Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis

Shan, Weifeng; Chen, Bingquan; Zhu, Shu; Jiang, Li; Zhou, Yanfeng

doi:10.1631/jzus.b1100001

Cited by 25 publications

(19 citation statements)

References 26 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, insulin resistance, that usually increase in patients with end stage liver disease [24], [25], favored the lipolysis and free fatty acids β-oxidation led to the formation of ketones [26]. This hypothesis is further supported by the direct correlation between the levels of C8-ketone, present in the breath, and serum levels of bilirubin, as well as with the Child –Pugh stage of cirrhosis.…”

Section: Discussionmentioning

confidence: 89%

Rapid “Breath-Print” of Liver Cirrhosis by Proton Transfer Reaction Time-of-Flight Mass Spectrometry. A Pilot Study.

et al. 2013

View full text Add to dashboard Cite

The aim of the present work was to test the potential of Proton Transfer Reaction Time-of-Flight Mass Spectrometry (PTR-ToF-MS) in the diagnosis of liver cirrhosis and the assessment of disease severity by direct analysis of exhaled breath. Twenty-six volunteers have been enrolled in this study: 12 patients (M/F 8/4, mean age 70.5 years, min-max 42–80 years) with liver cirrhosis of different etiologies and at different severity of disease and 14 healthy subjects (M/F 5/9, mean age 52.3 years, min-max 35–77 years). Real time breath analysis was performed on fasting subjects using a buffered end-tidal on-line sampler directly coupled to a PTR-ToF-MS. Twelve volatile organic compounds (VOCs) resulted significantly differently in cirrhotic patients (CP) compared to healthy controls (CTRL): four ketones (2-butanone, 2- or 3- pentanone, C8-ketone, C9-ketone), two terpenes (monoterpene, monoterpene related), four sulphur or nitrogen compounds (sulfoxide-compound, S-compound, NS-compound, N-compound) and two alcohols (heptadienol, methanol). Seven VOCs (2-butanone, C8-ketone, a monoterpene, 2,4-heptadienol and three compounds containing N, S or NS) resulted significantly differently in compensate cirrhotic patients (Child-Pugh A; CP-A) and decompensated cirrhotic subjects (Child-Pugh B+C; CP-B+C). ROC (Receiver Operating Characteristic) analysis was performed considering three contrast groups: CP vs CTRL, CP-A vs CTRL and CP-A vs CP-B+C. In these comparisons monoterpene and N-compound showed the best diagnostic performance.ConclusionsBreath analysis by PTR-ToF-MS was able to distinguish cirrhotic patients from healthy subjects and to discriminate those with well compensated liver disease from those at more advanced severity stage. A breath-print of liver cirrhosis was assessed for the first time.

show abstract

Section: Discussionmentioning

confidence: 89%

Rapid “Breath-Print” of Liver Cirrhosis by Proton Transfer Reaction Time-of-Flight Mass Spectrometry. A Pilot Study.

et al. 2013

View full text Add to dashboard Cite

show abstract

“…endogenous GAL in brain may accelerate GLUT4 vesicle exocytosis and slow its endocytosis to move more GLUT4 to plasma membranes. This results in a beneficial effect on insulin sensitivity, while malfunction of this process may lead to insulin resistance and diabetes mellitus (Shan et al, 2011). The inhibition of GLUT4 translocation is one of the most important causes of poor glucose transportation in the body.…”

Section: Discussionmentioning

confidence: 99%

Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

Zhang

Sheng

Guo

et al. 2012

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…It is preferentially expressed in skeletal muscle and adipose tissue [9]. Many studies have shown that the reduced expression of GLUT4 is associated with blood glucose accumulation, insulin resistance, and diabetes development [10,11]. Several studies have indicated that in addition to GLUT4, interleukin-6 (IL-6) has a critical role in DM as well.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercises on IL-6 and GLUT4 Expression in Diabetic Rats

Dehghan

Farzanegi

Abbaszadeh

2019

RMM

View full text Add to dashboard Cite

Background: Diabetes mellitus is one of the most common metabolic disorders worldwide. Empirical evidence has shown exercise to be of value in ameliorating symptoms of diabetes, but the underlying molecular mechanisms involved have not been well-studied. To evaluate the effects of continuous and interval exercises on blood glucose and insulin levels and on IL-6 and GLUT4 expression in diabetic rats. Materials and Methods: Old Wistar rats with streptozotocin-induced diabetes were randomly divided into three groups; namely, the patient (non-exercise control) group, the interval exercise group, and the continuous exercise group. The blood insulin level was measured using a specific ELISA kit, whereas the blood glucose level was determined with an AutoAnalyzer apparatus. Expression of the IL-6 and GLUT4 genes in skeletal muscle was determined using real-time PCR. All data were analyzed using SPSS software. Results: The expression of IL-6 and GLUT4 was significantly decreased in skeletal muscle of the diabetic rats (p < 0.001). Continuous (9.97-fold; p = 0.000) and interval (7.11-fold; p = 0.000) exercises significantly increased the expression of IL-6 relative to that in the animals of the patient group. Furthermore, continuous (9.36-fold; p = 0.000) and interval (7.65-fold; p = 0.001) exercises also significantly increased the expression of GLUT4 relative to that of the patient group. Both types of exercise training were associated with a significant decrease in the blood glucose and insulin levels compared with the levels in the patient group (p < 0.0001). Conclusions: Diabetes is significantly associated with IL-6 and GLUT4 downregulation, but this can be reversed through continuous and interval exercises, which also help to lower the blood glucose and insulin levels significantly.

show abstract

Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis

Cited by 25 publications

References 26 publications

Rapid “Breath-Print” of Liver Cirrhosis by Proton Transfer Reaction Time-of-Flight Mass Spectrometry. A Pilot Study.

Rapid “Breath-Print” of Liver Cirrhosis by Proton Transfer Reaction Time-of-Flight Mass Spectrometry. A Pilot Study.

Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

Effects of Exercises on IL-6 and GLUT4 Expression in Diabetic Rats

Contact Info

Product

Resources

About