more as compared to 0.5 mol�kg -1 urea, hence the negative DG � mic value of AMT, 14-E2-14, and AMT+14-E2-14 mixed systems in the presence of 0.5 mol�kg -1 urea is higher. The addition of urea changes the bulk phase properties making it more favorable than the aqueous system for amphiphilic monomers [50], therefore, the movement of the hydrophobic chain from the bulk phase toward the micellar region is become less favorable, and hence the value of DG � mic becomes less negative. Furthermore, the obtained DG � mic value can be incorporated into the standard Gibbs energy of adsorption (DG � ad ) at the interfacial surface to evaluate their values for neat and mixed systems by means of the equation given below [51,52].…”

Section: Thermodynamic Parametersmentioning

confidence: 99%

Investigation of micellar and interfacial phenomenon of amitriptyline hydrochloride with cationic ester-bonded gemini surfactant mixture in different solvent media

Rub

2020

PLoS ONE

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Herein, the interaction among the antidepressant drug amitriptyline hydrochloride (AMT) and a green gemini surfactant, ethane-1, 2-diyl bis(N,N-dimethyl-N-tetradecylammoniumacetoxy) dichloride (14-E2-14), via numerous techniques such as tensiometry, fluorimetry, FT-IR and UV-visible spectroscopy in three different media (aqueous 0.050 mol·kg-1 NaCl, 0.50 and 1.0 mol·kg-1 urea) were investigated. AMT is used to treat mental illness or mood problems, such as depression. The aggregation of biologically active ingredients can enhance the bioavailability of hydrophobic drugs. A significant interaction between AMT and 14-E2-14 was detected by tensiometric study as the critical micelle concentration (cmc) of AMT+14-E2-14 is reduced upon an increase of mole fraction (α1) of 14-E2-14. The decrease in cmc indicates the nonideality of studied mixtures of different compositions. Although, employed drug AMT is freely soluble in the aqueous and non-aqueous system but is not hydrophobic enough to act as its carrier. Instead, gemini surfactant formed spherical micelles in an aqueous system and their high solubilization capability, as well as their relatively lower cmc value, makes them highly stable in vivo. The cmc values of AMT+14-E-14 mixtures in all cases were further decreased and increased in NaCl and urea solutions respectively as compared with the aqueous system. Numerous micellar, interfacial, and thermodynamic parameters have been measured by applying various theoretical models. The obtained changes in the physicochemical assets of AMT upon adding of 14-E2-14 are likely to enhance the industrial and pharmaceutical applications of gemini surfactants. The negative interaction parameters (βm and βσ), indicate synergistic attraction is occurring in the mixed systems. The aggregation number (Nagg), Stern–Volmer constant (Ksv), etc. are attained through the fluorescence method, also supporting the attractive interaction behavior of AMT+14-E2-14 mixtures in all solvents. The Nagg was found to increase in the salt solution and decrease in the urea system compared with the aqueous solution. FT-IR and UV-visible analysis also depict the interaction between the constituent alike tensiometry and fluorimetry methods. The results suggested that gemini surfactants may serve as a capable drug delivery agent for antidepressants, improving their bioavailability.

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Effects of glycerol and urea on micellization, membrane partitioning and solubilization by a non-ionic surfactant

Cited by 35 publications

References 55 publications

Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study

Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study

Protein Structure in Membrane Domains

Investigation of micellar and interfacial phenomenon of amitriptyline hydrochloride with cationic ester-bonded gemini surfactant mixture in different solvent media

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Effects of glycerol and urea on micellization, membrane partitioning and solubilization by a non-ionic surfactant

Cited by 35 publications

References 55 publications

Effects of 1-hexanol on C12E10 micelles: a molecular simulations and light scattering study

Effects of 1-hexanol on C12E10 micelles: a molecular simulations and light scattering study

Protein Structure in Membrane Domains

Investigation of micellar and interfacial phenomenon of amitriptyline hydrochloride with cationic ester-bonded gemini surfactant mixture in different solvent media

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Product

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Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study

Effects of 1-hexanol on C₁₂E₁₀ micelles: a molecular simulations and light scattering study